Gene · 8318
CDC45: cell division cycle 45
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CDC45: cell division cycle 45. Genes, record 8318. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8318
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O75419 | Cell division control protein 45 homolog | 566 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents80
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4661917 A1 | 2025-12-17 | 11 | O75419 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4557 | O75419 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 2454 | O75419 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 2455 | O75419 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 5798 | O75419 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 5798 | O75419 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 2454 | O75419 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 2455 | O75419 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4557 | O75419 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 2454 | O75419 | Espacenet |
1 to 10 of 80
See all 80 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,092
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CDC45 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016086 | Cancer Center Support Grant | 10 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 8 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 8 | 2025 |
| ZIABC010411 | Initiation of DNA Replication in Mammalian Cells | 8 | 2025 |
| R01GM045436 | Initiation of DNA Replication at Cell Origins in Yeast | 7 | 2025 |
| ZIABC006150 | DNA Repair, Cell Cycle Checkpoints and Apoptosis as Targets for Anticancer Drugs | 7 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 6 | 2025 |
| ZIAAG000741 | Roles Of DNA Helicases In Pathways Required For Maintenance Of Genomic Stability | 6 | 2025 |
| ZIAAG000726 | Function of RecQ helicases in genome stability | 5 | 2025 |
1 to 10 of 1,092Source NIH's project files
See all 1,092 nih grantsPapers1,933
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Rhein attenuates neointimal hyperplasia by inhibiting VSMC proliferation via MAPK-mediated downregulation of CDC45. | Eur J Pharmacol | 2026 | 42810495 | PubTator, text mining | PubMed |
| Structural insights into Sld3-Sld7-dependent Cdc45 loading during replication initiation. | Nat Commun | 2026 | 42733061 | PubTator, text mining | PubMed |
| Identification of a novel and a recurrent CDC45 variant in a Chinese family with Meier-Gorlin syndrome 7 and a literature review. | Front Genet | 2026 | 42703585 | PubTator, text mining | PubMed |
| Mechanisms of MCM2-7 helicase activation and initial DNA melting at near base-pair resolution. | Nat Commun | 2026 | 42642389 | PubTator, text mining | PubMed |
| Integrative omics and network pharmacology analysis of Glossocardia bosvallia L. phytocompounds for non-small cell lung carcinoma: Multi-target mechanism and molecular insights. | Comput Biol Chem | 2026 | 42585776 | PubTator, text mining | PubMed |
| CDCA8 regulates ATP5F1A protein stability and malignant phenotypes in wilms tumor cells: Prognostic implications and mechanistic insights. | PLoS One | 2026 | 42479720 | PubTator, text mining | PubMed |
| TTF2 processes sites of incomplete DNA replication during mitosis via sister-chromatid exchanges. | Science | 2026 | 42391325 | PubTator, text mining | PubMed |
| Acidosis-associated gene signature defines novel subtypes and dual-target therapeutic candidates in breast cancer. | J Transl Med | 2026 | 42374456 | PubTator, text mining | PubMed |
| Replication origin firing capacity indicates ATR inhibitor sensitivity. | Nat Commun | 2026 | 42321192 | PubTator, text mining | PubMed |
| Targeting AURKB Attenuates Tumor Growth in MYC-driven Lung Adenocarcinoma. | Anticancer Res | 2026 | 42203345 | PubTator, text mining | PubMed |
1 to 10 of 1,933
See all 1,933 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8318
GET https://conductscience.org/api/genes/v1/8318/patents?page=2