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Gene · 8301

PICALM: phosphatidylinositol binding clathrin assembly protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PICALM: phosphatidylinositol binding clathrin assembly protein. Genes, record 8301. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8301

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Gene

Symbol
PICALM
HGNC
Name
phosphatidylinositol binding clathrin assembly protein
HGNC
NCBI Gene ID
8301
NCBI Gene
HGNC ID
HGNC:15514
HGNC
Ensembl
ENSG00000073921
NCBI Gene
Aliases
CALM, CLTH, LAP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13492Phosphatidylinositol-binding clathrin assembly protein6520Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1457588Q13492Espacenet
JP 2026004568 A2026-01-1457589Q13492Espacenet
EP 4650780 A22025-11-1911015Q13492Espacenet
JP 2025517970 A2025-06-1211015Q13492Espacenet
JP 2025062601 A2025-04-1424Q13492Espacenet
US 11446398 B22022-09-2062542Q13492Espacenet
JP 2022524081 A2022-04-27165513Q13492Espacenet
JP 2022523514 A2022-04-2524Q13492Espacenet
JP 2019054813 A2019-04-11238023Q13492Espacenet
JP 2019054813 A2019-04-11238024Q13492Espacenet

1 to 10 of 20

See all 20 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,276

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePICALM papersNewest fiscal year
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)1122025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions262025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study202025
R01NS017950Precursors of Stroke Incidence and Prognosis162025
U24AG041689THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITE162025
U24AG056270National Institute on Aging Alzheimer's Disease Family-Based Study (NIA-AD FBS)142025
U19AG024904Alzheimer's Disease Neuroimaging Initiative (ADNI4)122025
P30AG072975Rush Alzheimer's Disease Research Center102025
U54AG052427Genome Center for Alzheimer's Disease (GCAD)92025
P30CA008748Cancer Center Support Grant82025

1 to 10 of 2,276Source NIH's project files

See all 2,276 nih grants

Papers2,227

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Molecular and genetic basis of alzheimer's disease and emerging treatment Modalities.Neurodegener Dis Manag202642825454PubTator, text miningPubMed
Integrated plasma proteomic and metabolomic profiling demonstrated specific proteins and bile acids remodeling after liver transplantation of children with biliary atresia.Biochim Biophys Acta Proteins Proteom202642777789PubTator, text miningPubMed
Population Attributable Risk in Alzheimer and Parkinson Diseases.Neurol Genet202642639394PubTator, text miningPubMed
Tau dysfunction in alzheimer's disease: molecular and cellular mechanisms, genetic modulation, and therapeutic perspectives.Mol Biol Rep202642593621PubTator, text miningPubMed
Assessment of paralogue annotation for improving diagnostic accuracy in CALM1, CALM2, and CALM3 genes.Front Genet202642524612PubTator, text miningPubMed
Subtle cortical thinning in the temporal pole in middle-aged APOE-ε4 and PICALM (rs3851179) AA/AG carriers without dementia.Neurobiol Aging202642508146PubTator, text miningPubMed
Disease-predominant loci across Alzheimer's disease, Parkinson's disease and Lewy body dementia: evidence from the UK Biobank prospective cohort, conditional GWAS and colocalization.Front Genet202642460153PubTator, text miningPubMed
Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.PLoS Genet202642371968PubTator, text miningPubMed
Microglial PICALM: A novel genetic driver and therapeutic target in vascular dementia.Arch Gerontol Geriatr202642250393PubTator, text miningPubMed
Shared Genetic Architecture Between Kidney Function and Alzheimer Disease Across Ancestries.medRxiv202642006785PubTator, text miningPubMed

1 to 10 of 2,227

See all 2,227 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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