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Gene · 8065

CUL5: cullin 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CUL5: cullin 5. Genes, record 8065. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8065

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Gene

Symbol
CUL5
HGNC
Name
cullin 5
HGNC
NCBI Gene ID
8065
NCBI Gene
HGNC ID
HGNC:2556
HGNC
Ensembl
ENSG00000166266
NCBI Gene
Aliases
CUL-5, VACM-1, VACM1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q93034Cullin-578015Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1442560Q93034Espacenet
JP 2026004568 A2026-01-1442561Q93034Espacenet
WO 2025239292 A2025-11-201Q93034Espacenet
EP 4650780 A22025-11-1910991Q93034Espacenet
EP 4641201 A22025-10-2911403Q93034Espacenet
JP 2025517969 A2025-06-1211403Q93034Espacenet
JP 2025517970 A2025-06-1210991Q93034Espacenet
EP 4253412 A22023-10-0416Q93034Espacenet
US 11492404 B22022-11-0816Q93034Espacenet
US 11446398 B22022-09-2020798Q93034Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,232

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCUL5 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)172025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control112025
P30AI027763UCSF-Bay Area Center for AIDS Research82025
T32AI083196Minnesota Training Program in Virology62025
ZIAAI000669Molecular Analysis Of Retroviral Genes And Their Products62025
P30CA015704Cancer Center Support Grant52025
R01GM122768The mechanisms regulating actin dynamics and polarized membrane transport during cell migration52025
T32AI060537Integrative Microbiology Program52025
ZIABC010595Structure and Function of Vif and APOBEC3 (A3) Proteins52025
U19AI135990HPMI: Host Pathogen Mapping Initiative42025

1 to 10 of 1,232Source NIH's project files

See all 1,232 nih grants

Papers1,704

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Inhibition of nucleoporin 214 depletes leukemia stem cells by promoting heme catabolism and lipid peroxidation.Blood202642640860PubTator, text miningPubMed
Neddylation-dependent RAB40-Cullin5 E3 ligase complex controls ubiquitin-mediated proteasomal degradation of DNAJC13.BBA Adv202642602476PubTator, text miningPubMed
Discovery of spirocyclic amide scaffolds as novel neddylation E1 inhibitors to suppress the growth and survival of lung cancer cells.RSC Med Chem202642559520PubTator, text miningPubMed
A de novo designed enzyme for photo-proximity labeling of E3 ligase neighborhoods in live cells.bioRxiv202642538903PubTator, text miningPubMed
Structure of the E3 ligase CRL2ZYG11B with substrates reveals the molecular basis for N-degron recognition and ubiquitination.Cell Rep202642224082PubTator, text miningPubMed
Targeting UBE2F induces a resilience program enhancing CD8 T cell immunity.J Exp Med202642188874PubTator, text miningPubMed
Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1.Nat Commun202642098103PubTator, text miningPubMed
ASB7 promotes osteosarcoma lung metastasis through ubiquitin-mediated degradation of ATF2.Cell Discov202642086529PubTator, text miningPubMed
CUL5-mediated ubiquitination in cancer cell therapy: context-dependent roles, molecular networks, and emerging therapeutic avenues.Front Med (Lausanne)202642078440PubTator, text miningPubMed
In silico analysis of gene expression signatures and drug repurposing associated with metastatic progression in melanoma (skin cancer).Naunyn Schmiedebergs Arch Pharmacol202642068380PubTator, text miningPubMed

1 to 10 of 1,704

See all 1,704 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8065

GET https://conductscience.org/api/genes/v1/8065/patents?page=2