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Gene · 79718

TBL1XR1: TBL1X/Y related 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TBL1XR1: TBL1X/Y related 1. Genes, record 79718. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/79718

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Gene

Symbol
TBL1XR1
HGNC
Name
TBL1X/Y related 1
HGNC
NCBI Gene ID
79718
NCBI Gene
HGNC ID
HGNC:29529
HGNC
Ensembl
ENSG00000177565
NCBI Gene
Aliases
C21, DC42, FLJ12894, IRA1, MRD41, TBLR1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9BZK7F-box-like/WD repeat-containing protein TBL1XR15141Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192276Q9BZK7Espacenet
EP 4641201 A22025-10-291848Q9BZK7Espacenet
JP 2025532979 A2025-10-03184Q9BZK7Espacenet
EP 4593850 A22025-08-06184Q9BZK7Espacenet
JP 2025517969 A2025-06-121848Q9BZK7Espacenet
JP 2025517970 A2025-06-122276Q9BZK7Espacenet
US 12295971 B22025-05-13184Q9BZK7Espacenet
US 11564998 B22023-01-317611Q9BZK7Espacenet
US 11564998 B22023-01-318197Q9BZK7Espacenet
US 11446398 B22022-09-2089961Q9BZK7Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,294

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTBL1XR1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant132025
P30CA021765Cancer Center Support Grant (CCSG)112025
P30CA016672Cancer Center Support Grant82025
P30CA016087Cancer Center Support Grant72025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant52025
P50CA058223SPORE in Breast Cancer52025
ZIASC000550Lymphoma Disease Discovery and Definition52025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant42025
P30CA047904Cancer Center Support Grant42025
R01MH101221Rare Mutations and Autism Spectrum Disorders42025

1 to 10 of 1,294Source NIH's project files

See all 1,294 nih grants

Papers1,924

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dysregulated expression of the EMX2OS/miR-34c-5p/TBL1XR1 regulatory axis: a novel signature for severe community-acquired pneumonia in children.BMC Pediatr202642750020PubTator, text miningPubMed
Nodal marginal zone lymphoma: genetic analysis and the differential diagnosis from other small B-cell lymphomas.Blood Adv202642721462PubTator, text miningPubMed
Expanding the TBL1XR1 Disease Spectrum: Generalized Dystonia Associated with a New Genetic Variant.Tremor Other Hyperkinet Mov (N Y)202642699641PubTator, text miningPubMed
A genome-wide map of the genetic network in monocytes that regulates type I interferon induction by the cGAS-STING pathway.Sci Signal202642611972PubTator, text miningPubMed
Erratum: [Corrigendum] TBL1XR1 as a potential therapeutic target that promotes epithelial-mesenchymal transition in lung squamous cell carcinoma.Exp Ther Med202642577676PubTator, text miningPubMed
Molecular Feasibility of Gene Sequencing on Lymph Node Fine-Needle Cytology Samples of Non-Hodgkin Lymphoma.Int J Mol Sci202642450228PubTator, text miningPubMed
TBL1XR1 mutations promoted tumor progression in diffuse large B-cell lymphoma through impairing nature killer cytotoxicity via the MYC-CD47/PD-L1 axis.Mol Cancer202642436518PubTator, text miningPubMed
Kidney failure in a child with Pierpont syndrome: a case report highlight challenges in kidney replacement therapy.BMC Nephrol202642365304PubTator, text miningPubMed
A Novel De Novo Frameshift Variant of TBL1XR1 Leads to Neurodevelopmental Disorders and Treatment Experience.Int J Dev Neurosci202642281549PubTator, text miningPubMed
Dysfunction of a SET3-like complex underlies a family of related neurological disorders.Nat Commun202642143056PubTator, text miningPubMed

1 to 10 of 1,924

See all 1,924 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/79718

GET https://conductscience.org/api/genes/v1/79718/patents?page=2