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Gene · 7850

IL1R2: interleukin 1 receptor type 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IL1R2: interleukin 1 receptor type 2. Genes, record 7850. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7850

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Gene

Symbol
IL1R2
HGNC
Name
interleukin 1 receptor type 2
HGNC
NCBI Gene ID
7850
NCBI Gene
HGNC ID
HGNC:5994
HGNC
Ensembl
ENSG00000115590
NCBI Gene
Aliases
CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P27930Interleukin-1 receptor type 23981Ensembl, GeneID, HGNC

Source UniProt

Patents173

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11296P27930Espacenet
JP 2026004568 A2026-01-1450136P27930Espacenet
JP 2026004568 A2026-01-1450137P27930Espacenet
JP 2025172069 A2025-11-20206P27930Espacenet
JP 2025172069 A2025-11-20207P27930Espacenet
EP 4650780 A22025-11-195879P27930Espacenet
JP 2025147176 A2025-10-066966P27930Espacenet
JP 2025147176 A2025-10-066967P27930Espacenet
JP 2025147176 A2025-10-0616686P27930Espacenet
JP 2025529142 A2025-09-042084P27930Espacenet

1 to 10 of 173

See all 173 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,026

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIL1R2 papersNewest fiscal year
R01AI015614Pathogenesis of Fever in Man102025
P30CA008748Cancer Center Support Grant62025
P30ES010126UNC Center for Environmental Health and Susceptibility52025
P30EY010572Ophthalmology Core Facility52025
P01AI039671Costimulatory Mechanisms of Autoimmunity42025
P30AG028740University of Florida Older Americans Independence Center (OAIC)42025
P30CA086862Cancer Center Support Grant42025
R01HL076246Chemokines in healing myocardial infarction42025
R01HL085440Resolution of inflammation in healing myocardial infarcts42025
UL1TR001863Yale Clinical and Translational Science Award42025

1 to 10 of 2,026Source NIH's project files

See all 2,026 nih grants

Papers2,718

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
IL-1R2+ neutrophils define an early sterile injury-expanded subset that restrains inflammation and promotes repair.JCI Insight202642771477PubTator, text miningPubMed
Targeted proteomics reveal histiocytosis-associated neurodegeneration signatures.Hemasphere202642707979PubTator, text miningPubMed
A Decoy-Receptor-Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration.Adv Sci (Weinh)202642621674PubTator, text miningPubMed
Integrated Bioinformatics Analysis Identifies FCER1G, IL1R2, and BST1 as Diagnostic Biomarkers and Therapeutic Targets in Sepsis.J Clin Lab Anal202642590911PubTator, text miningPubMed
IL1R2⁺ Inflammatory Monocytes Contribute to Immune Dysregulation and Predict Mortality in COVID-19.Shock202642580331PubTator, text miningPubMed
Machine learning identifies neutrophil-related signatures for diagnostic value in neonatal sepsis.J Clin Biochem Nutr202642524644PubTator, text miningPubMed
Circulating immune profiling reveals impaired monocyte states and trajectories driving immunosuppression in glioblastoma.J Neuroinflammation202642464264PubTator, text miningPubMed
Systems-level insights into bronchopulmonary dysplasia from meta-analysis of genome-scale studies.Respir Res202642458458PubTator, text miningPubMed
IL1R2 identified as a key hub gene regulating vascular endothelial function in Kawasaki disease.Sci Rep202642373790PubTator, text miningPubMed
Blood transcriptomic endotyping of COPD identifies a neutrophil-driven inflammatory endotype reflected by the neutrophil-to-lymphocyte ratio.Respir Res202642351125PubTator, text miningPubMed

1 to 10 of 2,718

See all 2,718 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7850

GET https://conductscience.org/api/genes/v1/7850/patents?page=2