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Gene · 8038

ADAM12: ADAM metallopeptidase domain 12

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ADAM12: ADAM metallopeptidase domain 12. Genes, record 8038. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8038

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Gene

Symbol
ADAM12
HGNC
Name
ADAM metallopeptidase domain 12
HGNC
NCBI Gene ID
8038
NCBI Gene
HGNC ID
HGNC:190
HGNC
Ensembl
ENSG00000148848
NCBI Gene
Aliases
ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43184Disintegrin and metalloproteinase domain-containing protein 129090Ensembl, GeneID, HGNC

Source UniProt

Patents63

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436388O43184Espacenet
EP 4650780 A22025-11-198493O43184Espacenet
EP 4641201 A22025-10-298663O43184Espacenet
JP 2025147176 A2025-10-06239O43184Espacenet
JP 2025529142 A2025-09-04263O43184Espacenet
JP 2025529142 A2025-09-045369O43184Espacenet
US 12371689 B22025-07-29263O43184Espacenet
US 12371689 B22025-07-295369O43184Espacenet
JP 2025517969 A2025-06-128663O43184Espacenet
JP 2025517970 A2025-06-128493O43184Espacenet

1 to 10 of 63

See all 63 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,126

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleADAM12 papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition62025
P30CA008748Cancer Center Support Grant52025
P30CA010815Consolidated Basic Cancer Research Program52025
P30CA014236Cancer Center Support Grant (CCSG)32025
UL1TR001863Yale Clinical and Translational Science Award32025
P30AR075043University of Michigan Skin Biology and Diseases Resource-based Center22025
P30CA016087Cancer Center Support Grant22025
P30CA046934University of Colorado Cancer Center Support Grant22025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant22025

1 to 10 of 1,126Source NIH's project files

See all 1,126 nih grants

Papers1,979

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrative transcriptomics and human tibial artery validation identify ADAM12, PDK4, and RUNX1 as peripheral artery disease-associated genes enriched in calcified tibial arteries.JVS Vasc Sci202642733814PubTator, text miningPubMed
Integrated single-cell and bulk transcriptomic analysis reveals an epithelial cell-derived prognostic and immunotherapeutic signature with ADAM12 as a key functional regulator in non-small cell lung cancer.
Transl Oncol202642705211PubTator, text miningPubMed
Genome-Wide Association of Genetic Variants with Intestinal Cholesterol Absorption Markers in a European Population.Nutrients202642654259PubTator, text miningPubMed
Expression of ADAM10, 12, 17, and 28 Genes in Colorectal Cancer.Int J Mol Sci202642653443PubTator, text miningPubMed
Single-cell transcriptomic profiling identifies YY1 as a key regulator of fibroblast plasticity in hypertrophic scar formation.Burns Trauma202642583611PubTator, text miningPubMed
A multi-dataset single-cell meta-analysis of human keloid skin across Asian, Black and White populations reveals endothelial and mesenchymal programs linked to ethnic disparities.Front Med (Lausanne)202642540716PubTator, text miningPubMed
Integrated transcriptomic and machine learning analysis identifies female-associated candidate biomarkers in Idiopathic pulmonary arterial hypertension.Comput Biol Chem202642537335PubTator, text miningPubMed
Unveiling the dynamic transcriptomic changes in and replicative senescence balance of hUC-MSCs: A comparative study of serum-containing versus serum-free culture supplements.Tissue Cell202642537251PubTator, text miningPubMed
Retraction notice to "Molecular mechanisms of recombinant proteins PTTG1IP, ADAM12, PAPSS1, and MYO1B and their effects on wound repair induced by tendon exposure: Analysis of key genes" [Int. J. Biol. Macromol. 305 (2025) 141263].
Int J Biol Macromol202642481302PubTator, text miningPubMed
Distinct Molecular Signature of Earlobe Keloids: Integrated Transcriptomic Analysis of Extracellualr Matrix, Metalloproteinase, and Metabolic Pathways.Aesthetic Plast Surg202642414644PubTator, text miningPubMed

1 to 10 of 1,979

See all 1,979 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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