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Gene · 8242

KDM5C: lysine demethylase 5C

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KDM5C: lysine demethylase 5C. Genes, record 8242. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8242

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Gene

Symbol
KDM5C
HGNC
Name
lysine demethylase 5C
HGNC
NCBI Gene ID
8242
NCBI Gene
HGNC ID
HGNC:11114
HGNC
Ensembl
ENSG00000126012
NCBI Gene
Aliases
DXS1272E, JARID1C, MRX13, MRXJ, MRXS16, MRXSCJ, MRXSJ, SMCX, XE169
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41229Lysine-specific demethylase 5C1,5602Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1452096P41229Espacenet
EP 4650780 A22025-11-199617P41229Espacenet
EP 4641201 A22025-10-299880P41229Espacenet
JP 2025147176 A2025-10-0615203P41229Espacenet
JP 2025517969 A2025-06-129880P41229Espacenet
JP 2025517970 A2025-06-129617P41229Espacenet
JP 2025032204 A2025-03-1130484P41229Espacenet
JP 2025028160 A2025-02-2815203P41229Espacenet
KR 1020250010750 A2025-01-2115203P41229Espacenet
EP 4461818 A22024-11-1330484P41229Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,367

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKDM5C papersNewest fiscal year
P30CA008748Cancer Center Support Grant532025
P30CA016672Cancer Center Support Grant182025
T32CA082088T32 Urologic Oncology Research Training Grant172025
P50CA101942DF/HCC Kidney Cancer SPORE (supplement)152025
P30CA006927Comprehensive Cancer Center Program at Fox Chase102025
ZIABC011038Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene102025
T32HD079342Career Training in Reproductive Biology82025
UL1TR001863Yale Clinical and Translational Science Award82025
ZIDBC011089Clinical Nursing and Data Management Core82025
P30CA013330Cancer Center Support Grant72025

1 to 10 of 1,367Source NIH's project files

See all 1,367 nih grants

Papers1,955

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
HIF-1α-mediated regulation of ATG7 and KDM5C in ferroptosis.FEBS J202642634453PubTator, text miningPubMed
Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti-TIM3 Immunotherapy.Adv Sci (Weinh)202642606075PubTator, text miningPubMed
Germline predisposition and somatic mutational landscape in synchronous mucinous metaplasia and neoplasia of the female genital tract.Clin Transl Med202642605498PubTator, text miningPubMed
Progressive Cerebellar Atrophy Associated with a KDM5C Variant.JMA J202642577055PubTator, text miningPubMed
CT-Based Radiomics for Prediction of Molecular Markers in Clear Cell Renal Cell Carcinoma: A Comprehensive Review.Medicina (Kaunas)202642512891PubTator, text miningPubMed
SNORA23-KDM5C epigenetic axis mediates dual DNA repair pathways to drive radioresistance in esophageal squamous cell carcinoma.Cell Death Differ202642448921PubTator, text miningPubMed
Epigenomic dysregulation in the bone marrow mesenchymal stem cells of acquired aplastic anemia patients: An in silico and in vitro study.Mol Biol Rep202642429854PubTator, text miningPubMed
Reprogramming of valine metabolism mediated by abnormally low ALDH6A1 expression promotes invasive metastasis of gastric cancer.Sci Adv202642418576PubTator, text miningPubMed
Epigenetic regulation of cardiac physiology and pathophysiology: biological sex matters.J Cardiovasc Aging202642369572PubTator, text miningPubMed
The histone demethylase KDM5C aggravates titanium particle-induced osteolysis by promoting macrophage inflammation and osteoclastogenesis.Cell Mol Life Sci202642360493PubTator, text miningPubMed

1 to 10 of 1,955

See all 1,955 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8242

GET https://conductscience.org/api/genes/v1/8242/patents?page=2