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COL18A1: collagen type XVIII alpha 1 chain

1 protein, 69 patents, 2 drugs, 66 trials, 2,814 NIH grants and 5,803 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCOL18A1HGNC
Namecollagen type XVIII alpha 1 chainHGNC
NCBI Gene ID80781NCBI Gene
HGNC IDHGNC:2195HGNC
EnsemblENSG00000182871NCBI Gene
AliasesGLCC, KNO, KNO1, KSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P39060Collagen alpha-1(XVIII) chain1,7549Ensembl, GeneID, HGNCUniProt

Patents 69

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11208P39060Espacenet
WO 2025262023 A12025-12-2624P39060Espacenet
WO 2025262025 A12025-12-2624P39060Espacenet
WO 2025262082 A12025-12-2624P39060Espacenet
EP 4650780 A22025-11-197707P39060Espacenet
EP 4641201 A22025-10-297753P39060Espacenet
EP 4641203 A22025-10-29220P39060Espacenet
JP 2025147176 A2025-10-063249P39060Espacenet
JP 2025529142 A2025-09-045939P39060Espacenet
US 12371689 B22025-07-295939P39060Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
COLLAGENASE CLOSTRIDIUM HISTOLYTICUMCHEMBL2108709Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL
OCRIPLASMINCHEMBL2095222Collagen hydrolytic enzymeHYDROLYTIC ENZYMEChEMBL

Trials 66

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06169319COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT06151197COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT06065436COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05646602COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT05254457COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT05152173COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE2ClinicalTrials.gov
NCT04874870COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE3ClinicalTrials.gov
NCT04680156COLLAGENASE CLOSTRIDIUM HISTOLYTICUMClinicalTrials.gov
NCT04496167COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22023-09-13ClinicalTrials.gov
NCT04236635COLLAGENASE CLOSTRIDIUM HISTOLYTICUMPHASE22022-04-12ClinicalTrials.gov

NIH grants 2814

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30EY001792P30 Core Grant for Vision Research182,025NIH's project files
P30CA016672Cancer Center Support Grant172,025NIH's project files
K24AR060297Scleroderma Twin Study and analysis of Estrogen in patients with dcSSc82,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant72,025NIH's project files
P30EY016665Core Grant for Vision Research72,025NIH's project files
P30CA013696Cancer Center Support Grant52,025NIH's project files
P30CA008748Cancer Center Support Grant42,025NIH's project files
P30CA047904Cancer Center Support Grant42,025NIH's project files
P30CA068485Cancer Center Support Grant42,025NIH's project files
R01EY024698Gene Editing and Silencing in Phototransduction42,025NIH's project files

Papers 5803

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42787631PubTator, text miningPubMed
42754619PubTator, text miningPubMed
42753640PubTator, text miningPubMed
42747227PubTator, text miningPubMed
42710781PubTator, text miningPubMed
42681150PubTator, text miningPubMed
42675719PubTator, text miningPubMed
42656915PubTator, text miningPubMed
42650354PubTator, text miningPubMed
42648285PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license