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FTO: FTO alpha-ketoglutarate dependent dioxygenase

1 protein, 49 patents, 1 drug, 3 trials, 4,636 NIH grants and 9,476 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFTOHGNC
NameFTO alpha-ketoglutarate dependent dioxygenaseHGNC
NCBI Gene ID79068NCBI Gene
HGNC IDHGNC:24678HGNC
EnsemblENSG00000140718NCBI Gene
AliasesALKBH9, BMIQ14, GDFD, IFEX9, KIAA1752, MGC5149NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9C0B1Alpha-ketoglutarate-dependent dioxygenase FTO50528Ensembl, GeneID, HGNCUniProt

Patents 49

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4802068 A12026-09-091Q9C0B1Espacenet
EP 4772646 A12026-07-081Q9C0B1Espacenet
US 12637684 B22026-05-261Q9C0B1Espacenet
EP 4687434 A22026-02-111Q9C0B1Espacenet
JP 2026004568 A2026-01-1445912Q9C0B1Espacenet
EP 4650780 A22025-11-1914252Q9C0B1Espacenet
EP 4640849 A22025-10-292575Q9C0B1Espacenet
EP 4641201 A22025-10-2916660Q9C0B1Espacenet
JP 2025519096 A2025-06-242575Q9C0B1Espacenet
JP 2025517969 A2025-06-1216660Q9C0B1Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BISANTRENECHEMBL25336Alpha-ketoglutarate-dependent dioxygenase FTO inhibitorINHIBITORChEMBL

Trials 3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05456269BISANTRENEPHASE1ClinicalTrials.gov
NCT04989335BISANTRENEPHASE2ClinicalTrials.gov
NCT03820908BISANTRENEPHASE2ClinicalTrials.gov

NIH grants 4636

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
RM1HG008935Center for dynamic RNA epitranscriptomes - Renewal472,025NIH's project files
P30DK063491Diabetes Research Center (DRC)462,025NIH's project files
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal352,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)302,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility302,025NIH's project files
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION272,025NIH's project files
ZIAHG000024Genetic analysis of type II diabetes262,025NIH's project files
R01DK075787Biological Insights from Genetic Investigation of ANthropometric Traits (GIANT) Across the Allelic Spectrum222,025NIH's project files
P30DK020541NYR-Diabetes Research Center (NYR-DRC)212,025NIH's project files
T32HL007055Cardiovascular Epidemiology Training Grant192,025NIH's project files

Papers 9476

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818985PubTator, text miningPubMed
42796933PubTator, text miningPubMed
42793095PubTator, text miningPubMed
42792700PubTator, text miningPubMed
42790767PubTator, text miningPubMed
42785232PubTator, text miningPubMed
42779519PubTator, text miningPubMed
42768086PubTator, text miningPubMed
42767182PubTator, text miningPubMed
42764990PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license