ConductScience.org, home

Gene · 781

CACNA2D1: calcium voltage-gated channel auxiliary subunit alpha2delta 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. CACNA2D1: calcium voltage-gated channel auxiliary subunit alpha2delta 1. Genes, record 781. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/781

On this page

Gene

Symbol
CACNA2D1
HGNC
Name
calcium voltage-gated channel auxiliary subunit alpha2delta 1
HGNC
NCBI Gene ID
781
NCBI Gene
HGNC ID
HGNC:1399
HGNC
Ensembl
ENSG00000153956
NCBI Gene
Aliases
CACNA2, CACNL2A, CCHL2A, DEE110, LINC01112, MHS3, alpha2delta-1, lncRNA-N3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P54289Voltage-dependent calcium channel subunit alpha-2/delta-11,10330Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-197268P54289Espacenet
EP 4641201 A22025-10-297213P54289Espacenet
JP 2025147176 A2025-10-061966P54289Espacenet
JP 2025529142 A2025-09-04697P54289Espacenet
JP 2025529142 A2025-09-045710P54289Espacenet
US 12371689 B22025-07-295710P54289Espacenet
US 12371689 B22025-07-29697P54289Espacenet
JP 2025517969 A2025-06-127213P54289Espacenet
JP 2025517970 A2025-06-127268P54289Espacenet
JP 2025062604 A2025-04-1410628P54289Espacenet

1 to 10 of 26

See all 26 patents

Drugs13

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATAGABALINCHEMBL593430Voltage-gated calcium channel modulatorMODULATORChEMBL
BEPRIDILCHEMBL1008Voltage-gated calcium channel blockerBLOCKERChEMBL
BEPRIDIL HYDROCHLORIDECHEMBL1200382Voltage-gated calcium channel blockerBLOCKERChEMBL
GABAPENTINCHEMBL940Voltage-gated calcium channel modulatorMODULATORChEMBL
GABAPENTIN ENACARBILCHEMBL1628502Voltage-gated calcium channel modulatorMODULATORChEMBL
IMAGABALINCHEMBL2103836Voltage-gated calcium channel modulatorMODULATORChEMBL
MIROGABALINCHEMBL3545125Voltage-gated calcium channel alpha2/delta subunit 1 modulatorMODULATORChEMBL
MIROGABALIN BESYLATECHEMBL3545257Voltage-gated calcium channel alpha2/delta subunit 1 modulatorMODULATORChEMBL
PHLOROGLUCINOLCHEMBL473159Voltage-gated calcium channel blockerBLOCKERChEMBL
PREGABALINCHEMBL1059Voltage-gated calcium channel modulatorMODULATORChEMBL

1 to 10 of 13

See all 13 drugs

Trials385

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants794

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCACNA2D1 papersNewest fiscal year
R01NS101880Molecular Determinants of Synaptic Plasticity in Chronic Pain62025
P30DK063491Diabetes Research Center (DRC)32025
R01DA041711Signaling Mechanisms of Opioid-Induced Hyperalgesia and Tolerance32025
R01NS132398Mechanisms of Epigenetic Plasticity in Neuropathic Pain32025
P30AG066509University of Washington Alzheimer's Disease Research Center22025
P30CA013696Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
P30CA062203Cancer Center Support Grant22025
R01NS094754The Role of Opponent Basal Ganglia Outputs in Behavior22025
R35GM122528Dynamics Of Ligand Gated Ion Channels22025

1 to 10 of 794Source NIH's project files

See all 794 nih grants

Papers986

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Epstein-Barr virus-associated chromatin activation and enhancer engagement in T/NK-cell lymphoproliferative diseases.Blood202642685000PubTator, text miningPubMed
Splicing Factor SF3B2 Regulates Cardiomyocyte Calcium Handling Through Alternative Splicing of Cardiac Ion Channel Genes.bioRxiv202642619934PubTator, text miningPubMed
HIV-1 gp120 Induces Nociceptive Hypersensitivity via α2δ-1-Bound NMDA Receptors at Primary Afferent→Excitatory Neuron Synapses.J Neurosci202642225412PubTator, text miningPubMed
The Correlation Between Plasma CACNA2D1 Protein Concentration and the Severity of Coronary Heart Disease.J Cardiovasc Dev Dis202642188100PubTator, text miningPubMed
The Underlying Mechanism of Shanxian Granule in the Treatment of Glioma Based on Network Pharmacological and Bioinformatics Analysis.Curr Top Med Chem202641832974PubTator, text miningPubMed
Artificial intelligence-enabled multi-omics biomarkers for immune checkpoint blockade: mechanisms, predictive modeling, and clinical translation.Front Immunol202641808840PubTator, text miningPubMed
Artificial Intelligence-Enabled Multi-Omics for Predicting Immune Checkpoint Inhibitor Response and Resistance.J Multidiscip Healthc202641777263PubTator, text miningPubMed
When targeted gene testing falls short: Case report of a novel SLC4A3 F347S genetic variant associated with short QT syndrome.HeartRhythm Case Rep202641732448PubTator, text miningPubMed
The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteins.bioRxiv202641648177PubTator, text miningPubMed
Exploratory RNA Sequencing Reveals Systemic Metabolic Dysregulation in Alzheimer's Disease: Insights from a Diverse Latin American Cohort.Mol Neurobiol202641588241PubTator, text miningPubMed

1 to 10 of 986

See all 986 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/781

GET https://conductscience.org/api/genes/v1/781/patents?page=2