Gene · 81620
CDT1: chromatin licensing and DNA replication factor 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CDT1: chromatin licensing and DNA replication factor 1. Genes, record 81620. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/81620
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9H211 | DNA replication factor Cdt1 | 546 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents13
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 41306 | Q9H211 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 4037 | Q9H211 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4769 | Q9H211 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 4037 | Q9H211 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4769 | Q9H211 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 15196 | Q9H211 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 118167 | Q9H211 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 1971 | Q9H211 | Espacenet |
| JP 2020062004 A | 2020-04-23 | 1319 | Q9H211 | Espacenet |
| WO 2020059708 A | 2020-03-26 | 50 | Q9H211 | Espacenet |
1 to 10 of 13
See all 13 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,746
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CDT1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016086 | Cancer Center Support Grant | 15 | 2025 |
| R01GM045436 | Initiation of DNA Replication at Cell Origins in Yeast | 14 | 2025 |
| ZIABC010411 | Initiation of DNA Replication in Mammalian Cells | 12 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 11 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 11 | 2025 |
| P01CA013106 | Targeting Transcription and Splicing in Cancer | 9 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 9 | 2025 |
| P30CA014051 | Cancer Center Support (Core) Grant | 8 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 8 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 8 | 2025 |
1 to 10 of 1,746Source NIH's project files
See all 1,746 nih grantsPapers2,556
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The chromosomal instability associated gene C2orf76 exerts dual roles in colorectal cancer through pyroptosis and chemotherapy response. | Front Oncol | 2026 | 42656254 | PubTator, text mining | PubMed |
Integrating single-cell analysis and machine learning algorithms to explore lactylation-related molecular mechanisms and therapeutic responses in clear cell renal cell carcinoma and identifying CDT1 as a potential biomarker. | Front Endocrinol (Lausanne) | 2026 | 42625671 | PubTator, text mining | PubMed |
| CDT1 acts with the replisome to remodel replication forks. | Sci Adv | 2026 | 42585314 | PubTator, text mining | PubMed |
| CDK12 mediates the inhibition effect of mechanical unloading on osteoblast proliferation by regulating RNAPII transcription activation. | Bone Joint Res | 2026 | 42486479 | PubTator, text mining | PubMed |
| SauCas9-based cell cycle-dependent genome editing via AAV delivery. | Mol Ther Adv | 2026 | 42211740 | PubTator, text mining | PubMed |
| CDT1 and E2F1 synergistically promote the glycolysis and progression of non-small cell lung cancer through the TPX2/AKT pathway. | Eur J Pharmacol | 2026 | 42035943 | PubTator, text mining | PubMed |
| Predicting DNA replication-related protein expression at the nucleus level from HE: A deep learning study with same-specimen paired data. | Acta Histochem | 2026 | 42035593 | PubTator, text mining | PubMed |
| Large-scale APP duplication in early-onset Alzheimer's disease without cerebral amyloid angiopathy: A case report. | J Alzheimers Dis Rep | 2026 | 41929947 | PubTator, text mining | PubMed |
| Multi-omics identification of a programmed cell death-related signature and potential target P4HB for bladder cancer based on a 101-combination machine learning and experimental validation. | Clin Exp Med | 2026 | 41925913 | PubTator, text mining | PubMed |
| An updated view on lagging strand DNA replication: implications for the replication stress response. | Cell Cycle | 2026 | 41865289 | PubTator, text mining | PubMed |
1 to 10 of 2,556
See all 2,556 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/81620
GET https://conductscience.org/api/genes/v1/81620/patents