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Gene · 79577

CDC73: cell division cycle 73

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CDC73: cell division cycle 73. Genes, record 79577. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/79577

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Gene

Symbol
CDC73
HGNC
Name
cell division cycle 73
HGNC
NCBI Gene ID
79577
NCBI Gene
HGNC ID
HGNC:16783
HGNC
Ensembl
ENSG00000134371
NCBI Gene
Aliases
C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX, parafibromin
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q6P1J9Parafibromin53120Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-198231Q6P1J9Espacenet
EP 4641201 A22025-10-298400Q6P1J9Espacenet
JP 2025517969 A2025-06-128400Q6P1J9Espacenet
JP 2025517970 A2025-06-128231Q6P1J9Espacenet
JP 2024123008 A2024-09-105535Q6P1J9Espacenet
JP 2023106701 A2023-08-0215Q6P1J9Espacenet
US 11446398 B22022-09-2013762Q6P1J9Espacenet
JP 2022524081 A2022-04-27116733Q6P1J9Espacenet
US 11078247 B22021-08-031889Q6P1J9Espacenet
WO 2020043864 A12020-03-05415Q6P1J9Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants845

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCDC73 papersNewest fiscal year
ZIADK043012Clinical Investigation of FIHP, Parathyroid Cancer & the HPT-JT Syndrome202025
P30CA016672Cancer Center Support Grant122025
ZIADK043006Hyperparathyroidism -- Etiology, Diagnosis and Treatment122025
P30CA008748Cancer Center Support Grant82025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement42025
U10CA180899Children's Oncology Group Statistics and Data Center42025
UL1TR001863Yale Clinical and Translational Science Award42025
ZIADK075035Genes associated with endocrine tumorigenesis42025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)32025
P30CA016086Cancer Center Support Grant32025

1 to 10 of 845Source NIH's project files

See all 845 nih grants

Papers1,751

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Differential tyrosine phosphorylation status of the nuclear scaffold Parafibromin/CDC73 determines its role in cancer development.Biochem Biophys Res Commun202642772177PubTator, text miningPubMed
JNK acts as a molecular brake of the CDC73 positive feedback loop to modulate osteosarcoma malignant progression via UBR5.Oncogene202642749759PubTator, text miningPubMed
Parathyroid carcinoma: epidemiology and genetics.Endocr Oncol202642694707PubTator, text miningPubMed
Management of aggressive forms of primary HPT: Parathyroid carcinoma and atypical parathyroid tumor.J Visc Surg202642580893PubTator, text miningPubMed
Critical Insights into Parathyroid Cancer.J Cancer Sci Clin Ther202642577903PubTator, text miningPubMed
Para This, Fibromin That: The Role of CDC73 in Parathyroid Tumors and Familial Tumor Syndromes.Clin Lab Med202642526972PubTator, text miningPubMed
Determination of the most suitable reference gene for transcription analysis of synovial tissue from osteoarthritis patients.Sci Rep202642469336PubTator, text miningPubMed
Comprehensive genomic profiling and tumor mutational burden in parathyroid carcinoma: a nationwide real-world study from Japan.Endocrine202642455276PubTator, text miningPubMed
A case of CDC73 mutation-related primary hyperparathyroidism with ectopic parathyroid hyperplasia.Proc (Bayl Univ Med Cent)202642454765PubTator, text miningPubMed
Single-cell and spatial transcriptomics define a progenitor subpopulation and fibroinflammatory niche at the leading edge of parathyroid carcinoma.Endocr Relat Cancer202642454544PubTator, text miningPubMed

1 to 10 of 1,751

See all 1,751 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/79577

GET https://conductscience.org/api/genes/v1/79577/patents?page=2