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Gene · 7915

ALDH5A1: aldehyde dehydrogenase 5 family member A1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ALDH5A1: aldehyde dehydrogenase 5 family member A1. Genes, record 7915. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7915

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Gene

Symbol
ALDH5A1
HGNC
Name
aldehyde dehydrogenase 5 family member A1
HGNC
NCBI Gene ID
7915
NCBI Gene
HGNC ID
HGNC:408
HGNC
Ensembl
ENSG00000112294
NCBI Gene
Aliases
SSADH, SSDH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51649Succinate-semialdehyde dehydrogenase, mitochondrial5355Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437042P51649Espacenet
EP 4641201 A22025-10-297421P51649Espacenet
JP 2025517969 A2025-06-127421P51649Espacenet
JP 2025062604 A2025-04-143926P51649Espacenet
US 11446398 B22022-09-203926P51649Espacenet
JP 2022524081 A2022-04-27106897P51649Espacenet
JP 2019054813 A2019-04-11217477P51649Espacenet
JP 2017121241 A2017-07-13217477P51649Espacenet
US 9370506 B22016-06-216P51649Espacenet
JP 2015155410 A2015-08-276P51649Espacenet

1 to 10 of 31

See all 31 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIVALPROEX SODIUMCHEMBL2105613Succinate semialdehyde dehydrogenase inhibitorINHIBITORChEMBL
VALPROATE SODIUMCHEMBL433Succinate semialdehyde dehydrogenase inhibitorINHIBITORChEMBL
VALPROIC ACIDCHEMBL109Succinate semialdehyde dehydrogenase inhibitorINHIBITORChEMBL

Trials225

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07226141VALPROIC ACIDPHASE1/PHASE2ClinicalTrials.gov
NCT07052136VALPROIC ACIDClinicalTrials.gov
NCT07046676VALPROIC ACIDPHASE4ClinicalTrials.gov
NCT06714357VALPROIC ACIDPHASE2ClinicalTrials.gov
NCT06549426VALPROIC ACIDClinicalTrials.gov
NCT06393309VALPROIC ACIDClinicalTrials.gov
NCT06248931VALPROIC ACIDPHASE3ClinicalTrials.gov
NCT06199557VALPROIC ACIDPHASE1/PHASE2ClinicalTrials.gov
NCT06020898VALPROIC ACIDPHASE2ClinicalTrials.gov
NCT05973786VALPROIC ACIDPHASE3ClinicalTrials.gov

1 to 10 of 225

See all 225 trials

NIH grants693

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleALDH5A1 papersNewest fiscal year
R01HD091142Natural History of Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD), a Heritable Disorder of GABA Metabolism152025
R01AA011147Ethanol and aldehyde dehydrogenases in health and disease52025
P30CA046934University of Colorado Cancer Center Support Grant32025
P50HD027802Differential Diagnosis in Learning Disabilities32025
P50HD105351Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center32025
R01GM065546Substrate Channeling and Communication in Proline Metabolic Enzymes32025
P01AG005842Understanding and Improving Healthcare Decision-Making and Outcomes for People Living with Alzheimer's Disease and Related Dementias22025
P30CA047904Cancer Center Support Grant22025
P30CA124435Stanford Cancer Institute22025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant22025

1 to 10 of 693Source NIH's project files

See all 693 nih grants

Papers818

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Deciphering the molecular impact of ALDH5A1 missense variants in succinic semialdehyde dehydrogenase deficiency through combined in vitro and in silico approaches.Sci Rep202642469357PubTator, text miningPubMed
Succinic semialdehyde dehydrogenase deficiency: exploring the relationship between ALDH5A1 variants and molecular effect on SSADH.Orphanet J Rare Dis202642218553PubTator, text miningPubMed
ALDH5A1 as a key in osteonecrosis of the femoral head: Insights from bioinformatics and experimental validation.Biomed Rep202641930101PubTator, text miningPubMed
Postnatal gene restoration in succinic semialdehyde dehydrogenase deficiency (SSADHD) reveals phenotype reversibility.bioRxiv202641928951PubTator, text miningPubMed
Heterogeneity of monogenic epilepsy in loci, phenotypes, and treatment approaches.Neurol Sci202641912906PubTator, text miningPubMed
Proteomics signature of moderate-to-vigorous physical activity and risk of multimorbidity of cancer and cardiometabolic diseases.Commun Med (Lond)202641826625PubTator, text miningPubMed
Selective inhibition of ALDH1A3 impedes breast cancer growth and metastasis by blocking ALDH1A3-driven transcriptional programs.iScience202641797928PubTator, text miningPubMed
Bioinformatics Analysis Reveals ALDH5A1: A Novel Molecular Brake on Th17 Cell Pathogenicity in Systemic Lupus Erythematosus.FASEB J202641797515PubTator, text miningPubMed
Molecular mechanisms in podocytopathies: finding suitable targets for a new era of glomerular gene therapy.Clin Kidney J202641788620PubTator, text miningPubMed
Myoclonus in Pediatric Metabolic Diseases: Clinical Spectrum, Mechanisms, and Treatable Causes-A Systematic Review.Metabolites202641745581PubTator, text miningPubMed

1 to 10 of 818

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7915

GET https://conductscience.org/api/genes/v1/7915/patents?page=2