Gene · 823
CAPN1: calpain 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CAPN1: calpain 1. Genes, record 823. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/823
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P07384 | Calpain-1 catalytic subunit | 714 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents124
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 3058 | P07384 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2617 | P07384 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2617 | P07384 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3058 | P07384 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 11105 | P07384 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 11108 | P07384 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 11110 | P07384 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 11114 | P07384 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 11117 | P07384 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 25749 | P07384 | Espacenet |
1 to 10 of 124
See all 124 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,390
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CAPN1 papers | Newest fiscal year |
|---|---|---|---|
| ZIAAG000236 | Calpain-1 Activity and Central Arterial Aging | 8 | 2025 |
| ZIAAG000237 | Age-Associated Changes in Arterial Proteome and Aortic Smooth Muscle Signaling | 8 | 2025 |
| ZIAAG000239 | Effect of Metalloprotease Inhibition on Age-Associated Arterial Remodeling | 7 | 2025 |
| ZIAAG000240 | Progression of Arterial Aging: the Local MCP-1/MMP-2/TGF-beta 1 Signaling Loop | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| R15MH101703 | Investigating the roles of UBE3A and TRPML1 in extracellular vesicle regulation to understand Angelman syndrome pathogenesis | 5 | 2025 |
| P20GM113226 | Hepatobiology and Toxicology COBRE | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| U19AI070235 | Epithelial Genes in Allergic Inflammation | 4 | 2025 |
| ZIAAG000238 | Effects of Aging on Experimental Atherosclerosis in Nonhuman Primates | 4 | 2025 |
1 to 10 of 1,390Source NIH's project files
See all 1,390 nih grantsPapers2,391
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| CAPN1 promotes the progression of MLL-rearranged acute myeloid leukemia by suppressing SHP-1 and activating MAPK/ERK signaling pathway. | Biochim Biophys Acta Mol Basis Dis | 2027 | 42722135 | PubTator, text mining | PubMed |
| α1-Antitrypsin attenuates microglial NLR family pyrin domain containing 3 inflammasome activation via cannabinoid receptor 2 signaling to ameliorate α-synucleinopathy-related behavioral deficits. | Mol Biomed | 2026 | 42763829 | PubTator, text mining | PubMed |
| Calcium-dependent proteolysis of the chimeric androglobin reveals altered localization of its isolated globin domain. | J Biol Chem | 2026 | 42759662 | PubTator, text mining | PubMed |
| A 3D Human Neuron-on-Chip Platform to Monitor Neuronal Injury Responses. | Adv Healthc Mater | 2026 | 42529940 | PubTator, text mining | PubMed |
| A 3D Human Neuron-on-Chip Platform to Monitor Neuronal Injury Responses. | bioRxiv | 2026 | 42427570 | PubTator, text mining | PubMed |
| Beef carcass electrical stimulation enhances Calpain-1 autolysis but not proteolysis. | Meat Sci | 2026 | 42418871 | PubTator, text mining | PubMed |
| Serum CAPN1 and CLEC2 as Biomarkers for Hearing Loss Severity and Internal Auditory Artery Narrowing in Sudden Sensorineural Hearing Loss. | Int J Gen Med | 2026 | 42266444 | PubTator, text mining | PubMed |
| Genomic Landscape and Phenotypic Spectrum of Autosomal Recessive Cerebellar Ataxia in China. | Mov Disord | 2026 | 42243046 | PubTator, text mining | PubMed |
| Narrative review of rationale for IV deferoxamine plus intranasal insulin to ameliorate brain damage following resuscitation from cardiac arrest. | Resusc Plus | 2026 | 42164175 | PubTator, text mining | PubMed |
| Genetic architecture of hereditary spastic paraplegia: from monogenic to oligogenic models. | J Neurogenet | 2026 | 42150761 | PubTator, text mining | PubMed |
1 to 10 of 2,391
See all 2,391 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/823
GET https://conductscience.org/api/genes/v1/823/patents?page=2