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Gene · 79132

DHX58: DExH-box helicase 58

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DHX58: DExH-box helicase 58. Genes, record 79132. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/79132

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Gene

Symbol
DHX58
HGNC
Name
DExH-box helicase 58
HGNC
NCBI Gene ID
79132
NCBI Gene
HGNC ID
HGNC:29517
HGNC
Ensembl
ENSG00000108771
NCBI Gene
Aliases
D11LGP2, D11lgp2e, LGP2, RLR-3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96C10ATP-dependent RNA helicase DHX586785Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443679Q96C10Espacenet
EP 4640849 A22025-10-29155Q96C10Espacenet
EP 4641201 A22025-10-29979Q96C10Espacenet
JP 2025138811 A2025-09-25100Q96C10Espacenet
JP 2025120300 A2025-08-15100Q96C10Espacenet
JP 2025519096 A2025-06-24155Q96C10Espacenet
JP 2025517969 A2025-06-12979Q96C10Espacenet
US 12123003 B22024-10-22100Q96C10Espacenet
US 11884978 B22024-01-30490Q96C10Espacenet
JP 2024501084 A2024-01-10245Q96C10Espacenet

1 to 10 of 39

See all 39 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,328

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDHX58 papersNewest fiscal year
P30DK034854Integrated Epithelial and Muscosal Biology182025
P01CA019014Viral Oncogenesis, Latency, and Replication112025
P51OD011132Emory National Primate Research Center112025
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged112025
P30CA016086Cancer Center Support Grant102025
P51OD010425Washington National Primate Research Center92025
U19AI089992Immune signatures of vaccine responses in vulnerable populations92025
R37AI087846Regulation of Host Innate Immunity Against Viral Infection72025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center62025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant62025

1 to 10 of 2,328Source NIH's project files

See all 2,328 nih grants

Papers3,877

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The response mechanism of mandarin fish (Siniperca chuatsi) astrocyte-like cells to SCRV infection: Insights from Transcriptome Sequencing.Fish Shellfish Immunol202642815866PubTator, text miningPubMed
MAVS maintains mitochondrial import competence and also limits RNA virus replication independently of interferon signaling.mBio202642808786PubTator, text miningPubMed
Advances in Cytosolic dsRNA Sensing of Viral Infections.Immunol Cell Biol202642802076PubTator, text miningPubMed
Unraveling the Multifaceted Role of TRIM21 in Virus-Triggered Innate Immunity and Diseases.Biomolecules202642793068PubTator, text miningPubMed
Correction: Foot-and-mouth disease virus non-structural protein 2B downregulates the RLR signaling pathway via degradation of RIG-I and MDA5.Front Immunol202642787502PubTator, text miningPubMed
Extended IL-4 priming of macrophages induces an antiviral state that restricts lymphocytic choriomeningitis virus replication.Cytokine202642777316PubTator, text miningPubMed
Elevated ISG15 reinforces RIG-I/MDA5-linked macrophage-microglia crosstalk during blood-brain barrier disruption in neuromyelitis optica spectrum disorder.Int Immunopharmacol202642763248PubTator, text miningPubMed
Carriage of the Laboratory of Genetics and Physiology Protein 2 Q425R Variant Reduces Liver Disease Severity in European Patients With Chronic Hepatitis Delta.Aliment Pharmacol Ther202642753128PubTator, text miningPubMed
Autogenous vaccination protects Pacific oysters against OsHV-1 by reshaping the transcriptome.Fish Shellfish Immunol202642722176PubTator, text miningPubMed
Post-translational control of MAVS signaling: linking mitochondrial antiviral immunity to metabolic and cellular stress contexts.Front Physiol202642719470PubTator, text miningPubMed

1 to 10 of 3,877

See all 3,877 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/79132

GET https://conductscience.org/api/genes/v1/79132/patents?page=2