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Gene · 824

CAPN2: calpain 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CAPN2: calpain 2. Genes, record 824. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/824

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Gene

Symbol
CAPN2
HGNC
Name
calpain 2
HGNC
NCBI Gene ID
824
NCBI Gene
HGNC ID
HGNC:1479
HGNC
Ensembl
ENSG00000162909
NCBI Gene
Aliases
CANP2, CANPL2, CANPml, mCANP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17655Calpain-2 catalytic subunit7003Ensembl, GeneID, HGNC

Source UniProt

Patents17

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193586P17655Espacenet
EP 4641201 A22025-10-293178P17655Espacenet
JP 2025517969 A2025-06-123178P17655Espacenet
JP 2025517970 A2025-06-123586P17655Espacenet
JP 2025062604 A2025-04-1411153P17655Espacenet
JP 2024123008 A2024-09-105268P17655Espacenet
US 11446398 B22022-09-2011153P17655Espacenet
JP 2022524081 A2022-04-27114124P17655Espacenet
US 10501513 B22019-12-105268P17655Espacenet
JP 2017197545 A2017-11-0229969P17655Espacenet

1 to 10 of 17

See all 17 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,280

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCAPN2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
R01CA085862Adhesive regulation during cell migration72025
P30DK020579Diabetes Research Center52025
P30EY026877Stanford Vision Research Core52025
R01EY024698Gene Editing and Silencing in Phototransduction52025
R15MH101703Investigating the roles of UBE3A and TRPML1 in extracellular vesicle regulation to understand Angelman syndrome pathogenesis52025
I01BX001262Hormonal Intervention Protects Axon-myelin to Promote Functional Recovery in SCI42025
P30CA013696Cancer Center Support Grant32025
P30EY008126Core Grant in Vision Research32025
R01AI124355Genetic and Immunological Dissection of Eosinophilic Esophagitis32025

1 to 10 of 1,280Source NIH's project files

See all 1,280 nih grants

Papers2,355

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A prostate cancer-specific super-enhancer at 1q42.3 regulates the CAPN2 and KRT19.J Biol Chem202642772564PubTator, text miningPubMed
Calcium-dependent proteolysis of the chimeric androglobin reveals altered localization of its isolated globin domain.J Biol Chem202642759662PubTator, text miningPubMed
Calpain-2 as a therapeutic target for sodium danshensu in mitigating myocardial ischaemia-reperfusion injury.Br J Pharmacol202642615330PubTator, text miningPubMed
Calpain-2 inhibition prevents pressure overload-induced lysosomal cathepsin release and cardiac hypertrophy.Life Sci202642567498PubTator, text miningPubMed
Genome-wide association susceptibility loci for cluster headache support a role for inflammation in the pathophysiology.J Headache Pain202642557554PubTator, text miningPubMed
Gut microbiome derived folate metabolite suppresses colorectal cancer progression.bioRxiv202642523540PubTator, text miningPubMed
DINCH exposure contributes to osteoarthritis pathogenesis via TSPO-mediated chondrotoxicity: Evidence from in silico prediction to experimental validation.Chem Biol Interact202642501774PubTator, text miningPubMed
Therapeutic potential of pachymic acid in glioma: a comprehensive approach combining experimental validation, network pharmacology, and machine learning.Brain Res202642468874PubTator, text miningPubMed
Preclinical evaluation of cysteine protease-inhibitor aloxistatin (E64d) for heart failure therapy.J Mol Med (Berl)202642343037PubTator, text miningPubMed
Integrated network toxicology and experimental validation to investigate potential mechanisms associated with aspartame-induced malignant phenotypic changes in colorectal cancer.Naunyn Schmiedebergs Arch Pharmacol202642319418PubTator, text miningPubMed

1 to 10 of 2,355

See all 2,355 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/824

GET https://conductscience.org/api/genes/v1/824/patents