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Gene · 8030

CCDC6: coiled-coil domain containing 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CCDC6: coiled-coil domain containing 6. Genes, record 8030. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8030

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Gene

Symbol
CCDC6
HGNC
Name
coiled-coil domain containing 6
HGNC
NCBI Gene ID
8030
NCBI Gene
HGNC ID
HGNC:18782
HGNC
Ensembl
ENSG00000108091
NCBI Gene
Aliases
D10S170, H4, PTC, PTC1, TPC, TST1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16204Coiled-coil domain-containing protein 64742Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441821Q16204Espacenet
EP 4650780 A22025-11-192168Q16204Espacenet
JP 2025517970 A2025-06-122168Q16204Espacenet
US 11633402 B22023-04-2532Q16204Espacenet
US 11446398 B22022-09-2018624Q16204Espacenet
JP 2022524081 A2022-04-27121595Q16204Espacenet
US 11078247 B22021-08-031699Q16204Espacenet
US 10668075 B22020-06-0232Q16204Espacenet
WO 2020043864 A12020-03-05400Q16204Espacenet
JP 2019054813 A2019-04-11222256Q16204Espacenet

1 to 10 of 31

See all 31 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
PRALSETINIBCHEMBL4582651Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL
SELPERCATINIBCHEMBL4559134Coiled-coil domain-containing protein 6/Tyrosine-protein kinase receptor RET inhibitorINHIBITORChEMBL

Trials28

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07418879PRALSETINIBClinicalTrials.gov
NCT07146893SELPERCATINIBEARLY_PHASE1ClinicalTrials.gov
NCT06563999PRALSETINIBPHASE2ClinicalTrials.gov
NCT06532149SELPERCATINIBClinicalTrials.gov
NCT06482086PRALSETINIBPHASE2ClinicalTrials.gov
NCT06458036SELPERCATINIBPHASE2ClinicalTrials.gov
NCT05668962SELPERCATINIBPHASE2ClinicalTrials.gov
NCT05364645SELPERCATINIBPHASE2ClinicalTrials.gov
NCT04819100SELPERCATINIBPHASE3ClinicalTrials.gov
NCT04760288PRALSETINIBPHASE3ClinicalTrials.gov

1 to 10 of 28

See all 28 trials

NIH grants1,144

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCCDC6 papersNewest fiscal year
P30CA008748Cancer Center Support Grant462025
P30CA016672Cancer Center Support Grant222025
P30CA016058Cancer Center Support Grant72025
P30CA046934University of Colorado Cancer Center Support Grant72025
P30CA047904Cancer Center Support Grant52025
P30CA068485Cancer Center Support Grant52025
R01CA251591Predicting sensitivity and resistance in RET-driven cancers52025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)52025
R01CA273168Discovery of the next-generation RET-targeted drugs based on nicotinamide scaffold42025
T32CA009207Investigational Cancer Therapeutics Training Program (ICTTP)42025

1 to 10 of 1,144Source NIH's project files

See all 1,144 nih grants

Papers1,913

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The impact of RET fusions on radioiodine avidity and prognosis in patients with distant metastatic papillary thyroid cancer.Endocrine202642804115PubTator, text miningPubMed
Retraction: Loss of CCDC6, the First Identified RET Partner Gene, Affects pH2AX S139 Levels and Accelerates Mitotic Entry upon DNA Damage.PLoS One202642784551PubTator, text miningPubMed
Retraction: Identification of sumoylation sites in CCDC6, the first identified RET partner gene in papillary thyroid carcinoma, uncovers a mode of regulating CCDC6 function on CREB1 transcriptional activity.
PLoS One202642691019PubTator, text miningPubMed
Association between Alzheimer's disease-related genes and neurodegenerative blood-based biomarkers in Indian adults.Front Aging Neurosci202642688218PubTator, text miningPubMed
Nonviral delivery of chemically modified tRNA rescues nonsense mutations in cystic fibrosis.Science202642658930PubTator, text miningPubMed
Sequential EGFR T790M, MET c.3010C>G-Associated Exon 14 Alteration, and RET-CCDC6 Fusion in EGFR-Mutant NSCLC: A Case Report.Thorac Cancer202642503459PubTator, text miningPubMed
Nonsense-mediated mRNA decay as a gatekeeper of neoantigen expression: Bridging RNA surveillance and tumor immunotherapy.Mol Biol Rep202642461475PubTator, text miningPubMed
The regulation of protein phosphatase 4 by FBXO42 is required for cancer cell survival.EMBO Rep202642448956PubTator, text miningPubMed
Holding the PP2A and PP4 protein phosphatases at bay: emerging roles of FBXO42 and CCDC6.EMBO Rep202642448955PubTator, text miningPubMed
KRAS-mediated CCDC6 degradation drives xCT upregulation and ferroptosis evasion.Apoptosis202642448954PubTator, text miningPubMed

1 to 10 of 1,913

See all 1,913 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8030

GET https://conductscience.org/api/genes/v1/8030/patents?page=2