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Gene · 7980

TFPI2: tissue factor pathway inhibitor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TFPI2: tissue factor pathway inhibitor 2. Genes, record 7980. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7980

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Gene

Symbol
TFPI2
HGNC
Name
tissue factor pathway inhibitor 2
HGNC
NCBI Gene ID
7980
NCBI Gene
HGNC ID
HGNC:11761
HGNC
Ensembl
ENSG00000105825
NCBI Gene
Aliases
PP5, REF1, TFPI-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P48307Tissue factor pathway inhibitor 22351Ensembl, GeneID, HGNC

Source UniProt

Patents108

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026000906 A2026-01-06188P48307Espacenet
EP 4650780 A22025-11-19562P48307Espacenet
JP 2025147176 A2025-10-0613147P48307Espacenet
JP 2025529142 A2025-09-047868P48307Espacenet
WO 2025176817 A12025-08-2851P48307Espacenet
EP 4606910 A12025-08-2751P48307Espacenet
US 12371689 B22025-07-297868P48307Espacenet
JP 2025517970 A2025-06-12562P48307Espacenet
JP 2025028160 A2025-02-2813147P48307Espacenet
KR 1020250010750 A2025-01-2113147P48307Espacenet

1 to 10 of 108

See all 108 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,270

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTFPI2 papersNewest fiscal year
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition102025
P30CA015704Cancer Center Support Grant62025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant52025
P30CA006973Regional Oncology Research Center42025
P30CA008748Cancer Center Support Grant42025
P30AI027763UCSF-Bay Area Center for AIDS Research32025
P30CA021765Cancer Center Support Grant (CCSG)32025
P30CA086862Cancer Center Support Grant32025
P30CA138292Winship Cancer Institute Cancer Center Support Grant32025
R01NS059690Molecular Chaperones and Small Molecules32025

1 to 10 of 1,270Source NIH's project files

See all 1,270 nih grants

Papers2,421

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dysregulation of the Heparanase/TFPI-2/Heparan Sulfate Axis in Recurrent Pregnancy Loss.Int J Mol Sci202642794639PubTator, text miningPubMed
TNFα-induced endothelial extracellular vesicles regulate astrocyte function: an integrated transcriptomic and proteomic study.Fluids Barriers CNS202642745340PubTator, text miningPubMed
FOXO4 enhances high glucose-induced HK-2 cell damage and inflammation by targeting TFPI2 in diabetic nephropathy.Kidney Res Clin Pract202642619388PubTator, text miningPubMed
Modulating phosphorylation by proximity-inducing strategy: an update.RSC Med Chem202642582980PubTator, text miningPubMed
TFPI2 promotes NK cell-mediated glioblastoma killing through adhesion and checkpoint control.Proc Natl Acad Sci U S A202642313930PubTator, text miningPubMed
TFPI2 in tumor metastasis: a double-edged sword with clinical implications.Cancer Biol Ther202642216563PubTator, text miningPubMed
TFPI2 expression predicts resistance to immunotherapy plus tyrosine kinase inhibitor and informs first-line therapy selection in metastatic renal cell carcinoma.Cell Oncol (Dordr)202642171882PubTator, text miningPubMed
Uncovering a feedback loop in glioblastoma that reinforces stemness and immunosuppression.J Clin Invest202642138075PubTator, text miningPubMed
A novel prognostic signature based on epithelial-mesenchymal transition-associated genes for the prognosis and immune status in breast cancer.Am J Transl Res202642007152PubTator, text miningPubMed
Trophoblast KHSRP deficiency induces DNA damage and apoptosis via TFPI2 in unexplained spontaneous miscarriage.Placenta202641932065PubTator, text miningPubMed

1 to 10 of 2,421

See all 2,421 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7980

GET https://conductscience.org/api/genes/v1/7980/patents?page=2