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Gene · 8243

SMC1A: structural maintenance of chromosomes 1A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SMC1A: structural maintenance of chromosomes 1A. Genes, record 8243. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8243

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Gene

Symbol
SMC1A
HGNC
Name
structural maintenance of chromosomes 1A
HGNC
NCBI Gene ID
8243
NCBI Gene
HGNC ID
HGNC:11111
HGNC
Ensembl
ENSG00000072501
NCBI Gene
Aliases
CDLS2, DEE85, DXS423E, EIEE85, KIAA0178, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, Smcb
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14683Structural maintenance of chromosomes protein 1A1,23318Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-195493Q14683Espacenet
EP 4641201 A22025-10-295107Q14683Espacenet
JP 2025517969 A2025-06-125107Q14683Espacenet
JP 2025517970 A2025-06-125493Q14683Espacenet
JP 2024178415 A2024-12-248268Q14683Espacenet
JP 2024123008 A2024-09-108570Q14683Espacenet
JP 2023549761 A2023-11-29238Q14683Espacenet
US 11708396 B22023-07-252344Q14683Espacenet
US 11446398 B22022-09-2084682Q14683Espacenet
JP 2022529532 A2022-06-228268Q14683Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,173

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSMC1A papersNewest fiscal year
P30CA016672Cancer Center Support Grant262025
P30CA008748Cancer Center Support Grant172025
R01CA142861Renewal: HPV and the DNA Damage Response152025
P30CA010815Consolidated Basic Cancer Research Program142025
P30CA021765Cancer Center Support Grant (CCSG)142025
R01HG003143Structural Annotation of the Human Genome122025
R01CA117830Epigenomic Control of KSHV Latency102025
P30CA016058Cancer Center Support Grant92025
U10CA180821Alliance for Clinical Trials in Oncology Operations Center - GY11 Funded Extension92025
U10CA180882Alliance Statistics and Data Management Center92025

1 to 10 of 2,173Source NIH's project files

See all 2,173 nih grants

Papers2,883

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
SMC1A drives radioresistance in lung squamous cell carcinoma through the ILF2/RNF2 axis.Biochim Biophys Acta Mol Basis Dis202742727711PubTator, text miningPubMed
SMC1A is required for fate determinations of human spermatogonial stem cells and male fertility by interacting with YBX1 and stabilizing HMGA2 mRNA via an m5C modification.Cell Death Differ202642745033PubTator, text miningPubMed
Identification of candidate variants in plasma associated with early versus late disease progression under anti-PD-1 therapy in metastatic NSCLC.Transl Lung Cancer Res202642723788PubTator, text miningPubMed
A Novel De Novo STAG1 Variant at the RAD21 Binding Interface Is Associated With Hypoglycemia, Recurrent Fever, Immunodeficiency and Features of Classical Cohesinopathies.Clin Genet202642713681PubTator, text miningPubMed
Erratum: tRF-20-M0NK5Y93-induced MALAT1 promotes colon cancer metastasis through alternative splicing of SMC1A.Am J Cancer Res202642597481PubTator, text miningPubMed
Case Report: Immune-driven clonal selection underlying lineage switch from B-Precursor acute lymphoblastic leukemia to acute myeloid leukemia following inotuzumab ozogamicin.Front Immunol202642591212PubTator, text miningPubMed
Diagnostic delay in infants with very early-onset rare and ultra-rare genetic epilepsies.Dev Med Child Neurol202642573089PubTator, text miningPubMed
Chromosome Architecture Defined by the Meiosis-Specific Cohesin in Mammalian Germ Cells.Adv Exp Med Biol202642455438PubTator, text miningPubMed
Epigenetic regulation of cardiac physiology and pathophysiology: biological sex matters.J Cardiovasc Aging202642369572PubTator, text miningPubMed
The relationship between cerebellar functional connectivity alterations and hand dexterity impairment in multiple sclerosis.J Neurol202642360506PubTator, text miningPubMed

1 to 10 of 2,883

See all 2,883 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8243

GET https://conductscience.org/api/genes/v1/8243/patents?page=2