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Gene · 81

ACTN4: actinin alpha 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACTN4: actinin alpha 4. Genes, record 81. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/81

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Gene

Symbol
ACTN4
HGNC
Name
actinin alpha 4
HGNC
NCBI Gene ID
81
NCBI Gene
HGNC ID
HGNC:166
HGNC
Ensembl
ENSG00000130402
NCBI Gene
Aliases
ACTININ-4, FSGS, FSGS1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43707Alpha-actinin-49115Ensembl, GeneID, HGNC

Source UniProt

Patents94

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191406O43707Espacenet
EP 4641201 A22025-10-291038O43707Espacenet
JP 2025517969 A2025-06-121038O43707Espacenet
JP 2025517970 A2025-06-121406O43707Espacenet
JP 2025062604 A2025-04-141538O43707Espacenet
JP 2025062604 A2025-04-141546O43707Espacenet
JP 2025038035 A2025-03-184377O43707Espacenet
EP 4487869 A22025-01-089O43707Espacenet
EP 4463571 A12024-11-20183O43707Espacenet
US 12134655 B22024-11-054377O43707Espacenet

1 to 10 of 94

See all 94 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,537

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACTN4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
P30CA008748Cancer Center Support Grant72025
P30DK058404Molecular and Cellular Basis for Digestive Diseases52025
P30CA010815Consolidated Basic Cancer Research Program42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
P30DK020579Diabetes Research Center42025
R01GM066817The Biochemical Basis for the Mechanics of Cytokinesis42025
P30CA006973Regional Oncology Research Center32025
P30CA021765Cancer Center Support Grant (CCSG)32025
P30CA043703Case Comprehensive Cancer Center Support Grant32025

1 to 10 of 1,537Source NIH's project files

See all 1,537 nih grants

Papers2,438

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Reveal the diagnostic value of a neutrophil inflammation- and cell death-associated gene signature in rheumatoid arthritis.Medicine (Baltimore)202642760665PubTator, text miningPubMed
Integrative Analysis of Gene and Protein Expression Data Reveals Novel Clusters for Ovarian Cancer Prognosis.Int J Mol Sci202642653150PubTator, text miningPubMed
SIRT2 deacylase modulators control B cell metabolic reprogramming in EBV infection and mitogenic activation.Proc Natl Acad Sci U S A202642636358PubTator, text miningPubMed
Prognostic characteristics of disulfidptosis-related genes across cancers and their potential implications in osteosarcoma.Sci Prog202642370567PubTator, text miningPubMed
Screening and Validation of LTBP1 as a Key Target of Oxymatrine in Inhibiting Cardiac Fibroblast Differentiation Under High Glucose Conditions: In Vitro and Bioinformatic Studies.Int J Mol Sci202642074126PubTator, text miningPubMed
Chaperonin in health and disease.Mol Biomed202641920440PubTator, text miningPubMed
Recurrence of focal segmental glomerulosclerosis: An updated review of pathophysiology, biomarkers, and therapeutic strategies.Cell Transplant202641906863PubTator, text miningPubMed
Programmed cell death: a promising management for Alzheimer's disease.Apoptosis202641904723PubTator, text miningPubMed
Linking first-pass reperfusion success to proteomic markers in large and medium vessel ischemic stroke: an exploratory study.Precis Clin Med202641878235PubTator, text miningPubMed
Force-modulated structural landscape of the catch bonding F-actin crosslinker α-actinin-4.bioRxiv202641867833PubTator, text miningPubMed

1 to 10 of 2,438

See all 2,438 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/81

GET https://conductscience.org/api/genes/v1/81/patents?page=2