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Gene · 7855

FZD5: frizzled class receptor 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FZD5: frizzled class receptor 5. Genes, record 7855. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7855

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Gene

Symbol
FZD5
HGNC
Name
frizzled class receptor 5
HGNC
NCBI Gene ID
7855
NCBI Gene
HGNC ID
HGNC:4043
HGNC
Ensembl
ENSG00000163251
NCBI Gene
Aliases
C2orf31, DKFZP434E2135, HFZ5, MCOPCB11
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13467Frizzled-55854Ensembl, GeneID, HGNC

Source UniProt

Patents60

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026183201 A12026-09-035Q13467Espacenet
WO 2026183314 A12026-09-035Q13467Espacenet
JP 2026120541 A2026-07-2265Q13467Espacenet
JP 2026082857 A2026-05-1965Q13467Espacenet
EP 4650780 A22025-11-197901Q13467Espacenet
JP 2025529142 A2025-09-041642Q13467Espacenet
US 12371689 B22025-07-291642Q13467Espacenet
JP 2025517970 A2025-06-127901Q13467Espacenet
JP 2023532431 A2023-07-2882Q13467Espacenet
JP 2023517010 A2023-04-2180Q13467Espacenet

1 to 10 of 60

See all 60 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
VANTICTUMABCHEMBL2364652Frizzled-5 antagonistANTAGONIST

Source ChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02005315VANTICTUMABPHASE1ClinicalTrials.gov
NCT01973309VANTICTUMABPHASE1ClinicalTrials.gov
NCT01957007VANTICTUMABPHASE1ClinicalTrials.gov

NIH grants1,489

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFZD5 papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
P30CA008748Cancer Center Support Grant62025
P30CA023108Cancer Center Support Grant62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA016042Cancer Center Support Grant52025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P30DK034854Integrated Epithelial and Muscosal Biology52025
T32AI007526Emerging and Tropical Infectious Diseases52025
P30DK056338Texas Medical Center Digestive Diseases Center42025
R01NS080833Biology and Engineering of Botulinum Neurotoxins.42025

1 to 10 of 1,489Source NIH's project files

See all 1,489 nih grants

Papers1,967

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Propofol-Induced Metabolic, Apoptotic, and Wnt-Frizzled-Related Transcript Changes in MIA PaCa-2 Cells: In Vitro and Bioinformatic Analyses.Curr Issues Mol Biol202642793306PubTator, text miningPubMed
β-carotene alleviates PM2.5-induced pulmonary fibrosis via suppression of the Frizzled5-mediated Wnt5a/Ca2+pathway.Ecotoxicol Environ Saf202642759460PubTator, text miningPubMed
RNF research trends and an RNF43-based prognostic model for colorectal cancer with immune microenvironment analysis.Discov Oncol202642671492PubTator, text miningPubMed
FZD5 drives macrophage-mediated immunomodulation and predicts prognosis in glioma: evidence from single-cell sequencing.BMC Cancer202642410370PubTator, text miningPubMed
Controlling Tricyclic Peptide Architecture in mRNA Display through Orthogonal Reactivity on Rotationally Flexible Scaffolds.ACS Chem Biol202642205060PubTator, text miningPubMed
Integrative analysis identifies DCBLD2 and immune-related biomarkers for major depressive disorder: evidence from human peripheral blood, post-mortem brain, and rat models.Front Hum Neurosci202642148317PubTator, text miningPubMed
Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.J Biomed Mater Res B Appl Biomater202642032797PubTator, text miningPubMed
Antimicrobial peptide LL37 ameliorated experimental inflammation induced neonatal lung injury through macrophage immunomodulation.Pediatr Neonatol202641935947PubTator, text miningPubMed
Single-cell insights into trophoblast heterogeneity and adaptive dysfunction in selective fetal growth restriction.Commun Biol202641845016PubTator, text miningPubMed
Frizzled-9 Expression Is Associated With Aggressive Clinicopathological Features and Reduced Overall Survival in Invasive Breast Carcinoma.Pathol Int202641808318PubTator, text miningPubMed

1 to 10 of 1,967

See all 1,967 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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