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Gene · 8239

USP9X: ubiquitin specific peptidase 9 X-linked

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. USP9X: ubiquitin specific peptidase 9 X-linked. Genes, record 8239. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8239

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Gene

Symbol
USP9X
HGNC
Name
ubiquitin specific peptidase 9 X-linked
HGNC
NCBI Gene ID
8239
NCBI Gene
HGNC ID
HGNC:12632
HGNC
Ensembl
ENSG00000124486
NCBI Gene
Aliases
DFFRX, FAF, FAF-X, FAM, MRX99, MRXS99F, XLID99, hFAM
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q93008Ubiquitin carboxyl-terminal hydrolase 9X2,5544Ensembl, GeneID, HGNC

Source UniProt

Patents14

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469028Q93008Espacenet
EP 4650780 A22025-11-1910029Q93008Espacenet
EP 4641201 A22025-10-2910309Q93008Espacenet
JP 2025517969 A2025-06-1210309Q93008Espacenet
JP 2025517970 A2025-06-1210029Q93008Espacenet
JP 2023551068 A2023-12-06238Q93008Espacenet
US 11446398 B22022-09-2095059Q93008Espacenet
JP 2022524081 A2022-04-27198030Q93008Espacenet
JP 2019054813 A2019-04-11249463Q93008Espacenet
JP 2017121241 A2017-07-13249463Q93008Espacenet

1 to 10 of 14

See all 14 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,243

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUSP9X papersNewest fiscal year
P30CA016672Cancer Center Support Grant142025
P30CA008748Cancer Center Support Grant72025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)72025
P20GM103430Rhode Island IDeA Network of Biomedical Research Excellence62025
P30CA021765Cancer Center Support Grant (CCSG)52025
R01EY026635Protein-polymer nanomedicine for Sjogren's Syndrome52025
R01MH107182Postsynaptic roles of ankyrins52025
P30CA016058Cancer Center Support Grant42025
P30CA047904Cancer Center Support Grant42025
P30CA091842Cancer Center Support Grant42025

1 to 10 of 1,243Source NIH's project files

See all 1,243 nih grants

Papers1,917

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Transketolase-like 1 potentiates PD-1 blockade in hepatocellular carcinoma by glycolysis to prime dendritic cell lactylation.Signal Transduct Target Ther202642802226PubTator, text miningPubMed
Interactions Between E3 Ubiquitin Ligases and Deubiquitinases in AKT Regulation: Implications in Skeletal Muscle Homeostasis.Cell Biochem Funct202642671015PubTator, text miningPubMed
Atractylenolide I alleviates LPS-induced pulmonary cell injury relevant to pediatric pneumonia via the ERK/USP9X/Mcl-1 and Akt/Survivin axes.Naunyn Schmiedebergs Arch Pharmacol202642624927PubTator, text miningPubMed
Palmitoylation of TK1 exacerbates osteoarthritis by promoting JNK-mediated metabolic reprogramming.Proc Natl Acad Sci U S A202642546205PubTator, text miningPubMed
Insufficiency of cohesin regulatory protein PDS5B triggers meiotic failure and aneuploidy in oocytes during advanced maternal aging.Proc Natl Acad Sci U S A202642531021PubTator, text miningPubMed
The Deubiquitinating Enzyme USP9X Regulates the Protein Stability of the FAM49B in Clear Cell Renal Cell Carcinoma.J Proteome Res202642463156PubTator, text miningPubMed
Bioinformatics screening identifies USP9X as a pathogenic gene underlying thyroid and breast cancer comorbidity.J Mol Histol202642417888PubTator, text miningPubMed
USP9X trims STAT1 to curb oncostatin M activity and intestinal inflammation.Cell Mol Immunol202642350601PubTator, text miningPubMed
HSPA6 Confers Lenvatinib Resistance in Hepatocellular Carcinoma by Promoting Phase Separation-Mediated TXNRD1 Stabilization to Suppress Ferroptosis.Cancer Res202642314062PubTator, text miningPubMed
Recurrent COPA mutation drives R-spondin-independent Wnt activation in intestinal tumors.Nat Genet202642286202PubTator, text miningPubMed

1 to 10 of 1,917

See all 1,917 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8239

GET https://conductscience.org/api/genes/v1/8239/patents