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Gene · 79885

HDAC11: histone deacetylase 11

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HDAC11: histone deacetylase 11. Genes, record 79885. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/79885

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Gene

Symbol
HDAC11
HGNC
Name
histone deacetylase 11
HGNC
NCBI Gene ID
79885
NCBI Gene
HGNC ID
HGNC:19086
HGNC
Ensembl
ENSG00000163517
NCBI Gene
Aliases
HD11
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96DB2Histone deacetylase 113470Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193646Q96DB2Espacenet
JP 2025517970 A2025-06-123646Q96DB2Espacenet
JP 2024123008 A2024-09-106454Q96DB2Espacenet
US 11446398 B22022-09-2038563Q96DB2Espacenet
US 11345672 B22022-05-3113Q96DB2Espacenet
JP 2022524081 A2022-04-27141534Q96DB2Espacenet
US 10538496 B22020-01-2113Q96DB2Espacenet
US 10508088 B22019-12-1713Q96DB2Espacenet
US 10501513 B22019-12-106454Q96DB2Espacenet
JP 2019158777 A2019-09-191031Q96DB2Espacenet

1 to 10 of 18

See all 18 patents

Drugs13

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEXINOSTATCHEMBL2103863Histone deacetylase inhibitorINHIBITORChEMBL
BELINOSTATCHEMBL408513Histone deacetylase inhibitorINHIBITORChEMBL
CUDC-101CHEMBL598797Histone deacetylase inhibitorINHIBITORChEMBL
ENTINOSTATCHEMBL27759Histone deacetylase inhibitorINHIBITORChEMBL
FIMEPINOSTATCHEMBL3622533Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTATCHEMBL1213492Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTAT HYDROCHLORIDECHEMBL6068400Histone deacetylase inhibitorINHIBITORChEMBL
MOCETINOSTATCHEMBL272980Histone deacetylase 11 inhibitorINHIBITORChEMBL
PANOBINOSTATCHEMBL483254Histone deacetylase inhibitorINHIBITORChEMBL
PANOBINOSTAT LACTATECHEMBL3545368Histone deacetylase inhibitorINHIBITORChEMBL

1 to 10 of 13

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Trials410

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07492394ENTINOSTATPHASE2ClinicalTrials.gov
NCT07441486ENTINOSTATPHASE2ClinicalTrials.gov
NCT07330544ENTINOSTATPHASE2ClinicalTrials.gov
NCT07261592ENTINOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT07235618ENTINOSTATPHASE2ClinicalTrials.gov
NCT06824662QUISINOSTATEARLY_PHASE1ClinicalTrials.gov
NCT06769633GIVINOSTAT HYDROCHLORIDEPHASE2ClinicalTrials.gov
NCT06561048BELINOSTATPHASE3ClinicalTrials.gov
NCT06406465BELINOSTATPHASE2ClinicalTrials.gov
NCT06240520PANOBINOSTATPHASE1/PHASE2ClinicalTrials.gov

1 to 10 of 410

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NIH grants1,188

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHDAC11 papersNewest fiscal year
R01GM049758Structure and Function of Metalloenzymes212025
P30CA076292Moffitt Cancer Center Support Grant142025
P30CA008748Cancer Center Support Grant122025
P30CA016672Cancer Center Support Grant72025
P30DK048520Colorado Nutrition Obesity Research Center52025
P30GM124165NE-CAT: A Resource for Advanced Macromolecular Crystallography52025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)42025
P01CA108671Myeloproliferative Neoplasms-Research Consortium32025
P01CA155258Integrative Oncogenomics of Multiple Myeloma32025
P20GM130459Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System32025

1 to 10 of 1,188Source NIH's project files

See all 1,188 nih grants

Papers2,024

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structure-guided identification of histone deacetylase 11 inhibitors for targeted chemotherapy through long-timescale molecular dynamics simulation.J Mol Model202642747587PubTator, text miningPubMed
The histone deacetylase family in health and disease.Signal Transduct Target Ther202642736262PubTator, text miningPubMed
Critical structural features of HDAC11 inhibitors.Methods Enzymol202642692754PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
Design, synthesis, and evaluation of anti-solid-tumor activity of niclosamide-based STAT3/HDAC dual-target inhibitors.Bioorg Chem202642526131PubTator, text miningPubMed
AARS1-catalyzed H4K12 lactylation promotes HCC resistance to targeted therapy by activating RAPGEF3-RAP1 signaling.Cell Death Dis202642481450PubTator, text miningPubMed
Distillation enables scalable high-fidelity virtual screening across ultra-large chemical libraries.bioRxiv202642427611PubTator, text miningPubMed
HDAC11 as a potential therapeutic target for Alzheimer's disease.Drug Discov Today202642398801PubTator, text miningPubMed
Integrative transcriptomic and CRISPR dependency analysis identifies hepatoblastoma-specific essential genes and actionable vulnerabilities.Cancer Genet202642385356PubTator, text miningPubMed
Functional divergence and structural changes of Class IV histone deacetylases (HDACs) across the tree of life.Mol Biol Evol202642308148PubTator, text miningPubMed

1 to 10 of 2,024

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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