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Gene · 8318

CDC45: cell division cycle 45

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CDC45: cell division cycle 45. Genes, record 8318. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8318

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Gene

Symbol
CDC45
HGNC
Name
cell division cycle 45
HGNC
NCBI Gene ID
8318
NCBI Gene
HGNC ID
HGNC:1739
HGNC
Ensembl
ENSG00000093009
NCBI Gene
Aliases
CDC45L, CDC45L2, MGORS7, PORC-PI-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75419Cell division control protein 45 homolog5667Ensembl, GeneID, HGNC

Source UniProt

Patents80

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4661917 A12025-12-1711O75419Espacenet
EP 4641202 A22025-10-294557O75419Espacenet
JP 2025147176 A2025-10-062454O75419Espacenet
JP 2025147176 A2025-10-062455O75419Espacenet
JP 2025529142 A2025-09-045798O75419Espacenet
US 12371689 B22025-07-295798O75419Espacenet
JP 2025028160 A2025-02-282454O75419Espacenet
JP 2025028160 A2025-02-282455O75419Espacenet
KR 1020250017231 A2025-02-044557O75419Espacenet
KR 1020250010750 A2025-01-212454O75419Espacenet

1 to 10 of 80

See all 80 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,092

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCDC45 papersNewest fiscal year
P30CA016086Cancer Center Support Grant102025
P30CA008748Cancer Center Support Grant82025
P30CA076292Moffitt Cancer Center Support Grant82025
P30ES010126UNC Center for Environmental Health and Susceptibility82025
ZIABC010411Initiation of DNA Replication in Mammalian Cells82025
R01GM045436Initiation of DNA Replication at Cell Origins in Yeast72025
ZIABC006150DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs72025
P30CA068485Cancer Center Support Grant62025
ZIAAG000741Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability62025
ZIAAG000726Function of RecQ helicases in genome stability52025

1 to 10 of 1,092Source NIH's project files

See all 1,092 nih grants

Papers1,933

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Rhein attenuates neointimal hyperplasia by inhibiting VSMC proliferation via MAPK-mediated downregulation of CDC45.Eur J Pharmacol202642810495PubTator, text miningPubMed
Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation.Nat Commun202642733061PubTator, text miningPubMed
Identification of a novel and a recurrent CDC45 variant in a Chinese family with Meier-Gorlin syndrome 7 and a literature review.Front Genet202642703585PubTator, text miningPubMed
Mechanisms of MCM2-7 helicase activation and initial DNA melting at near base-pair resolution.Nat Commun202642642389PubTator, text miningPubMed
Integrative omics and network pharmacology analysis of Glossocardia bosvallia L. phytocompounds for non-small cell lung carcinoma: Multi-target mechanism and molecular insights.Comput Biol Chem202642585776PubTator, text miningPubMed
CDCA8 regulates ATP5F1A protein stability and malignant phenotypes in wilms tumor cells: Prognostic implications and mechanistic insights.PLoS One202642479720PubTator, text miningPubMed
TTF2 processes sites of incomplete DNA replication during mitosis via sister-chromatid exchanges.Science202642391325PubTator, text miningPubMed
Acidosis-associated gene signature defines novel subtypes and dual-target therapeutic candidates in breast cancer.J Transl Med202642374456PubTator, text miningPubMed
Replication origin firing capacity indicates ATR inhibitor sensitivity.Nat Commun202642321192PubTator, text miningPubMed
Targeting AURKB Attenuates Tumor Growth in MYC-driven Lung Adenocarcinoma.Anticancer Res202642203345PubTator, text miningPubMed

1 to 10 of 1,933

See all 1,933 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8318

GET https://conductscience.org/api/genes/v1/8318/patents?page=2