Gene · 8192
CLPP: caseinolytic mitochondrial matrix peptidase proteolytic subunit
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CLPP: caseinolytic mitochondrial matrix peptidase proteolytic subunit. Genes, record 8192. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8192
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16740 | ATP-dependent Clp protease proteolytic subunit, mitochondrial | 277 | 29 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026120675 A | 2026-07-22 | 780 | Q16740 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 41680 | Q16740 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 12183 | Q16740 | Espacenet |
| US 11918604 B2 | 2024-03-05 | 7 | Q16740 | Espacenet |
| US 11918605 B1 | 2024-03-05 | 7 | Q16740 | Espacenet |
| KR 1020230069042 A | 2023-05-18 | 780 | Q16740 | Espacenet |
| JP 2023518295 A | 2023-04-28 | 770 | Q16740 | Espacenet |
| US 11517589 B2 | 2022-12-06 | 7 | Q16740 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 12183 | Q16740 | Espacenet |
| US 11376242 B2 | 2022-07-05 | 1 | Q16740 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,148
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CLPP papers | Newest fiscal year |
|---|---|---|---|
| ZIABC008710 | Molecular Chaperones and DNA Replication | 15 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| ZIADC000039 | Identification of Genes Causing Syndromic and Nonsyndromic Hearing Impairment | 6 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 5 | 2025 |
| R01GM032543 | Physical Chemistry of Nucleic Acids | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 4 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 4 | 2025 |
| R01NS113793 | HDAC Inhibitors Reverse the Warburg Effect and Elicit Metabolic Vulnerabilities in Model Systems of Glioblastoma | 4 | 2025 |
| R35GM118141 | Mitochondrial Biogenesis in Health and Disease | 4 | 2025 |
1 to 10 of 1,148Source NIH's project files
See all 1,148 nih grantsPapers2,606
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| ONC201/dordaviprone for H3 K27M-mutant tumors: Discovery, mechanisms, therapeutic potential, and future directions. | Genes Dis | 2027 | 42751161 | PubTator, text mining | PubMed |
| Development of High-Efficiency Mitochondrial Protease Targeting Chimeras (MtPTACs) for Targeted Degradation of POLRMT and Beyond. | JACS Au | 2026 | 42819300 | PubTator, text mining | PubMed |
| Targeting ClpP Rewires the Metabolic-Immune Axis in Acute Myeloid Leukemia. | Cancer Res | 2026 | 42804164 | PubTator, text mining | PubMed |
| CLPP loss confers sex-specific protection from renal ischemia reperfusion injury. | Redox Biol | 2026 | 42800460 | PubTator, text mining | PubMed |
| Mitochondrial CLPP in Health and Disease: Mechanisms, Therapeutic Duality and Emerging Opportunities. | J Inherit Metab Dis | 2026 | 42687680 | PubTator, text mining | PubMed |
| Metformin activates the mitochondrial unfolded protein response via the AMPK/SIRT1 pathway to delay intervertebral disc degeneration. | Free Radic Biol Med | 2026 | 42685933 | PubTator, text mining | PubMed |
| Design, Synthesis, and Structure-Activity Relationships of Novel Piperidine-Fused Imidazolone ClpP Activators as Potential Anti-Cancer Agents. | Molecules | 2026 | 42653996 | PubTator, text mining | PubMed |
| Plastome convergence across endoparasitic plant lineages: genome reduction, high AT bias, elevated substitution rates, and functional persistence in Mitrastemon yamamotoi. | Ann Bot | 2026 | 42548282 | PubTator, text mining | PubMed |
| An adaptor for feedback regulation of heme biosynthesis by a mitochondrial protease. | Science | 2026 | 42531414 | PubTator, text mining | PubMed |
| Interplay of Epigenetic Reprogramming, Mitochondrial Metabolism, and Dopamine Signalling Pathways Uncovers Metabolic Vulnerabilities in Diffuse Midline Glioma. | Cancers (Basel) | 2026 | 42512251 | PubTator, text mining | PubMed |
1 to 10 of 2,606
See all 2,606 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8192
GET https://conductscience.org/api/genes/v1/8192/patents?page=2