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Gene · 8031

NCOA4: nuclear receptor coactivator 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NCOA4: nuclear receptor coactivator 4. Genes, record 8031. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8031

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Gene

Symbol
NCOA4
HGNC
Name
nuclear receptor coactivator 4
HGNC
NCBI Gene ID
8031
NCBI Gene
HGNC ID
HGNC:7671
HGNC
Ensembl
ENSG00000266412
NCBI Gene
Aliases
ARA70, DKFZp762E1112, ELE1, PTC3, RFG
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13772Nuclear receptor coactivator 46143Ensembl, GeneID, HGNC

Source UniProt

Patents71

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456105Q13772Espacenet
JP 2026004568 A2026-01-1456107Q13772Espacenet
JP 2026004568 A2026-01-1456112Q13772Espacenet
EP 4650780 A22025-11-1917463Q13772Espacenet
JP 2025147176 A2025-10-0615346Q13772Espacenet
JP 2025517970 A2025-06-1217463Q13772Espacenet
JP 2025028160 A2025-02-2815346Q13772Espacenet
JP 2025024198 A2025-02-1914131Q13772Espacenet
JP 2025024198 A2025-02-1914132Q13772Espacenet
JP 2025024198 A2025-02-1914133Q13772Espacenet

1 to 10 of 71

See all 71 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,051

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNCOA4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant362025
P30CA016672Cancer Center Support Grant172025
P30CA047904Cancer Center Support Grant102025
R35GM131919The mechanism and regulation of autophagy82025
T32CA009207Investigational Cancer Therapeutics Training Program (ICTTP)62025
P50CA097186The Pacific Northwest Prostate Cancer SPORE52025
R01CA148828The role of HIF2alpha in colon carcinogenesis52025
R01DK095201Control of iron absorption by intestinal HIF2 in iron and hematological disorders52025
ZIADK054510Identification of human genes of iron homeostasis52025
P30CA006973Regional Oncology Research Center42025

1 to 10 of 1,051Source NIH's project files

See all 1,051 nih grants

Papers3,176

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Anesthesia inhalation agent sevoflurane induces perioperative cognitive impairment: Apelin/early growth response 1 axis induces ferritinophagy and exacerbates ferroptosis.Med Gas Res202742734444PubTator, text miningPubMed
From Genomic Insight to Clinical Impact: Dramatic Response in RET Fusion-positive Pancreatic Cancer.Anticancer Res202642823154PubTator, text miningPubMed
NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1-CH25H Axis.Adv Sci (Weinh)202642811495PubTator, text miningPubMed
The impact of RET fusions on radioiodine avidity and prognosis in patients with distant metastatic papillary thyroid cancer.Endocrine202642804115PubTator, text miningPubMed
Integrated Structural and Dynamic Analysis Reveals Destabilizing Effects of KRAS Missense Variants Associated with Lung Cancer.Protein J202642791474PubTator, text miningPubMed
Biophysical and molecular determinants of NCOA4-mediated ferritinophagy at the ferroptosis-inflammation interface: Compartmental iron transport, lipid oxidation, and causal constraints.Prog Biophys Mol Biol202642759775PubTator, text miningPubMed
Ferroptosis-neuroinflammation interplay: mechanistic pathways and therapeutic opportunities in central nervous system disorders.Front Aging Neurosci202642755568PubTator, text miningPubMed
MicroRNA-Ferroptosis-Spinal Cord Injury: A Complex Interplay in Neurodegeneration and Repair.Int J Mol Sci202642737610PubTator, text miningPubMed
Diagnostic and Predictive Values of Ferroptosis-Related Genes in Endometriosis Based on Integrated Bioinformatic Analysis.Reprod Sci202642728524PubTator, text miningPubMed
FTH1 mRNA-Protein Discordance in Cardiac Ferroptosis: Multilayer Posttranscriptional and Degradative Control.Cardiovasc Ther202642723477PubTator, text miningPubMed

1 to 10 of 3,176

See all 3,176 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8031

GET https://conductscience.org/api/genes/v1/8031/patents?page=2