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Gene · 81607

NECTIN4: nectin cell adhesion molecule 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NECTIN4: nectin cell adhesion molecule 4. Genes, record 81607. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/81607

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Gene

Symbol
NECTIN4
HGNC
Name
nectin cell adhesion molecule 4
HGNC
NCBI Gene ID
81607
NCBI Gene
HGNC ID
HGNC:19688
HGNC
Ensembl
ENSG00000143217
NCBI Gene
Aliases
EDSS1, LNIR, PRR4, PVRL4, nectin-4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96NY8Nectin-45105Ensembl, GeneID, HGNC

Source UniProt

Patents249

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4808978 A12026-09-2325Q96NY8Espacenet
EP 4780498 A12026-07-292Q96NY8Espacenet
EP 4731673 A12026-04-291Q96NY8Espacenet
EP 4725964 A12026-04-1531Q96NY8Espacenet
JP 2026048848 A2026-03-172Q96NY8Espacenet
JP 2026004568 A2026-01-1458301Q96NY8Espacenet
JP 2025539087 A2025-12-0371Q96NY8Espacenet
JP 2025539087 A2025-12-0372Q96NY8Espacenet
EP 4650780 A22025-11-198346Q96NY8Espacenet
JP 2025170007 A2025-11-142Q96NY8Espacenet

1 to 10 of 249

See all 249 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
ENFORTUMAB VEDOTINCHEMBL3301589Nectin-4 binding agentBINDING AGENT

Source ChEMBL

Trials48

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07566156ENFORTUMAB VEDOTINPHASE3ClinicalTrials.gov
NCT07374549ENFORTUMAB VEDOTINPHASE2ClinicalTrials.gov
NCT07347314ENFORTUMAB VEDOTINPHASE2ClinicalTrials.gov
NCT07346053ENFORTUMAB VEDOTINPHASE3ClinicalTrials.gov
NCT07287995ENFORTUMAB VEDOTINPHASE1/PHASE2ClinicalTrials.gov
NCT07232602ENFORTUMAB VEDOTINPHASE1/PHASE2ClinicalTrials.gov
NCT07221942ENFORTUMAB VEDOTINPHASE2ClinicalTrials.gov
NCT07218380ENFORTUMAB VEDOTINPHASE3ClinicalTrials.gov
NCT07217496ENFORTUMAB VEDOTINPHASE1ClinicalTrials.gov
NCT07183319ENFORTUMAB VEDOTINPHASE2ClinicalTrials.gov

1 to 10 of 48

See all 48 trials

NIH grants580

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNECTIN4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant292025
P50CA136393Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancer122025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant112025
P30CA016672Cancer Center Support Grant92025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes52025
P30CA014520UW Comprehensive Cancer Center Support42025
P30DK054759Precision Medicine Center for Cystic Fibrosis42025
P50CA116201Mayo Clinic Breast Cancer SPORE42025
K12CA184746MSK Paul Calabresi Career Development Award for Clinical Oncology32025
P30CA013696Cancer Center Support Grant32025

1 to 10 of 580Source NIH's project files

See all 580 nih grants

Papers1,879

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Nectin-4-Directed Therapeutic Repositioning Augments Antitumor Efficacy in Epithelial Ovarian Carcinoma.Cancer Commun (Lond)202642819105PubTator, text miningPubMed
Nectin-4-Targeted PET/CT Before Organ-Sacrificing Surgery for Occult Ureteral Carcinoma.J Nucl Med202642816126PubTator, text miningPubMed
Nectin4 as a Promising Target for CAR-NK Cell Therapy in Breast Cancer Treatment.Front Biosci (Landmark Ed)202642811988PubTator, text miningPubMed
Time to Rethink Pathology Reporting in Adenoid Cystic Carcinoma.Head Neck202642811719PubTator, text miningPubMed
Pretreatment Tumor NECTIN4 RNA Expression Is Associated with First-line Enfortumab Vedotin Plus Pembrolizumab Efficacy in Metastatic Urothelial Cancer.Eur Urol202642786066PubTator, text miningPubMed
NECTIN4, TROP2 and PDL1 in Breast Cancer: Immunohistochemical Profiling and Clinical Associations.Int J Surg Pathol202642770457PubTator, text miningPubMed
Beyond approval: a mechanism-based review of novel anti-tumour agents in cervical cancer and when to use them.Front Immunol202642769609PubTator, text miningPubMed
Enfortumab vedotin-related cutaneous toxicity: Clinical features, pathogenesis and management.J Dermatol Sci202642754439PubTator, text miningPubMed
Immunohistochemical stratification of bladder small cell carcinoma reveals two major phenotypes with distinct therapeutic biomarker profiles.Histopathology202642747234PubTator, text miningPubMed
Expression of nectin-4 in squamous cell carcinoma of prostate: a pilot study and case report.Front Oncol202642740991PubTator, text miningPubMed

1 to 10 of 1,879

See all 1,879 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/81607

GET https://conductscience.org/api/genes/v1/81607/patents?page=2