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Gene · 79001

VKORC1: vitamin K epoxide reductase complex subunit 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. VKORC1: vitamin K epoxide reductase complex subunit 1. Genes, record 79001. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/79001

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Gene

Symbol
VKORC1
HGNC
Name
vitamin K epoxide reductase complex subunit 1
HGNC
NCBI Gene ID
79001
NCBI Gene
HGNC ID
HGNC:23663
HGNC
Ensembl
ENSG00000167397
NCBI Gene
Aliases
EDTP308, MST134, MST576, VKCFD2, VKOR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9BQB6Vitamin K epoxide reductase complex subunit 11636Ensembl, GeneID, HGNC

Source UniProt

Patents67

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469695Q9BQB6Espacenet
EP 4650780 A22025-11-1911219Q9BQB6Espacenet
JP 2025147176 A2025-10-0614076Q9BQB6Espacenet
JP 2025529142 A2025-09-045229Q9BQB6Espacenet
JP 2025529142 A2025-09-048030Q9BQB6Espacenet
US 12371689 B22025-07-295229Q9BQB6Espacenet
US 12371689 B22025-07-298030Q9BQB6Espacenet
JP 2025517970 A2025-06-1211219Q9BQB6Espacenet
JP 2025028160 A2025-02-2814076Q9BQB6Espacenet
KR 1020250010750 A2025-01-2114076Q9BQB6Espacenet

1 to 10 of 67

See all 67 patents

Drugs8

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACENOCOUMAROLCHEMBL397420Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitorINHIBITORChEMBL
DICUMAROLCHEMBL1466Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitorINHIBITORChEMBL
PHENINDIONECHEMBL711Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitorINHIBITORChEMBL
PHENPROCOUMONCHEMBL1465Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitorINHIBITORChEMBL
TECARFARINCHEMBL2105664Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitorINHIBITORChEMBL
WARFARINCHEMBL1464Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitorINHIBITORChEMBL
WARFARIN POTASSIUMCHEMBL1200772Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitorINHIBITORChEMBL
WARFARIN SODIUMCHEMBL1200879Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitorINHIBITORChEMBL

Trials134

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,643

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleVKORC1 papersNewest fiscal year
K24HL133373Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy182025
P30CA021765Cancer Center Support Grant (CCSG)172025
R01HL121718Structural and Functional Basis of the Vitamin K Cycle152025
T15LM007033Biomedical Informatics Training Program at Stanford132025
R01GM131008NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID MEMBRANES AND CELLS122025
T32GM007569Clinical Pharmacology Training Program112025
U01HG006379EHR-based Genomic Discovery and Implementation [Funded Extension]112025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment82025
U24HG010615PharmGKB62025
U54MD007600Center for Collaborative Research in Health Disparities62025

1 to 10 of 1,643Source NIH's project files

See all 1,643 nih grants

Papers3,438

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Limitations of VKORC1 rs9934438 as a Surrogate Marker for Vitamin K Antagonist Dose Adjustment.Basic Clin Pharmacol Toxicol202642823629PubTator, text miningPubMed
Machine Learning-Directed Explainable Artificial Intelligence and Bayesian Predictions of Warfarin Therapeutic Dose for Orthopedic Indications.Curr Pharm Des202642813643PubTator, text miningPubMed
Allelic Frequency of Single-Nucleotide Polymorphisms in CYP2C9, VKORC1, and CYP4F2 Genetic Variants in Patients With Mechanical Heart Valves on Acenocoumarol Drug Therapy.Cureus202642801138PubTator, text miningPubMed
Vietnamese pharmacogenomic variation in global context: a systematic review and meta-analysis for clinical implementation.Front Pharmacol202642756309PubTator, text miningPubMed
Clinically Relevant Pharmacogenomic Variant Frequencies in Kazakh, Russian, and Uzbek Population Groups Residing in Kazakhstan.Biology (Basel)202642737909PubTator, text miningPubMed
Prognostic value of genes associated with metastasis and propionate metabolism in rectal cancer.J Gastrointest Oncol202642703504PubTator, text miningPubMed
Cost-Effectiveness of Pharmacogenomics-Guided Treatment in Cardiovascular Disease: An Umbrella Review.Pharmgenomics Pers Med202642662837PubTator, text miningPubMed
γ-glutamyl carboxylase inhibition by Anisindione.Structure202642660115PubTator, text miningPubMed
Warfarin-Induced Developmental Toxicity: Insights into Embryogenesis, Teratogenicity, and Molecular Pathways.J Dev Biol202642647228PubTator, text miningPubMed
Pharmacogenomics in Dentistry: From CYP-Mediated Drug Response to Precision Prescribing in Oral Healthcare.Oral Dis202642630019PubTator, text miningPubMed

1 to 10 of 3,438

See all 3,438 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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