Gene · 8000
PSCA: prostate stem cell antigen
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PSCA: prostate stem cell antigen. Genes, record 8000. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8000
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43653 | Prostate stem cell antigen | 114 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents102
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026012855 A | 2026-01-27 | 31 | O43653 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 59426 | O43653 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 529 | O43653 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3626 | O43653 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 529 | O43653 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3626 | O43653 | Espacenet |
| US 12252547 B2 | 2025-03-18 | 20 | O43653 | Espacenet |
| JP 2025024198 A | 2025-02-19 | 14772 | O43653 | Espacenet |
| EP 4487869 A2 | 2025-01-08 | 416 | O43653 | Espacenet |
| EP 4488293 A2 | 2025-01-08 | 20 | O43653 | Espacenet |
1 to 10 of 102
See all 102 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| MK-4721 | CHEMBL2109548 | Prostate stem cell antigen inhibitor | INHIBITOR |
Source ChEMBL
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT01608711 | MK-4721 | PHASE2 | ClinicalTrials.gov | |
| NCT00902291 | MK-4721 | PHASE2 | ClinicalTrials.gov | |
| NCT00519233 | MK-4721 | PHASE1 | ClinicalTrials.gov |
NIH grants938
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PSCA papers | Newest fiscal year |
|---|---|---|---|
| P30CA016042 | Cancer Center Support Grant | 31 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 28 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 8 | 2025 |
| P50CA092629 | SPORE in Prostate Cancer | 8 | 2025 |
| P50CA097186 | The Pacific Northwest Prostate Cancer SPORE | 8 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 7 | 2025 |
| P50CA126752 | SPORE in Lymphoma | 7 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 938Source NIH's project files
See all 938 nih grantsPapers1,687
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Advances, challenges, and innovative strategies of CAR-T cell therapy in pancreatic cancer. | Biomark Res | 2026 | 42681683 | PubTator, text mining | PubMed |
| Site-Resolved Plasma-Protein Architecture of Infection Susceptibility: A Cis-pQTL Mendelian Randomization and Colocalization Study. | Genes (Basel) | 2026 | 42650080 | PubTator, text mining | PubMed |
| Spatial Transcriptomics of Micropapillary, Plasmacytoid, and Sarcomatoid Urothelial Carcinoma Reveals Distinct Molecular Landscapes. | Lab Invest | 2026 | 42641761 | PubTator, text mining | PubMed |
| A radiotherapy resistance-related prognostic signature predicts survival and the immune landscape in rectal cancer. | Transl Cancer Res | 2026 | 42591449 | PubTator, text mining | PubMed |
| Shared Genetics of Kidney Function Traits and Bladder Cancer: A Genome-Wide Cross-Trait Analysis. | Cancer Med | 2026 | 42470241 | PubTator, text mining | PubMed |
| Development and internal validation of a risk prediction model for gastric precancerous lesions integrating Helicobacter pylori serologic typing and host susceptibility polymorphisms. | Medicine (Baltimore) | 2026 | 42410859 | PubTator, text mining | PubMed |
| nanoASM: Long-Read Allele-Specific DNA Methylation Profiling Enables Functional Annotation of Regulatory Noncoding Variants in Human Prostate Tissues. | bioRxiv | 2026 | 42395488 | PubTator, text mining | PubMed |
| Integrative analysis of gastric tissue transcriptomes and gastric cancer GWAS implicates candidate susceptibility genes. | Am J Hum Genet | 2026 | 42392035 | PubTator, text mining | PubMed |
| Unveiling the Importance of the Expression of LY6/UPAR Gene Family Members in Urothelial Carcinoma of the Urinary Bladder. | Biomedicines | 2026 | 42351767 | PubTator, text mining | PubMed |
| Establishment and validation of a prognostic model for pancreatic cancer utilizing genes of tumor-associated neutrophils. | Discov Oncol | 2026 | 42286393 | PubTator, text mining | PubMed |
1 to 10 of 1,687
See all 1,687 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8000
GET https://conductscience.org/api/genes/v1/8000/patents?page=2