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CXCR4: C-X-C motif chemokine receptor 4

1 protein, 362 patents, 8 drugs, 160 trials, 19,061 NIH grants and 46,711 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCXCR4HGNC
NameC-X-C motif chemokine receptor 4HGNC
NCBI Gene ID7852NCBI Gene
HGNC IDHGNC:2561HGNC
EnsemblENSG00000121966NCBI Gene
AliasesCD184, D2S201E, FB22, HM89, HSY3RR, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS, WHIMS1, fusinNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P61073C-X-C chemokine receptor type 435233Ensembl, GeneID, HGNCUniProt

Patents 362

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026164123 A2026-08-061P61073Espacenet
JP 2026062654 A2026-04-1031P61073Espacenet
JP 2026504180 A2026-02-032P61073Espacenet
EP 4680730 A22026-01-2139P61073Espacenet
EP 4680730 A22026-01-219P61073Espacenet
JP 2025538131 A2025-11-2626P61073Espacenet
JP 2025536946 A2025-11-1235P61073Espacenet
JP 2025536946 A2025-11-1238P61073Espacenet
JP 2025536947 A2025-11-1250P61073Espacenet
JP 2025536947 A2025-11-1253P61073Espacenet

Drugs 8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BALIXAFORTIDECHEMBL4802129C-X-C chemokine receptor type 4 antagonistANTAGONISTChEMBL
BURIXAFORCHEMBL3545224C-X-C chemokine receptor type 4 antagonistANTAGONISTChEMBL
CTCE-9908CHEMBL3544949C-X-C chemokine receptor type 4 antagonistANTAGONISTChEMBL
MAVORIXAFORCHEMBL518924C-X-C chemokine receptor type 4 antagonistANTAGONISTChEMBL
MOTIXAFORTIDECHEMBL5095030C-X-C chemokine receptor type 4 antagonistANTAGONISTChEMBL
MSX-122CHEMBL3545330C-X-C chemokine receptor type 4 antagonistANTAGONISTChEMBL
PLERIXAFORCHEMBL18442C-X-C chemokine receptor type 4 partial agonistPARTIAL AGONISTChEMBL
ULOCUPLUMABCHEMBL3039543C-X-C chemokine receptor type 4 inhibitorINHIBITORChEMBL

Trials 160

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07585136PLERIXAFORPHASE1ClinicalTrials.gov
NCT07341022PLERIXAFORPHASE1/PHASE2ClinicalTrials.gov
NCT07188090PLERIXAFORPHASE2ClinicalTrials.gov
NCT06981806BALIXAFORTIDEPHASE1ClinicalTrials.gov
NCT06892119PLERIXAFORPHASE1ClinicalTrials.gov
NCT06547112MOTIXAFORTIDEPHASE1ClinicalTrials.gov
NCT06514508MOTIXAFORTIDEPHASE3ClinicalTrials.gov
NCT06506461PLERIXAFORPHASE1ClinicalTrials.gov
NCT06506461MOTIXAFORTIDEPHASE1ClinicalTrials.gov
NCT06442761MOTIXAFORTIDEPHASE1ClinicalTrials.gov

NIH grants 19061

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant2482,025NIH's project files
P30CA008748Cancer Center Support Grant1512,025NIH's project files
P30AI027763UCSF-Bay Area Center for AIDS Research672,025NIH's project files
ZIAAI000615Molecular Analysis Of Leukocyte Activation By Chemoattractants632,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award582,025NIH's project files
P30AI050410The University of North Carolina Center for AIDS Research572,025NIH's project files
P30CA006973Regional Oncology Research Center562,025NIH's project files
P30AI027767UAB Center for AIDS Research (CFAR)552,025NIH's project files
P30AI060354Harvard University Center for AIDS Research542,025NIH's project files
P30AI027757University of Washington/Fred Hutch Center for AIDS Research502,025NIH's project files

Papers 46711

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826626PubTator, text miningPubMed
42818140PubTator, text miningPubMed
42818012PubTator, text miningPubMed
42817075PubTator, text miningPubMed
42812889PubTator, text miningPubMed
42811017PubTator, text miningPubMed
42809427PubTator, text miningPubMed
42807596PubTator, text miningPubMed
42801211PubTator, text miningPubMed
42799298PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license