Gene · 8317
CDC7: cell division cycle 7
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CDC7: cell division cycle 7. Genes, record 8317. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8317
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O00311 | Cell division cycle 7-related protein kinase | 574 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents57
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 40787 | O00311 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 40790 | O00311 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 892 | O00311 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 629 | O00311 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 629 | O00311 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 892 | O00311 | Espacenet |
| US 11976334 B2 | 2024-05-07 | 129 | O00311 | Espacenet |
| US 11860162 B2 | 2024-01-02 | 1545 | O00311 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 13759 | O00311 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 13760 | O00311 | Espacenet |
1 to 10 of 57
See all 57 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| BMS-863233 | CHEMBL3544944 | Cell division cycle 7-related protein kinase inhibitor | INHIBITOR | ChEMBL |
| NMS-1116354 | CHEMBL3545321 | Cell division cycle 7-related protein kinase inhibitor | INHIBITOR | ChEMBL |
| RXDX-103 | CHEMBL3545090 | Cell division cycle 7-related protein kinase inhibitor | INHIBITOR | ChEMBL |
| SIMUROSERTIB | CHEMBL4297644 | Cell division cycle 7-related protein kinase inhibitor | INHIBITOR | ChEMBL |
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT03261947 | SIMUROSERTIB | PHASE2 | 2021-09-20 | ClinicalTrials.gov |
| NCT02699749 | SIMUROSERTIB | PHASE1 | 2021-02-21 | ClinicalTrials.gov |
| NCT00838890 | BMS-863233 | PHASE1/PHASE2 | ClinicalTrials.gov |
NIH grants1,079
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CDC7 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 19 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 10 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 5 | 2025 |
| R01EY022305 | NEIGHBORHOOD Consortium for POAG Genetics | 5 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 4 | 2025 |
| P30EY014104 | P30 Core Grant for Vision Research | 4 | 2025 |
| R01EY013178 | Novel Glaucoma Diagnostics for Structure and Function. | 4 | 2025 |
| ZIABC010411 | Initiation of DNA Replication in Mammalian Cells | 4 | 2025 |
1 to 10 of 1,079Source NIH's project files
See all 1,079 nih grantsPapers1,550
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Gene polymorphisms associated with progression of primary open-angle glaucoma: A systematic review. | Surv Ophthalmol | 2026 | 42754173 | PubTator, text mining | PubMed |
| Correction: Pauzaite et al. Dbf4-Cdc7 (DDK) Inhibitor PHA-767491 Displays Potent Anti-Proliferative Effects via Crosstalk with the CDK2-RB-E2F Pathway. Biomedicines 2022, 10, 2012. | Biomedicines | 2026 | 42652259 | PubTator, text mining | PubMed |
| CDC7 and APC/CCdh1 gate distinct routes to initiate DNA replication. | Nat Commun | 2026 | 42642404 | PubTator, text mining | PubMed |
| NCES: A Cell-Specific Network-Augmented Essentiality Framework for Cancer Therapeutic Target Discovery. | Comput Struct Biotechnol J | 2026 | 42491358 | PubTator, text mining | PubMed |
| Antitumor effects of the novel docetaxel derivative JJH201601 in glioma: targeting ribosome biogenesis and enhancing temozolomide sensitivity. | J Transl Med | 2026 | 42436511 | PubTator, text mining | PubMed |
| Design, Optimization and Mechanistic Insights Into Terpenoid-Derived Inhibitors of Protein Kinase C Iota. | Chem Biol Drug Des | 2026 | 42359997 | PubTator, text mining | PubMed |
| Exploring the multifaceted Dbf4-dependent kinase from temporal, spatial, and substrate repertoire perspectives. | Commun Biol | 2026 | 42337302 | PubTator, text mining | PubMed |
| Replication origin firing capacity indicates ATR inhibitor sensitivity. | Nat Commun | 2026 | 42321192 | PubTator, text mining | PubMed |
| EBNA1 inhibitors reveal CDC7 and POU2F1 as direct functional targets in EBV epithelial cancers. | mBio | 2026 | 42132380 | PubTator, text mining | PubMed |
| Predicting DNA replication-related protein expression at the nucleus level from HE: A deep learning study with same-specimen paired data. | Acta Histochem | 2026 | 42035593 | PubTator, text mining | PubMed |
1 to 10 of 1,550
See all 1,550 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8317
GET https://conductscience.org/api/genes/v1/8317/patents?page=2