Gene · 8038
ADAM12: ADAM metallopeptidase domain 12
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ADAM12: ADAM metallopeptidase domain 12. Genes, record 8038. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8038
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43184 | Disintegrin and metalloproteinase domain-containing protein 12 | 909 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents63
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 36388 | O43184 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8493 | O43184 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8663 | O43184 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 239 | O43184 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 263 | O43184 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5369 | O43184 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 263 | O43184 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5369 | O43184 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8663 | O43184 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8493 | O43184 | Espacenet |
1 to 10 of 63
See all 63 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,126
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ADAM12 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| ZIAHD002400 | The Role Of Subclinical Infection And Cytokines In Preterm Parturition | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 5 | 2025 |
| P30CA014236 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 3 | 2025 |
| P30AR075043 | University of Michigan Skin Biology and Diseases Resource-based Center | 2 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 2 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 2 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 1,126Source NIH's project files
See all 1,126 nih grantsPapers1,979
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrative transcriptomics and human tibial artery validation identify ADAM12, PDK4, and RUNX1 as peripheral artery disease-associated genes enriched in calcified tibial arteries. | JVS Vasc Sci | 2026 | 42733814 | PubTator, text mining | PubMed |
Integrated single-cell and bulk transcriptomic analysis reveals an epithelial cell-derived prognostic and immunotherapeutic signature with ADAM12 as a key functional regulator in non-small cell lung cancer. | Transl Oncol | 2026 | 42705211 | PubTator, text mining | PubMed |
| Genome-Wide Association of Genetic Variants with Intestinal Cholesterol Absorption Markers in a European Population. | Nutrients | 2026 | 42654259 | PubTator, text mining | PubMed |
| Expression of ADAM10, 12, 17, and 28 Genes in Colorectal Cancer. | Int J Mol Sci | 2026 | 42653443 | PubTator, text mining | PubMed |
| Single-cell transcriptomic profiling identifies YY1 as a key regulator of fibroblast plasticity in hypertrophic scar formation. | Burns Trauma | 2026 | 42583611 | PubTator, text mining | PubMed |
| A multi-dataset single-cell meta-analysis of human keloid skin across Asian, Black and White populations reveals endothelial and mesenchymal programs linked to ethnic disparities. | Front Med (Lausanne) | 2026 | 42540716 | PubTator, text mining | PubMed |
| Integrated transcriptomic and machine learning analysis identifies female-associated candidate biomarkers in Idiopathic pulmonary arterial hypertension. | Comput Biol Chem | 2026 | 42537335 | PubTator, text mining | PubMed |
| Unveiling the dynamic transcriptomic changes in and replicative senescence balance of hUC-MSCs: A comparative study of serum-containing versus serum-free culture supplements. | Tissue Cell | 2026 | 42537251 | PubTator, text mining | PubMed |
Retraction notice to "Molecular mechanisms of recombinant proteins PTTG1IP, ADAM12, PAPSS1, and MYO1B and their effects on wound repair induced by tendon exposure: Analysis of key genes" [Int. J. Biol. Macromol. 305 (2025) 141263]. | Int J Biol Macromol | 2026 | 42481302 | PubTator, text mining | PubMed |
| Distinct Molecular Signature of Earlobe Keloids: Integrated Transcriptomic Analysis of Extracellualr Matrix, Metalloproteinase, and Metabolic Pathways. | Aesthetic Plast Surg | 2026 | 42414644 | PubTator, text mining | PubMed |
1 to 10 of 1,979
See all 1,979 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8038
GET https://conductscience.org/api/genes/v1/8038/patents?page=2