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Gene · 8165

AKAP1: A-kinase anchoring protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. AKAP1: A-kinase anchoring protein 1. Genes, record 8165. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8165

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Gene

Symbol
AKAP1
HGNC
Name
A-kinase anchoring protein 1
HGNC
NCBI Gene ID
8165
NCBI Gene
HGNC ID
HGNC:367
HGNC
Ensembl
ENSG00000121057
NCBI Gene
Aliases
AKAP, AKAP121, AKAP149, AKAP84, D-AKAP1, PPP1R43, PRKA1, S-AKAP84, SAKAP84, TDRD17
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92667A-kinase anchor protein 1, mitochondrial9030Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1435869Q92667Espacenet
JP 2026004568 A2026-01-1435871Q92667Espacenet
EP 4650780 A22025-11-196305Q92667Espacenet
JP 2025529142 A2025-09-04356Q92667Espacenet
US 12371689 B22025-07-29356Q92667Espacenet
JP 2025517970 A2025-06-126305Q92667Espacenet
JP 2025062604 A2025-04-14585Q92667Espacenet
JP 2025062604 A2025-04-14587Q92667Espacenet
JP 2025062604 A2025-04-14594Q92667Espacenet
JP 2025062604 A2025-04-14595Q92667Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,333

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAKAP1 papersNewest fiscal year
R01DK073368Mechanisms of Compartmentalized cAMP Signaling172025
R01DK119192Defective PKA Signaling in Cushing's Syndrome102025
R35CA197622Live-cell Activity Architecture in Cancer92025
T32CA009523Contemporary Approaches to Cancer Cell Signaling and Communication72025
T32DK007247Diabetes, Obesity and Metabolism Training Program42025
P20GM130459Nevada Center of Biomedical Research Excellence in Molecular and Cellular Signal Transduction in the Cardiovascular System32025
P30CA023108Cancer Center Support Grant32025
P30CA091842Cancer Center Support Grant32025
R01DK080834Inhibition of an Apical cAMP/cGMP Transporter (MRP4) in the Gut Induces Diarrhea32025
R01HL058506G Protein-Coupled Receptor Regulation in Airway Myocytes32025

1 to 10 of 1,333Source NIH's project files

See all 1,333 nih grants

Papers1,448

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Corrigendum to "AKAP1 orchestrates mitochondrial dynamics and metabolic reprogramming to promote hypoxia tolerance in yak cardiac fibroblasts" [International Journal of Biological Macromolecules, Volume 380 (2026) 154073].
Int J Biol Macromol202642772968PubTator, text miningPubMed
High-yield on-resin synthesis of doubly crosslinked α-helical peptides with significantly improved protease resistance using an isophthalic acid-based crosslinker.Eur J Med Chem202642772125PubTator, text miningPubMed
A-kinase anchoring protein complexes and cAMP signaling within the dorsal root ganglia in chronic pain.Mol Pharmacol202642664595PubTator, text miningPubMed
[Retracted] Epigenetic silencing of microRNA-199a-5p promotes the proliferation of non-small cell lung cancer cells by increasing AKAP1 expression.Oncol Lett202642577711PubTator, text miningPubMed
Norepinephrine attenuates acute lung injury by protecting mitochondria via the β2-AR-AKAP1 axis and inhibiting alveolar epithelial pyroptosis.Redox Biol202642378955PubTator, text miningPubMed
AKAP signaling: physiological and pathophysiological roles and opportunities for novel therapeutic concepts.Physiol Rev202642155599PubTator, text miningPubMed
Deciphering Bax Dynamics: Regulation, Retrotranslocation, and Mitochondrial Interplay in the Commitment to Apoptosis: A Narrative Review.Health Sci Rep202642124878PubTator, text miningPubMed
Biophysical and aerodynamic properties of a peptide targeting the A-kinase anchoring function of PI3Kγ for pulmonary cAMP modulation.Sci Rep202642009784PubTator, text miningPubMed
The Role of A-Kinase Anchoring Proteins for Inhibitory cAMP Signalling in Platelets.Cells202641892342PubTator, text miningPubMed
MYCN inhibits TrkC-mediated differentiation in neuroblastoma cells via disruption of the PKA signalling pathway.Cell Death Discov202641876468PubTator, text miningPubMed

1 to 10 of 1,448

See all 1,448 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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