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GSDMD: gasdermin D

1 protein, 51 patents, 0 drugs, 0 trials, 1,643 NIH grants and 5,579 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolGSDMDHGNC
Namegasdermin DHGNC
NCBI Gene ID79792NCBI Gene
HGNC IDHGNC:25697HGNC
EnsemblENSG00000104518NCBI Gene
AliasesDF5L, DFNA5L, FKSG10, FLJ12150, GSDMDC1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P57764Gasdermin-D48411Ensembl, GeneID, HGNCUniProt

Patents 51

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026508175 A2026-03-10185P57764Espacenet
EP 4650780 A22025-11-192093P57764Espacenet
WO 2025235876 A22025-11-1326P57764Espacenet
WO 2025132695 A12025-06-2648P57764Espacenet
JP 2025517970 A2025-06-122093P57764Espacenet
JP 2025516241 A2025-05-27105P57764Espacenet
EP 4514822 A22025-03-05105P57764Espacenet
JP 2025024198 A2025-02-1912738P57764Espacenet
JP 2025024198 A2025-02-1912740P57764Espacenet
US 12178845 B22024-12-317P57764Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 1643

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01AI124346Innate immune signaling and stress response402,025NIH's project files
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation402,025NIH's project files
R01AI124491NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing262,025NIH's project files
P30CA008748Cancer Center Support Grant222,025NIH's project files
R35CA253095Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer222,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology152,025NIH's project files
R01AI137168Characterizing the Mechanism of DPP8/9 Inhibitor-Induced Pyroptosis152,025NIH's project files
R01AI160179Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases142,025NIH's project files
R01HL136389The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis122,025NIH's project files
T32AI089474Immunology Training Program-Predoctoral102,025NIH's project files

Papers 5579

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819011PubTator, text miningPubMed
42818881PubTator, text miningPubMed
42815265PubTator, text miningPubMed
42812611PubTator, text miningPubMed
42810779PubTator, text miningPubMed
42807349PubTator, text miningPubMed
42801391PubTator, text miningPubMed
42801360PubTator, text miningPubMed
42800691PubTator, text miningPubMed
42798129PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license