Gene · 7980
TFPI2: tissue factor pathway inhibitor 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. TFPI2: tissue factor pathway inhibitor 2. Genes, record 7980. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7980
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P48307 | Tissue factor pathway inhibitor 2 | 235 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents108
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026000906 A | 2026-01-06 | 188 | P48307 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 562 | P48307 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 13147 | P48307 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7868 | P48307 | Espacenet |
| WO 2025176817 A1 | 2025-08-28 | 51 | P48307 | Espacenet |
| EP 4606910 A1 | 2025-08-27 | 51 | P48307 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7868 | P48307 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 562 | P48307 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 13147 | P48307 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 13147 | P48307 | Espacenet |
1 to 10 of 108
See all 108 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,270
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | TFPI2 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHD002400 | The Role Of Subclinical Infection And Cytokines In Preterm Parturition | 10 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 6 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 5 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 3 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 3 | 2025 |
| P30CA138292 | Winship Cancer Institute Cancer Center Support Grant | 3 | 2025 |
| R01NS059690 | Molecular Chaperones and Small Molecules | 3 | 2025 |
1 to 10 of 1,270Source NIH's project files
See all 1,270 nih grantsPapers2,421
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Dysregulation of the Heparanase/TFPI-2/Heparan Sulfate Axis in Recurrent Pregnancy Loss. | Int J Mol Sci | 2026 | 42794639 | PubTator, text mining | PubMed |
| TNFα-induced endothelial extracellular vesicles regulate astrocyte function: an integrated transcriptomic and proteomic study. | Fluids Barriers CNS | 2026 | 42745340 | PubTator, text mining | PubMed |
| FOXO4 enhances high glucose-induced HK-2 cell damage and inflammation by targeting TFPI2 in diabetic nephropathy. | Kidney Res Clin Pract | 2026 | 42619388 | PubTator, text mining | PubMed |
| Modulating phosphorylation by proximity-inducing strategy: an update. | RSC Med Chem | 2026 | 42582980 | PubTator, text mining | PubMed |
| TFPI2 promotes NK cell-mediated glioblastoma killing through adhesion and checkpoint control. | Proc Natl Acad Sci U S A | 2026 | 42313930 | PubTator, text mining | PubMed |
| TFPI2 in tumor metastasis: a double-edged sword with clinical implications. | Cancer Biol Ther | 2026 | 42216563 | PubTator, text mining | PubMed |
| TFPI2 expression predicts resistance to immunotherapy plus tyrosine kinase inhibitor and informs first-line therapy selection in metastatic renal cell carcinoma. | Cell Oncol (Dordr) | 2026 | 42171882 | PubTator, text mining | PubMed |
| Uncovering a feedback loop in glioblastoma that reinforces stemness and immunosuppression. | J Clin Invest | 2026 | 42138075 | PubTator, text mining | PubMed |
| A novel prognostic signature based on epithelial-mesenchymal transition-associated genes for the prognosis and immune status in breast cancer. | Am J Transl Res | 2026 | 42007152 | PubTator, text mining | PubMed |
| Trophoblast KHSRP deficiency induces DNA damage and apoptosis via TFPI2 in unexplained spontaneous miscarriage. | Placenta | 2026 | 41932065 | PubTator, text mining | PubMed |
1 to 10 of 2,421
See all 2,421 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/7980
GET https://conductscience.org/api/genes/v1/7980/patents?page=2