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FGF23: fibroblast growth factor 23

1 protein, 395 patents, 1 drug, 24 trials, 2,896 NIH grants and 10,452 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFGF23HGNC
Namefibroblast growth factor 23HGNC
NCBI Gene ID8074NCBI Gene
HGNC IDHGNC:3680HGNC
EnsemblENSG00000118972NCBI Gene
AliasesADHR, FGFN, HFTC2, HPDR2, HYPF, PHPTCNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9GZV9Fibroblast growth factor 232516Ensembl, GeneID, HGNCUniProt

Patents 395

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11560Q9GZV9Espacenet
EP 4676955 A22026-01-1417Q9GZV9Espacenet
EP 4650780 A22025-11-19950Q9GZV9Espacenet
EP 4647444 A22025-11-1212Q9GZV9Espacenet
KR 1020250157441 A2025-11-0417Q9GZV9Espacenet
EP 4641201 A22025-10-29667Q9GZV9Espacenet
JP 2025147176 A2025-10-065281Q9GZV9Espacenet
JP 2025529142 A2025-09-046374Q9GZV9Espacenet
US 12371689 B22025-07-296374Q9GZV9Espacenet
US 12358976 B22025-07-1512Q9GZV9Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BUROSUMABCHEMBL3707326Fibroblast growth factor 23 inhibitorINHIBITORChEMBL

Trials 24

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06202027BUROSUMABClinicalTrials.gov
NCT05509595BUROSUMABPHASE22026-02-02ClinicalTrials.gov
NCT05181839BUROSUMABClinicalTrials.gov
NCT04695860BUROSUMABPHASE3ClinicalTrials.gov
NCT04419363BUROSUMABPHASE4ClinicalTrials.gov
NCT04308096BUROSUMABPHASE3ClinicalTrials.gov
NCT04188964BUROSUMABPHASE1/PHASE2ClinicalTrials.gov
NCT04159675BUROSUMABClinicalTrials.gov
NCT04146935BUROSUMABPHASE42023-08-24ClinicalTrials.gov
NCT03920072BUROSUMABPHASE3ClinicalTrials.gov

NIH grants 2896

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
U01DK060963Tulane Clinical Center for Chronic Renal Insufficiency Cohort Study582,025NIH's project files
U01DK060902Chronic Renal Insufficiency Cohort (CRIC) Study Clinical Center572,025NIH's project files
U01DK060980Continuation of the University of Illinois Chicago CRIC Clinical Center552,025NIH's project files
U01DK060984Prospective renal insufficiency cohort evaluation: PRICE552,025NIH's project files
U01DK061021Chronic Renal Insufficiency Cohort Limited competition continuation542,025NIH's project files
U01DK061028Chronic Renal Insufficiency Cohort (CRIC) Study542,025NIH's project files
ZIADE000649Skeletal Disorders and Mineral Homeostasis Section522,025NIH's project files
U01DK061022Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Hopkins Clinical Center452,025NIH's project files
P20GM109036Tulane COBRE for Clinical and Translational Research in Cardiometabolic Diseases322,025NIH's project files
P30DK035816Nutrition Obesity Research Center302,025NIH's project files

Papers 10452

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826311PubTator, text miningPubMed
42822723PubTator, text miningPubMed
42820547PubTator, text miningPubMed
42819971PubTator, text miningPubMed
42809342PubTator, text miningPubMed
42802776PubTator, text miningPubMed
42802058PubTator, text miningPubMed
42793194PubTator, text miningPubMed
42793073PubTator, text miningPubMed
42786596PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license