Gene · 81704
DOCK8: dedicator of cytokinesis 8
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DOCK8: dedicator of cytokinesis 8. Genes, record 81704. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/81704
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8NF50 | Dedicator of cytokinesis protein 8 | 2,099 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 43468 | Q8NF50 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 14044 | Q8NF50 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 14044 | Q8NF50 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 27453 | Q8NF50 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 27453 | Q8NF50 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 27453 | Q8NF50 | Espacenet |
| JP 2023509848 A | 2023-03-10 | 40 | Q8NF50 | Espacenet |
| JP 2023509849 A | 2023-03-10 | 40 | Q8NF50 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 23415 | Q8NF50 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 126386 | Q8NF50 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants932
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DOCK8 papers | Newest fiscal year |
|---|---|---|---|
| ZIAAI001193 | Understanding DOCK8 Function in Health and Human Disease | 24 | 2025 |
| ZIAAI000646 | Transgenic Animal Models Of Human Immune Defects | 22 | 2025 |
| ZIAAI000647 | Genes And Gene Products As Immunoadjuvants | 17 | 2025 |
| ZIAAI001059 | Defining New Human Immunodeficiency and Immunodysregulation Disorders | 17 | 2025 |
| ZIAAI001247 | Primary Immune Deficiency Clinic | 16 | 2025 |
| R01AI065617 | Genetic and Epigenetic Programming of Allergic Airway Inflammation | 15 | 2025 |
| UL1TR001866 | Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success | 15 | 2025 |
| R01AI127564 | Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis | 9 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 8 | 2025 |
| ZIAAI001222 | Characterization of the cellular and molecular bases of inborn errors of immunity | 8 | 2025 |
1 to 10 of 932Source NIH's project files
See all 932 nih grantsPapers1,392
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Inborn Errors of Immunity Genotype: A Retrospective Study from the United Arab Emirates. | J Clin Immunol | 2026 | 42771195 | PubTator, text mining | PubMed |
| Recalcitrant Infectious Keratitis in DOCK8 Immunodeficiency Syndrome. | J Pediatr Ophthalmol Strabismus | 2026 | 42765610 | PubTator, text mining | PubMed |
| Connecting Skin and Gut in Dermatitis Herpetiformis: Insights from Gluten Challenge Transcriptomics. | Acta Derm Venereol | 2026 | 42713962 | PubTator, text mining | PubMed |
| Eczema in inborn errors of immunity with atopy: frequency, timing and phenotypic clustering. | Br J Dermatol | 2026 | 42485622 | PubTator, text mining | PubMed |
| Cure of DOCK8 Deficiency and Chemotherapy-Limited Burkitt Lymphoma Using TCRαβ-Depleted Haploidentical Hematopoietic Stem Cell Transplant With Memory Cell Addback. | Pediatr Blood Cancer | 2026 | 42479949 | PubTator, text mining | PubMed |
| DOCK8 in immune cells: roles and mechanisms. | Front Immunol | 2026 | 42382764 | PubTator, text mining | PubMed |
| Case Report: Hemophagocytic lymphohistiocytosis masquerading as drug-induced liver injury: successful treatment with low-dose ruxolitinib and glucocorticoids. | Front Immunol | 2026 | 42292459 | PubTator, text mining | PubMed |
| Platelet RIP2 Limits Dense Granule Release and Thrombosis via DOCK8-Cdc42. | Arterioscler Thromb Vasc Biol | 2026 | 42273729 | PubTator, text mining | PubMed |
| Editorial Expression of Concern: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. | Nat Immunol | 2026 | 42225954 | PubTator, text mining | PubMed |
| Clinical characteristics and long-term prognosis of talaromycosis in children with novel and reported inborn errors of immunity. | Front Immunol | 2026 | 42212132 | PubTator, text mining | PubMed |
1 to 10 of 1,392
See all 1,392 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/81704
GET https://conductscience.org/api/genes/v1/81704/patents