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Gene · 81848

SPRY4: sprouty RTK signaling antagonist 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SPRY4: sprouty RTK signaling antagonist 4. Genes, record 81848. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/81848

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Gene

Symbol
SPRY4
HGNC
Name
sprouty RTK signaling antagonist 4
HGNC
NCBI Gene ID
81848
NCBI Gene
HGNC ID
HGNC:15533
HGNC
Ensembl
ENSG00000187678
NCBI Gene
Aliases
HH17
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9C004Protein sprouty homolog 42991Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465374Q9C004Espacenet
EP 4650780 A22025-11-1912975Q9C004Espacenet
JP 2025529142 A2025-09-044436Q9C004Espacenet
US 12371689 B22025-07-294436Q9C004Espacenet
JP 2025517970 A2025-06-1212975Q9C004Espacenet
US 11446398 B22022-09-2083701Q9C004Espacenet
JP 2022524081 A2022-04-27186672Q9C004Espacenet
US 11078247 B22021-08-0310932Q9C004Espacenet
WO 2021063970 A12021-04-086Q9C004Espacenet
EP 3798633 A12021-03-316Q9C004Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants738

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSPRY4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30CA016672Cancer Center Support Grant82025
P30CA030199Cancer Center Support Grant (CCSG)62025
ZIACP010144Clinical Genetic Studies of Familial and Hereditary Cancer Syndromes42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA068485Cancer Center Support Grant32025
R01CA137008Non-genomic resistance mechanisms in EGFR-mutant lung cancer32025
R01DK057819Intestinal Mucosal Growth in Health and Surgical Diseases32025
T32CA099936Translational and genomic pediatric cancer epidemiology training program32025
U54GM104942West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health32025

1 to 10 of 738Source NIH's project files

See all 738 nih grants

Papers1,447

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Macrophages as Drivers of Resistance to Dabrafenib Plus Trametinib Therapy in Anaplastic Thyroid Cancer.Int J Mol Sci202642737588PubTator, text miningPubMed
Erratum to "Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma".Research (Wash D C)202642517161PubTator, text miningPubMed
Systematic identification of pan-cancer single-gene expression biomarkers in drug high-throughput screens.PLoS One202642113851PubTator, text miningPubMed
Overlapping genetic etiology of pediatric and adult germ cell tumors.J Natl Cancer Inst202641941753PubTator, text miningPubMed
Pluripotency Factors Modulate Interferon Signaling in Embryonic Stem Cells.bioRxiv202641929074PubTator, text miningPubMed
Restoration of spermatogenesis is dependent on activation of a SPRY4-ERK checkpoint following germline stem cell damage†.Biol Reprod202641852347PubTator, text miningPubMed
Early Transcriptomic Response of Human Iris Stromal Cells During Herpes Simplex Virus Entry Reveals Interplay Between Cell Glycocalyx and Viral Exploitation.Int J Mol Sci202641751906PubTator, text miningPubMed
Characterizing mitochondrial phenotypes and MERCS in aged human skeletal muscle myoblasts.PLoS One202641719251PubTator, text miningPubMed
Serum Amyloid A (SAA) induces transcription affecting inflammation.PLoS One202641712650PubTator, text miningPubMed
YAP1 Enhances Mesenchymal-Type Gene Expression in Human Adrenergic-Type Neuroblastoma Cells.Cancers (Basel)202641681855PubTator, text miningPubMed

1 to 10 of 1,447

See all 1,447 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/81848

GET https://conductscience.org/api/genes/v1/81848/patents?page=2