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CD276: CD276 molecule

1 protein, 382 patents, 2 drugs, 10 trials, 1,836 NIH grants and 5,896 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCD276HGNC
NameCD276 moleculeHGNC
NCBI Gene ID80381NCBI Gene
HGNC IDHGNC:19137HGNC
EnsemblENSG00000103855NCBI Gene
Aliases4Ig-B7-H3, B7-H3, B7H3, B7RP-2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q5ZPR3CD276 antigen5343Ensembl, GeneID, HGNCUniProt

Patents 382

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4828747 A12026-10-289Q5ZPR3Espacenet
EP 4831196 A22026-10-286Q5ZPR3Espacenet
WO 2026219249 A12026-10-2234Q5ZPR3Espacenet
WO 2026215363 A12026-10-1575Q5ZPR3Espacenet
WO 2026209996 A12026-10-0861Q5ZPR3Espacenet
EP 4762092 A12026-06-2433Q5ZPR3Espacenet
EP 4750803 A12026-06-03131Q5ZPR3Espacenet
JP 2026515434 A2026-05-1871Q5ZPR3Espacenet
US 12624087 B22026-05-126Q5ZPR3Espacenet
JP 2026513925 A2026-05-0116Q5ZPR3Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
8H9 131ICHEMBL2109310CD276 antigen binding agentBINDING AGENTChEMBL
ENOBLITUZUMABCHEMBL3545373CD276 antigen cross-linking agentCROSS-LINKING AGENTChEMBL

Trials 10

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06014255ENOBLITUZUMABPHASE2ClinicalTrials.gov
NCT05708924ENOBLITUZUMABPHASE12025-08-14ClinicalTrials.gov
NCT04634825ENOBLITUZUMABPHASE22023-12-20ClinicalTrials.gov
NCT04630769ENOBLITUZUMABPHASE12023-04-03ClinicalTrials.gov
NCT04129320ENOBLITUZUMABPHASE2/PHASE3ClinicalTrials.gov
NCT02982941ENOBLITUZUMABPHASE1ClinicalTrials.gov
NCT02923180ENOBLITUZUMABPHASE22021-08-24ClinicalTrials.gov
NCT02475213ENOBLITUZUMABPHASE12025-08-11ClinicalTrials.gov
NCT02381314ENOBLITUZUMABPHASE1ClinicalTrials.gov
NCT01391143ENOBLITUZUMABPHASE1ClinicalTrials.gov

NIH grants 1836

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant642,025NIH's project files
P30CA016672Cancer Center Support Grant332,025NIH's project files
P30CA006973Regional Oncology Research Center172,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)152,025NIH's project files
P30CA016359Cancer Center Support Grant122,025NIH's project files
R01CA175495The B7x pathways in the tumor microenvironment122,025NIH's project files
P30CA016086Cancer Center Support Grant112,025NIH's project files
P30CA124435Stanford Cancer Institute112,025NIH's project files
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)112,025NIH's project files
P01CA217959Discovering and Exploiting Mechanisms of Neuroblastoma Therapy Resistance102,025NIH's project files

Papers 5896

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823155PubTator, text miningPubMed
42819422PubTator, text miningPubMed
42818194PubTator, text miningPubMed
42816994PubTator, text miningPubMed
42816201PubTator, text miningPubMed
42814277PubTator, text miningPubMed
42812529PubTator, text miningPubMed
42811483PubTator, text miningPubMed
42801642PubTator, text miningPubMed
42777908PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license