Gene · 781
CACNA2D1: calcium voltage-gated channel auxiliary subunit alpha2delta 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CACNA2D1: calcium voltage-gated channel auxiliary subunit alpha2delta 1. Genes, record 781. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/781
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P54289 | Voltage-dependent calcium channel subunit alpha-2/delta-1 | 1,103 | 30 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 7268 | P54289 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7213 | P54289 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 1966 | P54289 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 697 | P54289 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5710 | P54289 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5710 | P54289 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 697 | P54289 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7213 | P54289 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7268 | P54289 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10628 | P54289 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs13
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ATAGABALIN | CHEMBL593430 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| BEPRIDIL | CHEMBL1008 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| BEPRIDIL HYDROCHLORIDE | CHEMBL1200382 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| GABAPENTIN | CHEMBL940 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| GABAPENTIN ENACARBIL | CHEMBL1628502 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| IMAGABALIN | CHEMBL2103836 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| MIROGABALIN | CHEMBL3545125 | Voltage-gated calcium channel alpha2/delta subunit 1 modulator | MODULATOR | ChEMBL |
| MIROGABALIN BESYLATE | CHEMBL3545257 | Voltage-gated calcium channel alpha2/delta subunit 1 modulator | MODULATOR | ChEMBL |
| PHLOROGLUCINOL | CHEMBL473159 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| PREGABALIN | CHEMBL1059 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
1 to 10 of 13
See all 13 drugsTrials385
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07606638 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07598474 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07429734 | GABAPENTIN | PHASE3 | ClinicalTrials.gov | |
| NCT07382921 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07344467 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07307170 | MIROGABALIN | ClinicalTrials.gov | ||
| NCT07230197 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07230171 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07208357 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07196657 | PREGABALIN | ClinicalTrials.gov |
1 to 10 of 385
See all 385 trialsNIH grants794
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CACNA2D1 papers | Newest fiscal year |
|---|---|---|---|
| R01NS101880 | Molecular Determinants of Synaptic Plasticity in Chronic Pain | 6 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 3 | 2025 |
| R01DA041711 | Signaling Mechanisms of Opioid-Induced Hyperalgesia and Tolerance | 3 | 2025 |
| R01NS132398 | Mechanisms of Epigenetic Plasticity in Neuropathic Pain | 3 | 2025 |
| P30AG066509 | University of Washington Alzheimer's Disease Research Center | 2 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 2 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 2 | 2025 |
| P30CA062203 | Cancer Center Support Grant | 2 | 2025 |
| R01NS094754 | The Role of Opponent Basal Ganglia Outputs in Behavior | 2 | 2025 |
| R35GM122528 | Dynamics Of Ligand Gated Ion Channels | 2 | 2025 |
1 to 10 of 794Source NIH's project files
See all 794 nih grantsPapers986
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Epstein-Barr virus-associated chromatin activation and enhancer engagement in T/NK-cell lymphoproliferative diseases. | Blood | 2026 | 42685000 | PubTator, text mining | PubMed |
| Splicing Factor SF3B2 Regulates Cardiomyocyte Calcium Handling Through Alternative Splicing of Cardiac Ion Channel Genes. | bioRxiv | 2026 | 42619934 | PubTator, text mining | PubMed |
| HIV-1 gp120 Induces Nociceptive Hypersensitivity via α2δ-1-Bound NMDA Receptors at Primary Afferent→Excitatory Neuron Synapses. | J Neurosci | 2026 | 42225412 | PubTator, text mining | PubMed |
| The Correlation Between Plasma CACNA2D1 Protein Concentration and the Severity of Coronary Heart Disease. | J Cardiovasc Dev Dis | 2026 | 42188100 | PubTator, text mining | PubMed |
| The Underlying Mechanism of Shanxian Granule in the Treatment of Glioma Based on Network Pharmacological and Bioinformatics Analysis. | Curr Top Med Chem | 2026 | 41832974 | PubTator, text mining | PubMed |
| Artificial intelligence-enabled multi-omics biomarkers for immune checkpoint blockade: mechanisms, predictive modeling, and clinical translation. | Front Immunol | 2026 | 41808840 | PubTator, text mining | PubMed |
| Artificial Intelligence-Enabled Multi-Omics for Predicting Immune Checkpoint Inhibitor Response and Resistance. | J Multidiscip Healthc | 2026 | 41777263 | PubTator, text mining | PubMed |
| When targeted gene testing falls short: Case report of a novel SLC4A3 F347S genetic variant associated with short QT syndrome. | HeartRhythm Case Rep | 2026 | 41732448 | PubTator, text mining | PubMed |
| The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteins. | bioRxiv | 2026 | 41648177 | PubTator, text mining | PubMed |
| Exploratory RNA Sequencing Reveals Systemic Metabolic Dysregulation in Alzheimer's Disease: Insights from a Diverse Latin American Cohort. | Mol Neurobiol | 2026 | 41588241 | PubTator, text mining | PubMed |
1 to 10 of 986
See all 986 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/781
GET https://conductscience.org/api/genes/v1/781/patents?page=2