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Gene · 80339

PNPLA3: patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PNPLA3: patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase. Genes, record 80339. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/80339

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Gene

Symbol
PNPLA3
HGNC
Name
patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase
HGNC
NCBI Gene ID
80339
NCBI Gene
HGNC ID
HGNC:18590
HGNC
Ensembl
ENSG00000100344
NCBI Gene
Aliases
ADPN, C22orf20, FLJ22012, adiponutrin, dJ796I17.1, iPLA(2)epsilon, iPLA2epsilon
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NST11-acylglycerol-3-phosphate O-acyltransferase PNPLA34810Ensembl, GeneID, HGNC

Source UniProt

Patents58

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026016717 A2026-02-0340Q9NST1Espacenet
EP 4685243 A22026-01-2840Q9NST1Espacenet
JP 2026004568 A2026-01-1457147Q9NST1Espacenet
EP 4640849 A22025-10-2937Q9NST1Espacenet
EP 4641201 A22025-10-29235Q9NST1Espacenet
JP 2025519096 A2025-06-2437Q9NST1Espacenet
JP 2025517969 A2025-06-12235Q9NST1Espacenet
US 12286677 B22025-04-2940Q9NST1Espacenet
US 12250931 B22025-03-185Q9NST1Espacenet
JP 2025032204 A2025-03-1133798Q9NST1Espacenet

1 to 10 of 58

See all 58 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,853

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePNPLA3 papersNewest fiscal year
U01DK061734Clinical Research on Nonalcoholic Fatty Liver Disease472025
P30DK120515San Diego Digestive Diseases Research Center322025
U01DK061732Continuation of the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Clinical Center-Cleveland site302025
U01DK061737Collaborative Clinical Research in Nonalcoholic Steatohepatitis302025
U01DK061738Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)302025
U01DK061713Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)262025
U01DK061728Clinical Research Network in Nonalcoholic Steatohepatitis262025
U01DK061718The Saint Louis University Component of the NASH Clinical Research Network252025
U01DK061731Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)252025
R01DK090066PNPLA3 in Susceptibility and Resistance to Fatty Liver Disease242025

1 to 10 of 1,853Source NIH's project files

See all 1,853 nih grants

Papers3,957

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
PNPLA3 Is Associated With Hepatocellular Carcinoma, While a Five-Variant Polygenic Risk Score Shows Limited Discrimination in Korean Patients With MASLD.J Gastroenterol Hepatol202642802015PubTator, text miningPubMed
Genetic Variants Associated with Response to GLP-1 Receptor Agonists in Diabetes and Obesity.Life (Basel)202642795351PubTator, text miningPubMed
An FDA‑approved dicarboxylic acid allosterically targets PNPLA3 to resolve osteoarthritis.Pharmacol Res202642790833PubTator, text miningPubMed
Ultra-rapid progression of MAFLD to cirrhosis and post-transplant steatosis in a patient with a polygenic risk profile.MedScience202642758280PubTator, text miningPubMed
Genetic Susceptibility Versus Fibrosis Progression in North Indian Metabolic Dysfunction-Associated Steatotic Liver Disease: Distinct Roles of APOC3 and PNPLA3 in a Candidate Gene Study.J Clin Exp Hepatol202642756632PubTator, text miningPubMed
Liver Fibrosis and IRS1 rs2972146 Are Associated With Weight Loss Response After Metabolic Bariatric Surgery.Diabetes Obes Metab202642755140PubTator, text miningPubMed
Risk Factors and Definition of Younger-Onset Metabolic Dysfunction-Associated Steatotic Liver Disease Cirrhosis.Clin Gastroenterol Hepatol202642749101PubTator, text miningPubMed
Ferroptosis, immune activation and MASH-related HCC.Gut202642722415PubTator, text miningPubMed
MBOAT7 rs641738 TT genotype is associated with poorer survival in MASLD-related hepatocellular carcinoma.Front Oncol202642656337PubTator, text miningPubMed
Beyond Fat: Reframing MASLD Through Genetics, Clonal Biology, and Precision Hepatology.Pharmaceuticals (Basel)202642653643PubTator, text miningPubMed

1 to 10 of 3,957

See all 3,957 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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