ConductScience.org, home

Gene · 79840

NHEJ1: non-homologous end joining factor 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. NHEJ1: non-homologous end joining factor 1. Genes, record 79840. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/79840

On this page

Gene

Symbol
NHEJ1
HGNC
Name
non-homologous end joining factor 1
HGNC
NCBI Gene ID
79840
NCBI Gene
HGNC ID
HGNC:25737
HGNC
Ensembl
ENSG00000187736
NCBI Gene
Aliases
Cernunnos, FLJ12610, IMD124, MCOPCB13, XLF
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H9Q4Non-homologous end-joining factor 129927Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455879Q9H9Q4Espacenet
EP 4650780 A22025-11-197357Q9H9Q4Espacenet
JP 2025517970 A2025-06-127357Q9H9Q4Espacenet
EP 4464338 A22024-11-20290Q9H9Q4Espacenet
US 11860162 B22024-01-021221Q9H9Q4Espacenet
US 11680268 B22023-06-20290Q9H9Q4Espacenet
US 11446398 B22022-09-2057560Q9H9Q4Espacenet
JP 2022524081 A2022-04-27160531Q9H9Q4Espacenet
US 11078247 B22021-08-037464Q9H9Q4Espacenet
US 10746735 B22020-08-181221Q9H9Q4Espacenet

1 to 10 of 20

See all 20 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants860

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNHEJ1 papersNewest fiscal year
P01CA092584Structural Cell Biology of DNA Repair Machines532025
R35GM118009Site-Specific Recombination in Human Health & Disease152025
P30CA008748Cancer Center Support Grant72025
P30CA016672Cancer Center Support Grant72025
P30CA033572Cancer Center Support Grant72025
R13AI094943Annual Primary Immune Deficiency Treatment Consortium (PIDTC) Workshop and Education Day62025
P01AG047200Comparative genomics of longevity and Alzheimer's disease52025
P30CA118100University of New Mexico Cancer Center Support Grant52025
R01CA097096DNA Polymerases in Nonhomologous End Joining52025
R01ES005775Oncometabolites, DNA Repair, and Cancer52025

1 to 10 of 860Source NIH's project files

See all 860 nih grants

Papers1,354

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Base editing reversal of radiation sensitivity in NHEJ1 immunodeficiency.J Hum Immun202642690170PubTator, text miningPubMed
Successful Therapy of CNS Tuberculosis With Granulomatous Inflammation in Immunodeficiency.Clin Pediatr (Phila)202642638394PubTator, text miningPubMed
Characterization of a Ku-binding motif in the C-terminal region of RAG2.DNA Repair (Amst)202642585842PubTator, text miningPubMed
A NHEJ1 mutator allele influencing germline mutation rates sex-specifically in humans.Sci Adv202642536752PubTator, text miningPubMed
Case Report: A case series of using whole exome sequencing to detect novel variants in Vietnamese patients with inborn errors of immunity.Front Genet202642283036PubTator, text miningPubMed
HSF1 and YTHDC1 enhance DNA repair under heat stress by promoting repair-associated gene expression.Nucleic Acids Res202642055551PubTator, text miningPubMed
Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities.J Biomed Sci202641928257PubTator, text miningPubMed
An Update on Inborn Errors of V(D)J Recombination.Physiology (Bethesda)202641902554PubTator, text miningPubMed
Indel pattern-guided repair mapping reveals genome-wide DNA repair networks in CRISPR/Cas9 editing.Nucleic Acids Res202641891877PubTator, text miningPubMed
Nonhomologous end joining-the importance of end tethering and beyond.Genes Dev202641871908PubTator, text miningPubMed

1 to 10 of 1,354

See all 1,354 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/79840

GET https://conductscience.org/api/genes/v1/79840/patents