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Gene · 7984

ARHGEF5: Rho guanine nucleotide exchange factor 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ARHGEF5: Rho guanine nucleotide exchange factor 5. Genes, record 7984. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/7984

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Gene

Symbol
ARHGEF5
HGNC
Name
Rho guanine nucleotide exchange factor 5
HGNC
NCBI Gene ID
7984
NCBI Gene
HGNC ID
HGNC:13209
HGNC
Ensembl
ENSG00000050327
NCBI Gene
Aliases
GEF5, P60, TIM, TIM1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q12774Rho guanine nucleotide exchange factor 51,5970Ensembl, GeneID, HGNC

Source UniProt

Patents12

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1461817Q12774Espacenet
EP 4641201 A22025-10-2966Q12774Espacenet
JP 2025517969 A2025-06-1266Q12774Espacenet
KR 1020240173306 A2024-12-111Q12774Espacenet
US 11446398 B22022-09-2073541Q12774Espacenet
JP 2022524081 A2022-04-27176512Q12774Espacenet
US 11078247 B22021-08-03746Q12774Espacenet
KR 1020210040921 A2021-04-142Q12774Espacenet
KR 1020200104106 A2020-09-032Q12774Espacenet
JP 2019054813 A2019-04-11242252Q12774Espacenet

1 to 10 of 12

See all 12 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,350

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleARHGEF5 papersNewest fiscal year
R01GM061721BIOGENESIS OF THE MITOCHONDRIAL INNER MEMBRANE82025
P30CA008748Cancer Center Support Grant62025
P30GM124169ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)42025
R01NS084412Molecular Genetic Analysis of TORC1 and TORC2 Signaling in Neuronal Maintenance42025
P30CA013330Cancer Center Support Grant32025
P30CA068485Cancer Center Support Grant32025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
R01NS048471Interaction between circadian and sleep circuits32025
P01AI106695Protective immunity following dengue virus natural infections and vaccination22025
P20GM103436IDeA Networks of Biomedical Research Excellence in Kentucky22025

1 to 10 of 1,350Source NIH's project files

See all 1,350 nih grants

Papers2,005

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mitochondria and associated complexes as therapeutic targets in aging: From biomacromolecular structure-function insights to clinical translation.Mitochondrion202642822579PubTator, text miningPubMed
Comparative evaluation of USP II, USP IV, TIM-2, and the dynamic colon model as surrogates for human colonic drug dissolution.RSC Pharm202642775266PubTator, text miningPubMed
[China Wumeng Mountain Lung Cancer: Evidence Chain, Clinical and Molecular Characteristics of Regional Lung Cancer Related to Coal Pollution in the Yunnan-Guizhou Plateau].Zhongguo Fei Ai Za Zhi202642634456PubTator, text miningPubMed
Three catalytic frameworks, one engineering logic: Bottlenecks and design levers in pesticide-degrading hydrolases.Biotechnol Adv202642456795PubTator, text miningPubMed
Customizing the structure of minimal TIM barrels to craft efficient de novo enzymes.Nat Chem Biol202642297966PubTator, text miningPubMed
Myeloid Malignancies Beyond the Cell: Targeting the Tumour Microenvironment with Next-Generation Immunotherapies.Cancers (Basel)202642279389PubTator, text miningPubMed
Revealing biological mechanisms of skin pigment recovery during treatment in vitiligo patients: A proteomic analysis.J Invest Dermatol202642235790PubTator, text miningPubMed
Stability and cooperativity in chimeric de novo TIM barrels via quarter swapping.Protein Sci202642080298PubTator, text miningPubMed
TIM-1 and Tiny-TIM as Robust In Vitro Models for Oral Biopharmaceutics: Evidence from an International Ring Study.Pharmaceutics202642076053PubTator, text miningPubMed
Periodontitis Primes the Oral Microenvironment for PS-Dependent Non-Canonical Entry Pathways Linked to SARS-CoV-2 Susceptibility.Res Sq202642040960PubTator, text miningPubMed

1 to 10 of 2,005

See all 2,005 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/7984

GET https://conductscience.org/api/genes/v1/7984/patents