Gene · 7915
ALDH5A1: aldehyde dehydrogenase 5 family member A1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ALDH5A1: aldehyde dehydrogenase 5 family member A1. Genes, record 7915. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7915
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | 535 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 37042 | P51649 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7421 | P51649 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7421 | P51649 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 3926 | P51649 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 3926 | P51649 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 106897 | P51649 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 217477 | P51649 | Espacenet |
| JP 2017121241 A | 2017-07-13 | 217477 | P51649 | Espacenet |
| US 9370506 B2 | 2016-06-21 | 6 | P51649 | Espacenet |
| JP 2015155410 A | 2015-08-27 | 6 | P51649 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials225
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07226141 | VALPROIC ACID | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07052136 | VALPROIC ACID | ClinicalTrials.gov | ||
| NCT07046676 | VALPROIC ACID | PHASE4 | ClinicalTrials.gov | |
| NCT06714357 | VALPROIC ACID | PHASE2 | ClinicalTrials.gov | |
| NCT06549426 | VALPROIC ACID | ClinicalTrials.gov | ||
| NCT06393309 | VALPROIC ACID | ClinicalTrials.gov | ||
| NCT06248931 | VALPROIC ACID | PHASE3 | ClinicalTrials.gov | |
| NCT06199557 | VALPROIC ACID | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT06020898 | VALPROIC ACID | PHASE2 | ClinicalTrials.gov | |
| NCT05973786 | VALPROIC ACID | PHASE3 | ClinicalTrials.gov |
1 to 10 of 225
See all 225 trialsNIH grants693
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ALDH5A1 papers | Newest fiscal year |
|---|---|---|---|
| R01HD091142 | Natural History of Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD), a Heritable Disorder of GABA Metabolism | 15 | 2025 |
| R01AA011147 | Ethanol and aldehyde dehydrogenases in health and disease | 5 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 3 | 2025 |
| P50HD027802 | Differential Diagnosis in Learning Disabilities | 3 | 2025 |
| P50HD105351 | Boston Children's Hospital/HMS Intellectual and Developmental Disabilities Research Center | 3 | 2025 |
| R01GM065546 | Substrate Channeling and Communication in Proline Metabolic Enzymes | 3 | 2025 |
| P01AG005842 | Understanding and Improving Healthcare Decision-Making and Outcomes for People Living with Alzheimer's Disease and Related Dementias | 2 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 2 | 2025 |
| P30CA124435 | Stanford Cancer Institute | 2 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 693Source NIH's project files
See all 693 nih grantsPapers818
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Deciphering the molecular impact of ALDH5A1 missense variants in succinic semialdehyde dehydrogenase deficiency through combined in vitro and in silico approaches. | Sci Rep | 2026 | 42469357 | PubTator, text mining | PubMed |
| Succinic semialdehyde dehydrogenase deficiency: exploring the relationship between ALDH5A1 variants and molecular effect on SSADH. | Orphanet J Rare Dis | 2026 | 42218553 | PubTator, text mining | PubMed |
| ALDH5A1 as a key in osteonecrosis of the femoral head: Insights from bioinformatics and experimental validation. | Biomed Rep | 2026 | 41930101 | PubTator, text mining | PubMed |
| Postnatal gene restoration in succinic semialdehyde dehydrogenase deficiency (SSADHD) reveals phenotype reversibility. | bioRxiv | 2026 | 41928951 | PubTator, text mining | PubMed |
| Heterogeneity of monogenic epilepsy in loci, phenotypes, and treatment approaches. | Neurol Sci | 2026 | 41912906 | PubTator, text mining | PubMed |
| Proteomics signature of moderate-to-vigorous physical activity and risk of multimorbidity of cancer and cardiometabolic diseases. | Commun Med (Lond) | 2026 | 41826625 | PubTator, text mining | PubMed |
| Selective inhibition of ALDH1A3 impedes breast cancer growth and metastasis by blocking ALDH1A3-driven transcriptional programs. | iScience | 2026 | 41797928 | PubTator, text mining | PubMed |
| Bioinformatics Analysis Reveals ALDH5A1: A Novel Molecular Brake on Th17 Cell Pathogenicity in Systemic Lupus Erythematosus. | FASEB J | 2026 | 41797515 | PubTator, text mining | PubMed |
| Molecular mechanisms in podocytopathies: finding suitable targets for a new era of glomerular gene therapy. | Clin Kidney J | 2026 | 41788620 | PubTator, text mining | PubMed |
| Myoclonus in Pediatric Metabolic Diseases: Clinical Spectrum, Mechanisms, and Treatable Causes-A Systematic Review. | Metabolites | 2026 | 41745581 | PubTator, text mining | PubMed |
1 to 10 of 818
See all 818 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7915
GET https://conductscience.org/api/genes/v1/7915/patents?page=2