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CALCA: calcitonin related polypeptide alpha

2 proteins, 129 patents, 3 drugs, 50 trials, 5,358 NIH grants and 28,957 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCALCAHGNC
Namecalcitonin related polypeptide alphaHGNC
NCBI Gene ID796NCBI Gene
HGNC IDHGNC:1437HGNC
EnsemblENSG00000110680NCBI Gene
AliasesCALC1, CGRP, CGRP-I, CGRP-alpha, CGRP1, CT, KC, PCTNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 2

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01258Calcitonin1413Ensembl, GeneID, HGNCUniProt
P06881Calcitonin gene-related peptide 11283Ensembl, GeneID, HGNCUniProt

Patents 129

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026209911 A12026-10-0853P06881Espacenet
WO 2025259600 A22025-12-18105P06881Espacenet
EP 4650780 A22025-11-195927P01258Espacenet
EP 4650780 A22025-11-197847P06881Espacenet
JP 2025147176 A2025-10-061986P06881Espacenet
JP 2025147176 A2025-10-061987P06881Espacenet
JP 2025147176 A2025-10-061989P01258Espacenet
JP 2025147176 A2025-10-061990P01258Espacenet
JP 2025529142 A2025-09-045713P06881Espacenet
US 12371689 B22025-07-295713P06881Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EPTINEZUMABCHEMBL3833320Calcitonin gene-related peptide inhibitorINHIBITORChEMBL
FREMANEZUMABCHEMBL4297756Calcitonin gene-related peptide antagonistANTAGONISTChEMBL
GALCANEZUMABCHEMBL3707328Calcitonin gene-related peptide inhibitorINHIBITORChEMBL

Trials 50

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07323927GALCANEZUMABEARLY_PHASE1ClinicalTrials.gov
NCT07250984EPTINEZUMABClinicalTrials.gov
NCT07191145EPTINEZUMABPHASE3ClinicalTrials.gov
NCT07159750GALCANEZUMABClinicalTrials.gov
NCT07159750EPTINEZUMABClinicalTrials.gov
NCT07159750FREMANEZUMABClinicalTrials.gov
NCT07103694GALCANEZUMABClinicalTrials.gov
NCT07103694EPTINEZUMABClinicalTrials.gov
NCT07103694FREMANEZUMABClinicalTrials.gov
NCT07071506FREMANEZUMABClinicalTrials.gov

NIH grants 5358

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant402,025NIH's project files
P30CA016672Cancer Center Support Grant322,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award112,025NIH's project files
P30CA006973Regional Oncology Research Center102,025NIH's project files
P30DA018310Neurometabolomics and Neuroproteomics Center on Cell-Cell Signaling92,025NIH's project files
R01AR060364Molecular Pathways of Pain Generation in Osteoarthritis92,025NIH's project files
R01AR064251Osteoarthritis Progression And Sensory Pathway Alterations92,025NIH's project files
ZIADK053200Diagnosis, Natural History, Management, tumor biology of Gastrinomas/PETs/Neuroendocrine tumors92,025NIH's project files
P30CA015704Cancer Center Support Grant82,025NIH's project files
P30CA044579University of Virginia Cancer Center Support Grant82,025NIH's project files

Papers 28957

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824170PubTator, text miningPubMed
42822051PubTator, text miningPubMed
42820961PubTator, text miningPubMed
42820850PubTator, text miningPubMed
42820849PubTator, text miningPubMed
42818607PubTator, text miningPubMed
42816745PubTator, text miningPubMed
42814346PubTator, text miningPubMed
42814345PubTator, text miningPubMed
42808257PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license