Gene · 79885
HDAC11: histone deacetylase 11
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HDAC11: histone deacetylase 11. Genes, record 79885. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/79885
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96DB2 | Histone deacetylase 11 | 347 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents18
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 3646 | Q96DB2 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3646 | Q96DB2 | Espacenet |
| JP 2024123008 A | 2024-09-10 | 6454 | Q96DB2 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 38563 | Q96DB2 | Espacenet |
| US 11345672 B2 | 2022-05-31 | 13 | Q96DB2 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 141534 | Q96DB2 | Espacenet |
| US 10538496 B2 | 2020-01-21 | 13 | Q96DB2 | Espacenet |
| US 10508088 B2 | 2019-12-17 | 13 | Q96DB2 | Espacenet |
| US 10501513 B2 | 2019-12-10 | 6454 | Q96DB2 | Espacenet |
| JP 2019158777 A | 2019-09-19 | 1031 | Q96DB2 | Espacenet |
1 to 10 of 18
See all 18 patentsDrugs13
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABEXINOSTAT | CHEMBL2103863 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| BELINOSTAT | CHEMBL408513 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| CUDC-101 | CHEMBL598797 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| ENTINOSTAT | CHEMBL27759 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| FIMEPINOSTAT | CHEMBL3622533 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| GIVINOSTAT | CHEMBL1213492 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| GIVINOSTAT HYDROCHLORIDE | CHEMBL6068400 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| MOCETINOSTAT | CHEMBL272980 | Histone deacetylase 11 inhibitor | INHIBITOR | ChEMBL |
| PANOBINOSTAT | CHEMBL483254 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
| PANOBINOSTAT LACTATE | CHEMBL3545368 | Histone deacetylase inhibitor | INHIBITOR | ChEMBL |
1 to 10 of 13
See all 13 drugsTrials410
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07492394 | ENTINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT07441486 | ENTINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT07330544 | ENTINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT07261592 | ENTINOSTAT | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT07235618 | ENTINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT06824662 | QUISINOSTAT | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT06769633 | GIVINOSTAT HYDROCHLORIDE | PHASE2 | ClinicalTrials.gov | |
| NCT06561048 | BELINOSTAT | PHASE3 | ClinicalTrials.gov | |
| NCT06406465 | BELINOSTAT | PHASE2 | ClinicalTrials.gov | |
| NCT06240520 | PANOBINOSTAT | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 410
See all 410 trialsNIH grants1,188
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HDAC11 papers | Newest fiscal year |
|---|---|---|---|
| R01GM049758 | Structure and Function of Metalloenzymes | 21 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 14 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| P30DK048520 | Colorado Nutrition Obesity Research Center | 5 | 2025 |
| P30GM124165 | NE-CAT: A Resource for Advanced Macromolecular Crystallography | 5 | 2025 |
| P30ES005022 | Rutgers Center for Environmental Exposure and Disease (CEED) | 4 | 2025 |
| P01CA108671 | Myeloproliferative Neoplasms-Research Consortium | 3 | 2025 |
| P01CA155258 | Integrative Oncogenomics of Multiple Myeloma | 3 | 2025 |
| P20GM130459 | Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System | 3 | 2025 |
1 to 10 of 1,188Source NIH's project files
See all 1,188 nih grantsPapers2,024
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Structure-guided identification of histone deacetylase 11 inhibitors for targeted chemotherapy through long-timescale molecular dynamics simulation. | J Mol Model | 2026 | 42747587 | PubTator, text mining | PubMed |
| The histone deacetylase family in health and disease. | Signal Transduct Target Ther | 2026 | 42736262 | PubTator, text mining | PubMed |
| Critical structural features of HDAC11 inhibitors. | Methods Enzymol | 2026 | 42692754 | PubTator, text mining | PubMed |
| Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart. | J Precis Med (Amst) | 2026 | 42644057 | PubTator, text mining | PubMed |
| Design, synthesis, and evaluation of anti-solid-tumor activity of niclosamide-based STAT3/HDAC dual-target inhibitors. | Bioorg Chem | 2026 | 42526131 | PubTator, text mining | PubMed |
| AARS1-catalyzed H4K12 lactylation promotes HCC resistance to targeted therapy by activating RAPGEF3-RAP1 signaling. | Cell Death Dis | 2026 | 42481450 | PubTator, text mining | PubMed |
| Distillation enables scalable high-fidelity virtual screening across ultra-large chemical libraries. | bioRxiv | 2026 | 42427611 | PubTator, text mining | PubMed |
| HDAC11 as a potential therapeutic target for Alzheimer's disease. | Drug Discov Today | 2026 | 42398801 | PubTator, text mining | PubMed |
| Integrative transcriptomic and CRISPR dependency analysis identifies hepatoblastoma-specific essential genes and actionable vulnerabilities. | Cancer Genet | 2026 | 42385356 | PubTator, text mining | PubMed |
| Functional divergence and structural changes of Class IV histone deacetylases (HDACs) across the tree of life. | Mol Biol Evol | 2026 | 42308148 | PubTator, text mining | PubMed |
1 to 10 of 2,024
See all 2,024 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/79885
GET https://conductscience.org/api/genes/v1/79885/patents