Gene · 81848
SPRY4: sprouty RTK signaling antagonist 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SPRY4: sprouty RTK signaling antagonist 4. Genes, record 81848. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/81848
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9C004 | Protein sprouty homolog 4 | 299 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 65374 | Q9C004 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 12975 | Q9C004 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 4436 | Q9C004 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 4436 | Q9C004 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 12975 | Q9C004 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 83701 | Q9C004 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 186672 | Q9C004 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 10932 | Q9C004 | Espacenet |
| WO 2021063970 A1 | 2021-04-08 | 6 | Q9C004 | Espacenet |
| EP 3798633 A1 | 2021-03-31 | 6 | Q9C004 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants738
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SPRY4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 9 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| ZIACP010144 | Clinical Genetic Studies of Familial and Hereditary Cancer Syndromes | 4 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 3 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 3 | 2025 |
| R01CA137008 | Non-genomic resistance mechanisms in EGFR-mutant lung cancer | 3 | 2025 |
| R01DK057819 | Intestinal Mucosal Growth in Health and Surgical Diseases | 3 | 2025 |
| T32CA099936 | Translational and genomic pediatric cancer epidemiology training program | 3 | 2025 |
| U54GM104942 | West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health | 3 | 2025 |
1 to 10 of 738Source NIH's project files
See all 738 nih grantsPapers1,447
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Macrophages as Drivers of Resistance to Dabrafenib Plus Trametinib Therapy in Anaplastic Thyroid Cancer. | Int J Mol Sci | 2026 | 42737588 | PubTator, text mining | PubMed |
| Erratum to "Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma". | Research (Wash D C) | 2026 | 42517161 | PubTator, text mining | PubMed |
| Systematic identification of pan-cancer single-gene expression biomarkers in drug high-throughput screens. | PLoS One | 2026 | 42113851 | PubTator, text mining | PubMed |
| Overlapping genetic etiology of pediatric and adult germ cell tumors. | J Natl Cancer Inst | 2026 | 41941753 | PubTator, text mining | PubMed |
| Pluripotency Factors Modulate Interferon Signaling in Embryonic Stem Cells. | bioRxiv | 2026 | 41929074 | PubTator, text mining | PubMed |
| Restoration of spermatogenesis is dependent on activation of a SPRY4-ERK checkpoint following germline stem cell damage†. | Biol Reprod | 2026 | 41852347 | PubTator, text mining | PubMed |
| Early Transcriptomic Response of Human Iris Stromal Cells During Herpes Simplex Virus Entry Reveals Interplay Between Cell Glycocalyx and Viral Exploitation. | Int J Mol Sci | 2026 | 41751906 | PubTator, text mining | PubMed |
| Characterizing mitochondrial phenotypes and MERCS in aged human skeletal muscle myoblasts. | PLoS One | 2026 | 41719251 | PubTator, text mining | PubMed |
| Serum Amyloid A (SAA) induces transcription affecting inflammation. | PLoS One | 2026 | 41712650 | PubTator, text mining | PubMed |
| YAP1 Enhances Mesenchymal-Type Gene Expression in Human Adrenergic-Type Neuroblastoma Cells. | Cancers (Basel) | 2026 | 41681855 | PubTator, text mining | PubMed |
1 to 10 of 1,447
See all 1,447 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/81848
GET https://conductscience.org/api/genes/v1/81848/patents?page=2