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Gene · 823

CAPN1: calpain 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CAPN1: calpain 1. Genes, record 823. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/823

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Gene

Symbol
CAPN1
HGNC
Name
calpain 1
HGNC
NCBI Gene ID
823
NCBI Gene
HGNC ID
HGNC:1476
HGNC
Ensembl
ENSG00000014216
NCBI Gene
Aliases
CANP, CANP1, CANPL1, SPG76, muCANP, muCL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P07384Calpain-1 catalytic subunit7145Ensembl, GeneID, HGNC

Source UniProt

Patents124

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193058P07384Espacenet
EP 4641201 A22025-10-292617P07384Espacenet
JP 2025517969 A2025-06-122617P07384Espacenet
JP 2025517970 A2025-06-123058P07384Espacenet
JP 2025062604 A2025-04-1411105P07384Espacenet
JP 2025062604 A2025-04-1411108P07384Espacenet
JP 2025062604 A2025-04-1411110P07384Espacenet
JP 2025062604 A2025-04-1411114P07384Espacenet
JP 2025062604 A2025-04-1411117P07384Espacenet
JP 2025032204 A2025-03-1125749P07384Espacenet

1 to 10 of 124

See all 124 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,390

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCAPN1 papersNewest fiscal year
ZIAAG000236Calpain-1 Activity and Central Arterial Aging82025
ZIAAG000237Age-Associated Changes in Arterial Proteome and Aortic Smooth Muscle Signaling82025
ZIAAG000239Effect of Metalloprotease Inhibition on Age-Associated Arterial Remodeling72025
ZIAAG000240Progression of Arterial Aging: the Local MCP-1/MMP-2/TGF-beta 1 Signaling Loop72025
P30CA016672Cancer Center Support Grant62025
R15MH101703Investigating the roles of UBE3A and TRPML1 in extracellular vesicle regulation to understand Angelman syndrome pathogenesis52025
P20GM113226Hepatobiology and Toxicology COBRE42025
P30CA008748Cancer Center Support Grant42025
U19AI070235Epithelial Genes in Allergic Inflammation42025
ZIAAG000238Effects of Aging on Experimental Atherosclerosis in Nonhuman Primates42025

1 to 10 of 1,390Source NIH's project files

See all 1,390 nih grants

Papers2,391

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
CAPN1 promotes the progression of MLL-rearranged acute myeloid leukemia by suppressing SHP-1 and activating MAPK/ERK signaling pathway.Biochim Biophys Acta Mol Basis Dis202742722135PubTator, text miningPubMed
α1-Antitrypsin attenuates microglial NLR family pyrin domain containing 3 inflammasome activation via cannabinoid receptor 2 signaling to ameliorate α-synucleinopathy-related behavioral deficits.Mol Biomed202642763829PubTator, text miningPubMed
Calcium-dependent proteolysis of the chimeric androglobin reveals altered localization of its isolated globin domain.J Biol Chem202642759662PubTator, text miningPubMed
A 3D Human Neuron-on-Chip Platform to Monitor Neuronal Injury Responses.Adv Healthc Mater202642529940PubTator, text miningPubMed
A 3D Human Neuron-on-Chip Platform to Monitor Neuronal Injury Responses.bioRxiv202642427570PubTator, text miningPubMed
Beef carcass electrical stimulation enhances Calpain-1 autolysis but not proteolysis.Meat Sci202642418871PubTator, text miningPubMed
Serum CAPN1 and CLEC2 as Biomarkers for Hearing Loss Severity and Internal Auditory Artery Narrowing in Sudden Sensorineural Hearing Loss.Int J Gen Med202642266444PubTator, text miningPubMed
Genomic Landscape and Phenotypic Spectrum of Autosomal Recessive Cerebellar Ataxia in China.Mov Disord202642243046PubTator, text miningPubMed
Narrative review of rationale for IV deferoxamine plus intranasal insulin to ameliorate brain damage following resuscitation from cardiac arrest.Resusc Plus202642164175PubTator, text miningPubMed
Genetic architecture of hereditary spastic paraplegia: from monogenic to oligogenic models.J Neurogenet202642150761PubTator, text miningPubMed

1 to 10 of 2,391

See all 2,391 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/823

GET https://conductscience.org/api/genes/v1/823/patents?page=2