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Gene · 8317

CDC7: cell division cycle 7

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CDC7: cell division cycle 7. Genes, record 8317. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8317

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Gene

Symbol
CDC7
HGNC
Name
cell division cycle 7
HGNC
NCBI Gene ID
8317
NCBI Gene
HGNC ID
HGNC:1745
HGNC
Ensembl
ENSG00000097046
NCBI Gene
Aliases
CDC7L1, HsCDC7, HsCdc7, Hsk1, huCDC7, huCdc7
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00311Cell division cycle 7-related protein kinase5749Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1440787O00311Espacenet
JP 2026004568 A2026-01-1440790O00311Espacenet
EP 4650780 A22025-11-19892O00311Espacenet
EP 4641201 A22025-10-29629O00311Espacenet
JP 2025517969 A2025-06-12629O00311Espacenet
JP 2025517970 A2025-06-12892O00311Espacenet
US 11976334 B22024-05-07129O00311Espacenet
US 11860162 B22024-01-021545O00311Espacenet
US 11446398 B22022-09-2013759O00311Espacenet
US 11446398 B22022-09-2013760O00311Espacenet

1 to 10 of 57

See all 57 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BMS-863233CHEMBL3544944Cell division cycle 7-related protein kinase inhibitorINHIBITORChEMBL
NMS-1116354CHEMBL3545321Cell division cycle 7-related protein kinase inhibitorINHIBITORChEMBL
RXDX-103CHEMBL3545090Cell division cycle 7-related protein kinase inhibitorINHIBITORChEMBL
SIMUROSERTIBCHEMBL4297644Cell division cycle 7-related protein kinase inhibitorINHIBITORChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03261947SIMUROSERTIBPHASE22021-09-20ClinicalTrials.gov
NCT02699749SIMUROSERTIBPHASE12021-02-21ClinicalTrials.gov
NCT00838890BMS-863233PHASE1/PHASE2ClinicalTrials.gov

NIH grants1,079

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCDC7 papersNewest fiscal year
P30CA008748Cancer Center Support Grant192025
P30ES010126UNC Center for Environmental Health and Susceptibility102025
P30CA016086Cancer Center Support Grant62025
P30CA016672Cancer Center Support Grant52025
P30CA046934University of Colorado Cancer Center Support Grant52025
R01EY022305NEIGHBORHOOD Consortium for POAG Genetics52025
P30CA047904Cancer Center Support Grant42025
P30EY014104P30 Core Grant for Vision Research42025
R01EY013178Novel Glaucoma Diagnostics for Structure and Function.42025
ZIABC010411Initiation of DNA Replication in Mammalian Cells42025

1 to 10 of 1,079Source NIH's project files

See all 1,079 nih grants

Papers1,550

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Gene polymorphisms associated with progression of primary open-angle glaucoma: A systematic review.Surv Ophthalmol202642754173PubTator, text miningPubMed
Correction: Pauzaite et al. Dbf4-Cdc7 (DDK) Inhibitor PHA-767491 Displays Potent Anti-Proliferative Effects via Crosstalk with the CDK2-RB-E2F Pathway. Biomedicines 2022, 10, 2012.Biomedicines202642652259PubTator, text miningPubMed
CDC7 and APC/CCdh1 gate distinct routes to initiate DNA replication.Nat Commun202642642404PubTator, text miningPubMed
NCES: A Cell-Specific Network-Augmented Essentiality Framework for Cancer Therapeutic Target Discovery.Comput Struct Biotechnol J202642491358PubTator, text miningPubMed
Antitumor effects of the novel docetaxel derivative JJH201601 in glioma: targeting ribosome biogenesis and enhancing temozolomide sensitivity.J Transl Med202642436511PubTator, text miningPubMed
Design, Optimization and Mechanistic Insights Into Terpenoid-Derived Inhibitors of Protein Kinase C Iota.Chem Biol Drug Des202642359997PubTator, text miningPubMed
Exploring the multifaceted Dbf4-dependent kinase from temporal, spatial, and substrate repertoire perspectives.Commun Biol202642337302PubTator, text miningPubMed
Replication origin firing capacity indicates ATR inhibitor sensitivity.Nat Commun202642321192PubTator, text miningPubMed
EBNA1 inhibitors reveal CDC7 and POU2F1 as direct functional targets in EBV epithelial cancers.mBio202642132380PubTator, text miningPubMed
Predicting DNA replication-related protein expression at the nucleus level from HE: A deep learning study with same-specimen paired data.Acta Histochem202642035593PubTator, text miningPubMed

1 to 10 of 1,550

See all 1,550 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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