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Gene · 79400

NOX5: NADPH oxidase 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NOX5: NADPH oxidase 5. Genes, record 79400. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/79400

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Gene

Symbol
NOX5
HGNC
Name
NADPH oxidase 5
HGNC
NCBI Gene ID
79400
NCBI Gene
HGNC ID
HGNC:14874
HGNC
Ensembl
ENSG00000255346
NCBI Gene
Aliases
NOX5A, NOX5B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96PH1NADPH oxidase 57655Ensembl, GeneID, HGNC

Source UniProt

Patents11

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455020Q96PH1Espacenet
EP 4641201 A22025-10-2911023Q96PH1Espacenet
JP 2025529142 A2025-09-042869Q96PH1Espacenet
US 12371689 B22025-07-292869Q96PH1Espacenet
JP 2025517969 A2025-06-1211023Q96PH1Espacenet
US 11446398 B22022-09-2055310Q96PH1Espacenet
US 11400116 B22022-08-025035Q96PH1Espacenet
JP 2022524081 A2022-04-27158281Q96PH1Espacenet
JP 2019054813 A2019-04-11235455Q96PH1Espacenet
JP 2017121241 A2017-07-13235455Q96PH1Espacenet

1 to 10 of 11

See all 11 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants968

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNOX5 papersNewest fiscal year
ZIABC010677NADPH Oxidases as Novel Targets for Cancer Therapy92025
ZIAAI000947Mosquito Immune Responses and Malaria Transmission72025
P30CA016672Cancer Center Support Grant52025
P30CA054174Mays Cancer Center at UT Health SA52025
R01HL125926Galectin-3: A mediator of vascular remodeling in pulmonary arterial hypertension52025
P30AG013319San Antonio Nathan Shock Center of Excellence in the Biology of Aging42025
P50AA011999Southern California Research Center for ALPD and Cirrhosis32025
R01EY015130Mechanisms of Angiogenesis in ROP32025
R01EY017011Endothelial Transmigration in Neovascular Age-related Macular Degeneration32025
R01GM102187Chemical Tools for Probing Cysteine Sulfenation and Sulfination Redox Biology32025

1 to 10 of 968Source NIH's project files

See all 968 nih grants

Papers1,709

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
An Early Value Assessment of Biomarker-Guided Precision Medicine for Treatment-Resistant Hypertension: A Headroom and Threshold Analysis.Appl Health Econ Health Policy202642814264PubTator, text miningPubMed
F-actin-dependent activation of NADPH oxidase 5 by the vacuolar-type ATPase.J Biol Chem202642727851PubTator, text miningPubMed
Dietary Chlorogenic Acid Attenuates Liver Injury, Lipid Metabolic Disturbance, and Inflammatory Responses in Broilers Under High Stocking Density.Animals (Basel)202642651958PubTator, text miningPubMed
Development of a first-in-class homolog-selective, covalent NOX4 inhibitor.Biomed Pharmacother202642600360PubTator, text miningPubMed
Disrupting Redox Balance: A Redox-Based Strategy to Combat Temozolomide Resistance in Glioblastoma.Anticancer Agents Med Chem202642337877PubTator, text miningPubMed
Structural bioinformatic studies of eight integral transmembrane NADPH oxidases and their AlphaFold 3 predicted QTY analogs with reduced hydrophobicity.PLoS One202642268815PubTator, text miningPubMed
Molecular Advances in Male Infertility and Fertility: Importance of Redox Regulation and Oxidative Stress.Int J Mol Sci202642123404PubTator, text miningPubMed
Drugst.One DREAM-Drug repurposing through expert annotation and modification.Br J Pharmacol202642108670PubTator, text miningPubMed
WITHDRAWN: Corrigendum to "NADPH oxidase 5 promotes adhesion and infiltration of immune cells in the brain. Implications in ischemic stroke" [Biochim. Biophys. Acta (BBA) - Mol. Basis Dis. (2026) volume 1872, issue 4, 168188].
Biochim Biophys Acta Mol Basis Dis202642020255PubTator, text miningPubMed
Single-Cell sequencing investigation of endoplasmic reticulum stress-related genes in gastric cancer prognostic models and identification of NOX5 as a novel therapeutic target.Transl Oncol202642013548PubTator, text miningPubMed

1 to 10 of 1,709

See all 1,709 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/79400

GET https://conductscience.org/api/genes/v1/79400/patents