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Gene · 7846

TUBA1A: tubulin alpha 1a

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TUBA1A: tubulin alpha 1a. Genes, record 7846. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7846

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Gene

Symbol
TUBA1A
HGNC
Name
tubulin alpha 1a
HGNC
NCBI Gene ID
7846
NCBI Gene
HGNC ID
HGNC:20766
HGNC
Ensembl
ENSG00000167552
NCBI Gene
Aliases
B-ALPHA-1, CDCBM16, FLJ25113, LIS3, TUBA3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q71U36Tubulin alpha-1A chain45115Ensembl, GeneID, HGNC

Source UniProt

Patents66

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468520Q71U36Espacenet
JP 2026004568 A2026-01-1468521Q71U36Espacenet
EP 4650780 A22025-11-1916026Q71U36Espacenet
EP 4650780 A22025-11-194045Q71U36Espacenet
JP 2025517970 A2025-06-124045Q71U36Espacenet
JP 2025517970 A2025-06-1216026Q71U36Espacenet
US 11934929 B22024-03-192Q71U36Espacenet
JP 2023073278 A2023-05-251Q71U36Espacenet
US 11446398 B22022-09-2093538Q71U36Espacenet
US 11446398 B22022-09-2093539Q71U36Espacenet

1 to 10 of 66

See all 66 patents

Drugs90

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AGS-16C3FCHEMBL4594455Tubulin disrupting agentDISRUPTING AGENTChEMBL
ANETUMAB RAVTANSINECHEMBL2109629Tubulin inhibitorINHIBITORChEMBL
ANG1005CHEMBL1089636Tubulin inhibitorINHIBITORChEMBL
ANVATABART OPADOTINCHEMBL4297892Tubulin inhibitorINHIBITORChEMBL
APRUTUMAB IXADOTINCHEMBL4650293Tubulin inhibitorINHIBITORChEMBL
ASG-5MECHEMBL2109574Tubulin inhibitorINHIBITORChEMBL
AVE-9633CHEMBL2109266Tubulin inhibitorINHIBITORChEMBL
AZINTUXIZUMAB VEDOTINCHEMBL4297859Tubulin inhibitorINHIBITORChEMBL
BELANTAMAB MAFODOTINCHEMBL4298209Tubulin inhibitorINHIBITORChEMBL
BIIB-015CHEMBL2109575Tubulin inhibitorINHIBITORChEMBL

1 to 10 of 90

See all 90 drugs

Trials8,728

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604766PACLITAXELPHASE3ClinicalTrials.gov
NCT07602907PACLITAXELPHASE2ClinicalTrials.gov
NCT07601737PACLITAXELPHASE2ClinicalTrials.gov
NCT07601178PACLITAXELPHASE2ClinicalTrials.gov
NCT07599163PACLITAXELClinicalTrials.gov
NCT07595770PACLITAXELPHASE2ClinicalTrials.gov
NCT07594548PACLITAXELPHASE1ClinicalTrials.gov
NCT07591467DOCETAXELPHASE3ClinicalTrials.gov
NCT07589972VINORELBINEClinicalTrials.gov
NCT07588698VINCRISTINE SULFATEPHASE2ClinicalTrials.gov

1 to 10 of 8,728

See all 8,728 trials

NIH grants1,314

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTUBA1A papersNewest fiscal year
R01NS058721ACC: Callosal Agenesis as a Window into Common Neurodevelopmental Disorders112025
P30CA016672Cancer Center Support Grant42025
R01GM094231COMPUTATIONAL TOOLS FOR MASS SPECTROMETRY-BASED INTERACTOME DATA42025
T32GM136444Predoctoral Training in Molecular and Cellular Biology42025
P30CA036727Buffett Cancer Center Support Grant32025
P30CA054174Mays Cancer Center at UT Health SA32025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control32025
R35GM119569Deciphering Post-transcriptional Gene Regulatory Networks During Periods of Host-Pathogen Interaction and Innate Immune Activation32025
R37NS035129Human Epilepsy Genetics - Mosaic Mutations in Focal Epilepsy32025
P20GM103436IDeA Networks of Biomedical Research Excellence in Kentucky22025

1 to 10 of 1,314Source NIH's project files

See all 1,314 nih grants

Papers1,672

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Proteomics reveal serum biomarkers for early diagnosis in premature ovarian insufficiency.Front Endocrinol (Lausanne)202642824073PubTator, text miningPubMed
Diagnostic Yield of Sequencing in Prenatal Agenesis of the Corpus Callosum in a Well-Phenotyped International Cohort.Prenat Diagn202642791457PubTator, text miningPubMed
The effect and mechanism of TIPE in promoting M2 polarization through DcR3 in the microenvironment of colorectal cancer.Cancer Immunol Immunother202642776288PubTator, text miningPubMed
Gain-of-function suppressors restore microtubule dynamics and rescue dominant-negative tubulinopathies.Nat Cell Biol202642728306PubTator, text miningPubMed
Integrative single-cell and bulk transcriptomic profiling identify peripheral T-cell-associated candidate biomarkers in community-acquired pneumonia.Int J Med Sci202642694836PubTator, text miningPubMed
Developmental Profiles Associated with TUBA1A, TUBB2A, TUBB2B, and TUBB3 Tubulinopathy Conditions.Am J Intellect Dev Disabil202642593952PubTator, text miningPubMed
Genotypic and phenotypic heterogeneity in tubulinopathies: insights from a Turkish multicenter cohort.Neurol Sci202642472988PubTator, text miningPubMed
Alterations in the protein lactylation landscape of sperm from patients with varicocele-associated asthenozoospermia.Front Endocrinol (Lausanne)202642416903PubTator, text miningPubMed
Integrative Bioinformatic Characterization of the HDAC6-Driven Cytoskeleton-Wnt Signaling Interface in Hepatocellular Carcinoma: Implications for Immune Modulation and Therapeutic Targeting.Int J Mol Sci202642352927PubTator, text miningPubMed
Genetic causes of the lissencephaly spectrum: insights from chromosomal microarray and clinical/whole-exome sequencing.Croat Med J202642286901PubTator, text miningPubMed

1 to 10 of 1,672

See all 1,672 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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