ConductScience.org, home

Gene · 81704

DOCK8: dedicator of cytokinesis 8

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. DOCK8: dedicator of cytokinesis 8. Genes, record 81704. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/81704

On this page

Gene

Symbol
DOCK8
HGNC
Name
dedicator of cytokinesis 8
HGNC
NCBI Gene ID
81704
NCBI Gene
HGNC ID
HGNC:19191
HGNC
Ensembl
ENSG00000107099
NCBI Gene
Aliases
FLJ00026, FLJ00152, FLJ00346, HEL-205, HIES2, MRD2, ZIR8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8NF50Dedicator of cytokinesis protein 82,0990Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443468Q8NF50Espacenet
EP 4641201 A22025-10-2914044Q8NF50Espacenet
JP 2025517969 A2025-06-1214044Q8NF50Espacenet
JP 2025032204 A2025-03-1127453Q8NF50Espacenet
EP 4461818 A22024-11-1327453Q8NF50Espacenet
JP 2023058610 A2023-04-2527453Q8NF50Espacenet
JP 2023509848 A2023-03-1040Q8NF50Espacenet
JP 2023509849 A2023-03-1040Q8NF50Espacenet
US 11446398 B22022-09-2023415Q8NF50Espacenet
JP 2022524081 A2022-04-27126386Q8NF50Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants932

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDOCK8 papersNewest fiscal year
ZIAAI001193Understanding DOCK8 Function in Health and Human Disease242025
ZIAAI000646Transgenic Animal Models Of Human Immune Defects222025
ZIAAI000647Genes And Gene Products As Immunoadjuvants172025
ZIAAI001059Defining New Human Immunodeficiency and Immunodysregulation Disorders172025
ZIAAI001247Primary Immune Deficiency Clinic162025
R01AI065617Genetic and Epigenetic Programming of Allergic Airway Inflammation152025
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success152025
R01AI127564Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasis92025
P30DK034854Integrated Epithelial and Muscosal Biology82025
ZIAAI001222Characterization of the cellular and molecular bases of inborn errors of immunity82025

1 to 10 of 932Source NIH's project files

See all 932 nih grants

Papers1,392

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Inborn Errors of Immunity Genotype: A Retrospective Study from the United Arab Emirates.J Clin Immunol202642771195PubTator, text miningPubMed
Recalcitrant Infectious Keratitis in DOCK8 Immunodeficiency Syndrome.J Pediatr Ophthalmol Strabismus202642765610PubTator, text miningPubMed
Connecting Skin and Gut in Dermatitis Herpetiformis: Insights from Gluten Challenge Transcriptomics.Acta Derm Venereol202642713962PubTator, text miningPubMed
Eczema in inborn errors of immunity with atopy: frequency, timing and phenotypic clustering.Br J Dermatol202642485622PubTator, text miningPubMed
Cure of DOCK8 Deficiency and Chemotherapy-Limited Burkitt Lymphoma Using TCRαβ-Depleted Haploidentical Hematopoietic Stem Cell Transplant With Memory Cell Addback.Pediatr Blood Cancer202642479949PubTator, text miningPubMed
DOCK8 in immune cells: roles and mechanisms.Front Immunol202642382764PubTator, text miningPubMed
Case Report: Hemophagocytic lymphohistiocytosis masquerading as drug-induced liver injury: successful treatment with low-dose ruxolitinib and glucocorticoids.Front Immunol202642292459PubTator, text miningPubMed
Platelet RIP2 Limits Dense Granule Release and Thrombosis via DOCK8-Cdc42.Arterioscler Thromb Vasc Biol202642273729PubTator, text miningPubMed
Editorial Expression of Concern: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.Nat Immunol202642225954PubTator, text miningPubMed
Clinical characteristics and long-term prognosis of talaromycosis in children with novel and reported inborn errors of immunity.Front Immunol202642212132PubTator, text miningPubMed

1 to 10 of 1,392

See all 1,392 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/81704

GET https://conductscience.org/api/genes/v1/81704/patents