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Gene · 81620

CDT1: chromatin licensing and DNA replication factor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CDT1: chromatin licensing and DNA replication factor 1. Genes, record 81620. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/81620

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Gene

Symbol
CDT1
HGNC
Name
chromatin licensing and DNA replication factor 1
HGNC
NCBI Gene ID
81620
NCBI Gene
HGNC ID
HGNC:24576
HGNC
Ensembl
ENSG00000167513
NCBI Gene
Aliases
DUP, RIS2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9H211DNA replication factor Cdt15466Ensembl, GeneID, HGNC

Source UniProt

Patents13

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441306Q9H211Espacenet
EP 4650780 A22025-11-194037Q9H211Espacenet
EP 4641202 A22025-10-294769Q9H211Espacenet
JP 2025517970 A2025-06-124037Q9H211Espacenet
KR 1020250017231 A2025-02-044769Q9H211Espacenet
US 11446398 B22022-09-2015196Q9H211Espacenet
JP 2022524081 A2022-04-27118167Q9H211Espacenet
US 11078247 B22021-08-031971Q9H211Espacenet
JP 2020062004 A2020-04-231319Q9H211Espacenet
WO 2020059708 A2020-03-2650Q9H211Espacenet

1 to 10 of 13

See all 13 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,746

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCDT1 papersNewest fiscal year
P30CA016086Cancer Center Support Grant152025
R01GM045436Initiation of DNA Replication at Cell Origins in Yeast142025
ZIABC010411Initiation of DNA Replication in Mammalian Cells122025
P30CA008748Cancer Center Support Grant112025
P30CA016672Cancer Center Support Grant112025
P01CA013106Targeting Transcription and Splicing in Cancer92025
P30CA044579University of Virginia Cancer Center Support Grant92025
P30CA014051Cancer Center Support (Core) Grant82025
P30CA016087Cancer Center Support Grant82025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control82025

1 to 10 of 1,746Source NIH's project files

See all 1,746 nih grants

Papers2,556

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The chromosomal instability associated gene C2orf76 exerts dual roles in colorectal cancer through pyroptosis and chemotherapy response.Front Oncol202642656254PubTator, text miningPubMed
Integrating single-cell analysis and machine learning algorithms to explore lactylation-related molecular mechanisms and therapeutic responses in clear cell renal cell carcinoma and identifying CDT1 as a potential biomarker.
Front Endocrinol (Lausanne)202642625671PubTator, text miningPubMed
CDT1 acts with the replisome to remodel replication forks.Sci Adv202642585314PubTator, text miningPubMed
CDK12 mediates the inhibition effect of mechanical unloading on osteoblast proliferation by regulating RNAPII transcription activation.Bone Joint Res202642486479PubTator, text miningPubMed
SauCas9-based cell cycle-dependent genome editing via AAV delivery.Mol Ther Adv202642211740PubTator, text miningPubMed
CDT1 and E2F1 synergistically promote the glycolysis and progression of non-small cell lung cancer through the TPX2/AKT pathway.Eur J Pharmacol202642035943PubTator, text miningPubMed
Predicting DNA replication-related protein expression at the nucleus level from HE: A deep learning study with same-specimen paired data.Acta Histochem202642035593PubTator, text miningPubMed
Large-scale APP duplication in early-onset Alzheimer's disease without cerebral amyloid angiopathy: A case report.J Alzheimers Dis Rep202641929947PubTator, text miningPubMed
Multi-omics identification of a programmed cell death-related signature and potential target P4HB for bladder cancer based on a 101-combination machine learning and experimental validation.Clin Exp Med202641925913PubTator, text miningPubMed
An updated view on lagging strand DNA replication: implications for the replication stress response.Cell Cycle202641865289PubTator, text miningPubMed

1 to 10 of 2,556

See all 2,556 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/81620

GET https://conductscience.org/api/genes/v1/81620/patents