Gene · 7804
LRP8: LDL receptor related protein 8
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. LRP8: LDL receptor related protein 8. Genes, record 7804. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7804
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14114 | Low-density lipoprotein receptor-related protein 8 | 963 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents43
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026062949 A | 2026-04-10 | 12 | Q14114 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 51927 | Q14114 | Espacenet |
| US 12502368 B2 | 2025-12-23 | 12 | Q14114 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4227 | Q14114 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 221 | Q14114 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2442 | Q14114 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2442 | Q14114 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4227 | Q14114 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 221 | Q14114 | Espacenet |
| JP 2024041827 A | 2024-03-27 | 12 | Q14114 | Espacenet |
1 to 10 of 43
See all 43 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,302
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | LRP8 papers | Newest fiscal year |
|---|---|---|---|
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 5 | 2025 |
| R01AI164653 | LDLRAD3 Receptor Interaction with Venezuelan Equine Encephalitis Virus | 5 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| R01HL124021 | An endothelial-fibroblast axis connecting senescence to amino acid metabolism for control of vascular stiffness in PAH | 4 | 2025 |
| T32AG000222 | Training in the Molecular Biology of Neurodegeneration and Alzheimer's Disease | 4 | 2025 |
| P20GM103466 | HAWAII INBRE V PROGRAM | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| P51OD011092 | Support for National Primate Research Center | 3 | 2025 |
1 to 10 of 1,302Source NIH's project files
See all 1,302 nih grantsPapers1,602
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells. | Proc Natl Acad Sci U S A | 2026 | 42814555 | PubTator, text mining | PubMed |
| Dual CHK1 and WNT Inhibition as a Synergistic Therapy for Gastrointestinal Neuroendocrine Carcinoma. | Cancer Res Commun | 2026 | 42811518 | PubTator, text mining | PubMed |
| Resident tissue macrophages transfer selenium transporter protein to protect pancreatic cancer from ferroptosis. | Cell | 2026 | 42785301 | PubTator, text mining | PubMed |
| Alternative splicing in Alzheimer's disease: event-level evidence, risk-locus biology, and RNA-based therapeutic perspectives. | Gene | 2026 | 42744164 | PubTator, text mining | PubMed |
| Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities. | Mol Cell Neurosci | 2026 | 42362005 | PubTator, text mining | PubMed |
| Targeting ACKR3/CXCR7 enhances platelet anticoagulant acylcarnitines and modulates procoagulant function. | Blood | 2026 | 42296019 | PubTator, text mining | PubMed |
| LRP4 is an entry receptor for multiple encephalitic alphaviruses. | Nat Commun | 2026 | 42265108 | PubTator, text mining | PubMed |
| Role of Hyperlipidemia-Related PCSK9, APOE, and LRP8 Variants in Restenosis after Stent Implantation in Male Patients: A Case-Control Study. | Mol Syndromol | 2026 | 42253317 | PubTator, text mining | PubMed |
| Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells. | bioRxiv | 2026 | 42239248 | PubTator, text mining | PubMed |
| Novel mechanisms linking platelet activation to antiphospholipid syndrome. | Curr Opin Immunol | 2026 | 42214306 | PubTator, text mining | PubMed |
1 to 10 of 1,602
See all 1,602 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7804
GET https://conductscience.org/api/genes/v1/7804/patents?page=2