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Gene · 8192

CLPP: caseinolytic mitochondrial matrix peptidase proteolytic subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CLPP: caseinolytic mitochondrial matrix peptidase proteolytic subunit. Genes, record 8192. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8192

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Gene

Symbol
CLPP
HGNC
Name
caseinolytic mitochondrial matrix peptidase proteolytic subunit
HGNC
NCBI Gene ID
8192
NCBI Gene
HGNC ID
HGNC:2084
HGNC
Ensembl
ENSG00000125656
NCBI Gene
Aliases
DFNB81, PRLTS3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16740ATP-dependent Clp protease proteolytic subunit, mitochondrial27729Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026120675 A2026-07-22780Q16740Espacenet
JP 2026004568 A2026-01-1441680Q16740Espacenet
JP 2025062604 A2025-04-1412183Q16740Espacenet
US 11918604 B22024-03-057Q16740Espacenet
US 11918605 B12024-03-057Q16740Espacenet
KR 1020230069042 A2023-05-18780Q16740Espacenet
JP 2023518295 A2023-04-28770Q16740Espacenet
US 11517589 B22022-12-067Q16740Espacenet
US 11446398 B22022-09-2012183Q16740Espacenet
US 11376242 B22022-07-051Q16740Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,148

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCLPP papersNewest fiscal year
ZIABC008710Molecular Chaperones and DNA Replication152025
P30CA016672Cancer Center Support Grant102025
ZIADC000039Identification of Genes Causing Syndromic and Nonsyndromic Hearing Impairment62025
P30CA010815Consolidated Basic Cancer Research Program52025
R01GM032543Physical Chemistry of Nucleic Acids52025
P30CA008748Cancer Center Support Grant42025
P30CA016056Roswell Park Cancer Center Support Grant42025
P40OD010440Caenorhabditis Genetics Center42025
R01NS113793HDAC Inhibitors Reverse the Warburg Effect and Elicit Metabolic Vulnerabilities in Model Systems of Glioblastoma42025
R35GM118141Mitochondrial Biogenesis in Health and Disease42025

1 to 10 of 1,148Source NIH's project files

See all 1,148 nih grants

Papers2,606

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
ONC201/dordaviprone for H3 K27M-mutant tumors: Discovery, mechanisms, therapeutic potential, and future directions.Genes Dis202742751161PubTator, text miningPubMed
Development of High-Efficiency Mitochondrial Protease Targeting Chimeras (MtPTACs) for Targeted Degradation of POLRMT and Beyond.JACS Au202642819300PubTator, text miningPubMed
Targeting ClpP Rewires the Metabolic-Immune Axis in Acute Myeloid Leukemia.Cancer Res202642804164PubTator, text miningPubMed
CLPP loss confers sex-specific protection from renal ischemia reperfusion injury.Redox Biol202642800460PubTator, text miningPubMed
Mitochondrial CLPP in Health and Disease: Mechanisms, Therapeutic Duality and Emerging Opportunities.J Inherit Metab Dis202642687680PubTator, text miningPubMed
Metformin activates the mitochondrial unfolded protein response via the AMPK/SIRT1 pathway to delay intervertebral disc degeneration.Free Radic Biol Med202642685933PubTator, text miningPubMed
Design, Synthesis, and Structure-Activity Relationships of Novel Piperidine-Fused Imidazolone ClpP Activators as Potential Anti-Cancer Agents.Molecules202642653996PubTator, text miningPubMed
Plastome convergence across endoparasitic plant lineages: genome reduction, high AT bias, elevated substitution rates, and functional persistence in Mitrastemon yamamotoi.Ann Bot202642548282PubTator, text miningPubMed
An adaptor for feedback regulation of heme biosynthesis by a mitochondrial protease.Science202642531414PubTator, text miningPubMed
Interplay of Epigenetic Reprogramming, Mitochondrial Metabolism, and Dopamine Signalling Pathways Uncovers Metabolic Vulnerabilities in Diffuse Midline Glioma.Cancers (Basel)202642512251PubTator, text miningPubMed

1 to 10 of 2,606

See all 2,606 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8192

GET https://conductscience.org/api/genes/v1/8192/patents?page=2