Gene · 81
ACTN4: actinin alpha 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ACTN4: actinin alpha 4. Genes, record 81. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/81
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O43707 | Alpha-actinin-4 | 911 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents94
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 1406 | O43707 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1038 | O43707 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1038 | O43707 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1406 | O43707 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 1538 | O43707 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 1546 | O43707 | Espacenet |
| JP 2025038035 A | 2025-03-18 | 4377 | O43707 | Espacenet |
| EP 4487869 A2 | 2025-01-08 | 9 | O43707 | Espacenet |
| EP 4463571 A1 | 2024-11-20 | 183 | O43707 | Espacenet |
| US 12134655 B2 | 2024-11-05 | 4377 | O43707 | Espacenet |
1 to 10 of 94
See all 94 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,537
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ACTN4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 5 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 4 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 4 | 2025 |
| P30DK020579 | Diabetes Research Center | 4 | 2025 |
| R01GM066817 | The Biochemical Basis for the Mechanics of Cytokinesis | 4 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA043703 | Case Comprehensive Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,537Source NIH's project files
See all 1,537 nih grantsPapers2,438
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Reveal the diagnostic value of a neutrophil inflammation- and cell death-associated gene signature in rheumatoid arthritis. | Medicine (Baltimore) | 2026 | 42760665 | PubTator, text mining | PubMed |
| Integrative Analysis of Gene and Protein Expression Data Reveals Novel Clusters for Ovarian Cancer Prognosis. | Int J Mol Sci | 2026 | 42653150 | PubTator, text mining | PubMed |
| SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation. | Proc Natl Acad Sci U S A | 2026 | 42636358 | PubTator, text mining | PubMed |
| Prognostic characteristics of disulfidptosis-related genes across cancers and their potential implications in osteosarcoma. | Sci Prog | 2026 | 42370567 | PubTator, text mining | PubMed |
| Screening and Validation of LTBP1 as a Key Target of Oxymatrine in Inhibiting Cardiac Fibroblast Differentiation Under High Glucose Conditions: In Vitro and Bioinformatic Studies. | Int J Mol Sci | 2026 | 42074126 | PubTator, text mining | PubMed |
| Chaperonin in health and disease. | Mol Biomed | 2026 | 41920440 | PubTator, text mining | PubMed |
| Recurrence of focal segmental glomerulosclerosis: An updated review of pathophysiology, biomarkers, and therapeutic strategies. | Cell Transplant | 2026 | 41906863 | PubTator, text mining | PubMed |
| Programmed cell death: a promising management for Alzheimer's disease. | Apoptosis | 2026 | 41904723 | PubTator, text mining | PubMed |
| Linking first-pass reperfusion success to proteomic markers in large and medium vessel ischemic stroke: an exploratory study. | Precis Clin Med | 2026 | 41878235 | PubTator, text mining | PubMed |
| Force-modulated structural landscape of the catch bonding F-actin crosslinker α-actinin-4. | bioRxiv | 2026 | 41867833 | PubTator, text mining | PubMed |
1 to 10 of 2,438
See all 2,438 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/81
GET https://conductscience.org/api/genes/v1/81/patents?page=2