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Gene · 8019

BRD3: bromodomain containing 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. BRD3: bromodomain containing 3. Genes, record 8019. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8019

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Gene

Symbol
BRD3
HGNC
Name
bromodomain containing 3
HGNC
NCBI Gene ID
8019
NCBI Gene
HGNC ID
HGNC:1104
HGNC
Ensembl
ENSG00000169925
NCBI Gene
Aliases
FSHRG2, KIAA0043, ORFX, RING3L
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15059Bromodomain-containing protein 372648Ensembl, GeneID, HGNC

Source UniProt

Patents61

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2025243001 A12025-11-273Q15059Espacenet
EP 4650780 A22025-11-194385Q15059Espacenet
EP 4641201 A22025-10-293922Q15059Espacenet
JP 2025517969 A2025-06-123922Q15059Espacenet
JP 2025517970 A2025-06-124385Q15059Espacenet
JP 2025062604 A2025-04-149833Q15059Espacenet
US 12023385 B22024-07-0214Q15059Espacenet
EP 4119552 A12023-01-1828Q15059Espacenet
US 11446398 B22022-09-209833Q15059Espacenet
JP 2022524081 A2022-04-27112804Q15059Espacenet

1 to 10 of 61

See all 61 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APABETALONECHEMBL2393130Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
BIRABRESIBCHEMBL3581647Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
EZOBRESIBCHEMBL4297458Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
MOLIBRESIBCHEMBL1232461Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
PELABRESIBCHEMBL4303404Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL
RO-6870810CHEMBL4297423Bromodomain and extra-terminal motif (BET) inhibitorINHIBITORChEMBL

Trials42

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07357727PELABRESIBPHASE3ClinicalTrials.gov
NCT07340138PELABRESIBPHASE1ClinicalTrials.gov
NCT06590324APABETALONEPHASE2/PHASE3ClinicalTrials.gov
NCT06401356PELABRESIBPHASE3ClinicalTrials.gov
NCT05372354EZOBRESIBPHASE1/PHASE2ClinicalTrials.gov
NCT04915300APABETALONEPHASE2ClinicalTrials.gov
NCT04894266APABETALONEPHASE2/PHASE3ClinicalTrials.gov
NCT04817007EZOBRESIBPHASE1/PHASE2ClinicalTrials.gov
NCT04603495PELABRESIBPHASE32024-10-28ClinicalTrials.gov
NCT03936465EZOBRESIBPHASE1ClinicalTrials.gov

1 to 10 of 42

See all 42 trials

NIH grants1,701

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleBRD3 papersNewest fiscal year
R01CA124633Pathogenesis and Treatment of NUT midline carcinoma222025
P30CA008748Cancer Center Support Grant172025
P30CA016672Cancer Center Support Grant152025
P30CA021765Cancer Center Support Grant (CCSG)112025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028102025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias92025
P30CA076292Moffitt Cancer Center Support Grant82025
R35CA197589Inducing Proximity: An Emerging Paradigm for New Therapeutic Modalities82025
P30CA006973Regional Oncology Research Center62025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant62025

1 to 10 of 1,701Source NIH's project files

See all 1,701 nih grants

Papers2,104

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MAPK signaling links BRD2 chromatin occupancy to PI3K/AKT inhibitor sensitivity.bioRxiv202642818240PubTator, text miningPubMed
Integrative Proteomics and Ubiquitomics Reveal on-Targets and off-Targets of PROTAC dBET1.Anal Chem202642689581PubTator, text miningPubMed
Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML.Cells202642587822PubTator, text miningPubMed
BRD4: From molecular understanding to therapeutics development.Mol Cell202642492506PubTator, text miningPubMed
Targeting bromodomain and extraterminal proteins in cardiovascular disease: Pathological mechanisms and therapeutic applications.J Int Med Res202642426583PubTator, text miningPubMed
Insights into the Phylogeny and Enigmatic Mitochondrial Biology of Eustigmatophyte Algae From Over 50 Newly Sequenced Organellar Genomes.Genome Biol Evol202642412603PubTator, text miningPubMed
NUT Carcinoma Arising in Stensen's Duct: First Reported Case and Literature Review.Head Neck Pathol202642377811PubTator, text miningPubMed
Epigenetic regulation of cardiac physiology and pathophysiology: biological sex matters.J Cardiovasc Aging202642369572PubTator, text miningPubMed
Unraveling the layers of epigenetic control in respiratory antiviral defense.J Virol202642159289PubTator, text miningPubMed
Temporal genetic changes in human bocavirus 1 in Fukushima, Japan, from 2018 to 2024.J Med Microbiol202642117238PubTator, text miningPubMed

1 to 10 of 2,104

See all 2,104 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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