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Gene · 7804

LRP8: LDL receptor related protein 8

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. LRP8: LDL receptor related protein 8. Genes, record 7804. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7804

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Gene

Symbol
LRP8
HGNC
Name
LDL receptor related protein 8
HGNC
NCBI Gene ID
7804
NCBI Gene
HGNC ID
HGNC:6700
HGNC
Ensembl
ENSG00000157193
NCBI Gene
Aliases
APOER2, HSZ75190, LRP-8, MCI1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14114Low-density lipoprotein receptor-related protein 89634Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062949 A2026-04-1012Q14114Espacenet
JP 2026004568 A2026-01-1451927Q14114Espacenet
US 12502368 B22025-12-2312Q14114Espacenet
EP 4650780 A22025-11-194227Q14114Espacenet
EP 4641202 A22025-10-29221Q14114Espacenet
JP 2025529142 A2025-09-042442Q14114Espacenet
US 12371689 B22025-07-292442Q14114Espacenet
JP 2025517970 A2025-06-124227Q14114Espacenet
KR 1020250017231 A2025-02-04221Q14114Espacenet
JP 2024041827 A2024-03-2712Q14114Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,302

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleLRP8 papersNewest fiscal year
P30DK058404Molecular and Cellular Basis for Digestive Diseases52025
R01AI164653LDLRAD3 Receptor Interaction with Venezuelan Equine Encephalitis Virus52025
P30CA021765Cancer Center Support Grant (CCSG)42025
R01HL124021An endothelial-fibroblast axis connecting senescence to amino acid metabolism for control of vascular stiffness in PAH42025
T32AG000222Training in the Molecular Biology of Neurodegeneration and Alzheimer's Disease42025
P20GM103466HAWAII INBRE V PROGRAM32025
P30CA016672Cancer Center Support Grant32025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202832025
P30CA068485Cancer Center Support Grant32025
P51OD011092Support for National Primate Research Center32025

1 to 10 of 1,302Source NIH's project files

See all 1,302 nih grants

Papers1,602

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells.Proc Natl Acad Sci U S A202642814555PubTator, text miningPubMed
Dual CHK1 and WNT Inhibition as a Synergistic Therapy for Gastrointestinal Neuroendocrine Carcinoma.Cancer Res Commun202642811518PubTator, text miningPubMed
Resident tissue macrophages transfer selenium transporter protein to protect pancreatic cancer from ferroptosis.Cell202642785301PubTator, text miningPubMed
Alternative splicing in Alzheimer's disease: event-level evidence, risk-locus biology, and RNA-based therapeutic perspectives.Gene202642744164PubTator, text miningPubMed
Apolipoprotein E in Alzheimer's disease: A review of APOE receptors, signalling pathways and therapeutic opportunities.Mol Cell Neurosci202642362005PubTator, text miningPubMed
Targeting ACKR3/CXCR7 enhances platelet anticoagulant acylcarnitines and modulates procoagulant function.Blood202642296019PubTator, text miningPubMed
LRP4 is an entry receptor for multiple encephalitic alphaviruses.Nat Commun202642265108PubTator, text miningPubMed
Role of Hyperlipidemia-Related PCSK9, APOE, and LRP8 Variants in Restenosis after Stent Implantation in Male Patients: A Case-Control Study.Mol Syndromol202642253317PubTator, text miningPubMed
Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells.bioRxiv202642239248PubTator, text miningPubMed
Novel mechanisms linking platelet activation to antiphospholipid syndrome.Curr Opin Immunol202642214306PubTator, text miningPubMed

1 to 10 of 1,602

See all 1,602 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7804

GET https://conductscience.org/api/genes/v1/7804/patents?page=2