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Gene · 81027

TUBB1: tubulin beta 1 class VI

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TUBB1: tubulin beta 1 class VI. Genes, record 81027. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/81027

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Gene

Symbol
TUBB1
HGNC
Name
tubulin beta 1 class VI
HGNC
NCBI Gene ID
81027
NCBI Gene
HGNC ID
HGNC:16257
HGNC
Ensembl
ENSG00000101162
NCBI Gene
Aliases
MACTHC1, dJ543J19.4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H4B7Tubulin beta-1 chain4510Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468524Q9H4B7Espacenet
US 11446398 B22022-09-2093576Q9H4B7Espacenet
JP 2022524081 A2022-04-27196547Q9H4B7Espacenet
US 11078247 B22021-08-0312150Q9H4B7Espacenet
WO 2019229113 A12019-12-052Q9H4B7Espacenet
JP 2019054813 A2019-04-11248959Q9H4B7Espacenet
JP 2017121241 A2017-07-13248959Q9H4B7Espacenet
JP 2016507723 A2016-03-10179Q9H4B7Espacenet
EP 2926138 A22015-10-07179Q9H4B7Espacenet
KR 1020150090240 A2015-08-05179Q9H4B7Espacenet

1 to 10 of 23

See all 23 patents

Drugs91

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABT-751CHEMBL20684Tubulin beta inhibitorINHIBITORChEMBL
AGS-16C3FCHEMBL4594455Tubulin disrupting agentDISRUPTING AGENTChEMBL
ANETUMAB RAVTANSINECHEMBL2109629Tubulin inhibitorINHIBITORChEMBL
ANG1005CHEMBL1089636Tubulin inhibitorINHIBITORChEMBL
ANVATABART OPADOTINCHEMBL4297892Tubulin inhibitorINHIBITORChEMBL
APRUTUMAB IXADOTINCHEMBL4650293Tubulin inhibitorINHIBITORChEMBL
ASG-5MECHEMBL2109574Tubulin inhibitorINHIBITORChEMBL
AVE-9633CHEMBL2109266Tubulin inhibitorINHIBITORChEMBL
AZINTUXIZUMAB VEDOTINCHEMBL4297859Tubulin inhibitorINHIBITORChEMBL
BELANTAMAB MAFODOTINCHEMBL4298209Tubulin inhibitorINHIBITORChEMBL

1 to 10 of 91

See all 91 drugs

Trials8,740

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07604766PACLITAXELPHASE3ClinicalTrials.gov
NCT07602907PACLITAXELPHASE2ClinicalTrials.gov
NCT07601737PACLITAXELPHASE2ClinicalTrials.gov
NCT07601178PACLITAXELPHASE2ClinicalTrials.gov
NCT07599163PACLITAXELClinicalTrials.gov
NCT07595770PACLITAXELPHASE2ClinicalTrials.gov
NCT07594548PACLITAXELPHASE1ClinicalTrials.gov
NCT07591467DOCETAXELPHASE3ClinicalTrials.gov
NCT07589972VINORELBINEClinicalTrials.gov
NCT07588698VINCRISTINE SULFATEPHASE2ClinicalTrials.gov

1 to 10 of 8,740

See all 8,740 trials

NIH grants474

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTUBB1 papersNewest fiscal year
ZIAHL006170Cardiovascular Genomics and Bioinformatics projects32025
P30CA008748Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
R01CA240981Harnessing E3 Ligases for Cancer Therapy22025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal22025
ZIAHD008765Microtubule regulation by isotype expression, post translational modification, and by small molecules.22025
I01CX001696Platelet Reprogramming During Inflammation12025
I01CX002422Investigate the mechanism of autoreactive B cell-mediated immunological failure despite virologic suppression in HIV-infected individuals on antiretroviral therapy12025
K12HD000850Pediatric Scientist Development Program12025
KL2TR002379Institutional Career Development Core12025

1 to 10 of 474Source NIH's project files

See all 474 nih grants

Papers625

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Effects of Mebendazole and Flutamide Combination in Prostate Cancer Cell Lines: a Comprehensive in Vitro Analysis.Cell Physiol Biochem202642675957PubTator, text miningPubMed
Clonal lineage tracing of innate immune cells in human cancer.Cancer Cell202642242233PubTator, text miningPubMed
A Novel TUBB1 p.E158del Variant Causes Inherited Macrothrombocytopenia via Impaired Microtubule Assembly.Int J Lab Hematol202642191667PubTator, text miningPubMed
Architects of the Developing Brain: Cytoskeleton-Organizing Molecules in Neurodevelopmental Disorders.Cells202641892327PubTator, text miningPubMed
Co-inheritance of ITGA2B and TUBB1 variants in a family reveals distinct genetic contributions to platelet dysfunction.Br J Haematol202641881807PubTator, text miningPubMed
B cells and humoral immunity in melanoma: regulatory and autoimmune-like features and implications for immunotherapy.Oncoimmunology202641792971PubTator, text miningPubMed
TCL1A mediates DNA methylation defects in recurrent hydatidiform mole with NLRP7 pathogenic variants.Nat Commun202641786744PubTator, text miningPubMed
Differentially expressed proteins in plasma-derived extracellular vesicles from chronic myeloid leukemia patients.Front Genet202641773228PubTator, text miningPubMed
A molecular and spatial resource defining tubulin isotype organization during corneal development.bioRxiv202641756856PubTator, text miningPubMed
Clinical parameters and emerging biomarkers of partial remission in pediatric type 1 diabetes: a systematic review.Front Endocrinol (Lausanne)202641737050PubTator, text miningPubMed

1 to 10 of 625

See all 625 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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