Gene · 8321
FZD1: frizzled class receptor 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FZD1: frizzled class receptor 1. Genes, record 8321. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8321
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UP38 | Frizzled-1 | 647 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents84
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026219982 A1 | 2026-10-22 | 9 | Q9UP38 | Espacenet |
| WO 2026219984 A1 | 2026-10-22 | 9 | Q9UP38 | Espacenet |
| WO 2026219985 A1 | 2026-10-22 | 9 | Q9UP38 | Espacenet |
| WO 2026219987 A1 | 2026-10-22 | 9 | Q9UP38 | Espacenet |
| WO 2026219989 A1 | 2026-10-22 | 9 | Q9UP38 | Espacenet |
| WO 2026220051 A1 | 2026-10-22 | 9 | Q9UP38 | Espacenet |
| WO 2026183201 A1 | 2026-09-03 | 1 | Q9UP38 | Espacenet |
| WO 2026183314 A1 | 2026-09-03 | 1 | Q9UP38 | Espacenet |
| JP 2026120541 A | 2026-07-22 | 57 | Q9UP38 | Espacenet |
| JP 2026082857 A | 2026-05-19 | 57 | Q9UP38 | Espacenet |
1 to 10 of 84
See all 84 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| VANTICTUMAB | CHEMBL2364652 | Frizzled-1 antagonist | ANTAGONIST |
Source ChEMBL
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02005315 | VANTICTUMAB | PHASE1 | ClinicalTrials.gov | |
| NCT01973309 | VANTICTUMAB | PHASE1 | ClinicalTrials.gov | |
| NCT01957007 | VANTICTUMAB | PHASE1 | ClinicalTrials.gov |
NIH grants1,683
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FZD1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 12 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 5 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 4 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 4 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 4 | 2025 |
| R01EY021797 | Development of Stem Cell-based Therapies for Limbal Stem Cell Deficiency | 4 | 2025 |
| T32AG000181 | Training in the Epidemiology of Aging | 4 | 2025 |
| ZIABC010891 | Development of antibody engineering-based cancer therapies | 4 | 2025 |
1 to 10 of 1,683Source NIH's project files
See all 1,683 nih grantsPapers2,162
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| RNF research trends and an RNF43-based prognostic model for colorectal cancer with immune microenvironment analysis. | Discov Oncol | 2026 | 42671492 | PubTator, text mining | PubMed |
| Heparan Sulfate Controls Nanoscale Assembly of GPC3-Wnt Receptor Complexes. | bioRxiv | 2026 | 42538985 | PubTator, text mining | PubMed |
| Single-cell and longitudinal transcriptomics-guided engineering of FZD1-targeting precision nanotherapy against osteosarcoma cancer stem cells. | Bioact Mater | 2026 | 42472087 | PubTator, text mining | PubMed |
| CSF proteome-wide study of neuropsychiatric symptoms of dementia. | medRxiv | 2026 | 42428132 | PubTator, text mining | PubMed |
| Autoencoder Denoising for Network-Based Spatial Transcriptomics Data with Applications for Cell Signaling Estimation. | Complex Netw Appl | 2026 | 42181748 | PubTator, text mining | PubMed |
| JOSD1 stabilizes SULF1 to activate Wnt7B-FZD1 signaling in gastric cancer. | Transl Oncol | 2026 | 42140034 | PubTator, text mining | PubMed |
| Midazolam and Dexmedetomidine Promoted Migration of Human Lung Adenocarcinoma A549 Cells. | J Nippon Med Sch | 2026 | 42091510 | PubTator, text mining | PubMed |
| Overexpression of IGF2 Alters the Transcriptional Profile of Goose Skeletal Muscle Satellite Cells. | Biomolecules | 2026 | 42072686 | PubTator, text mining | PubMed |
| Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation. | J Biomed Mater Res B Appl Biomater | 2026 | 42032797 | PubTator, text mining | PubMed |
| Hsa-miR-99a deficiency contributes to MSI-H colorectal cancer progression by activating the mTOR pathway and inducing Th1/Th2 imbalance. | Front Immunol | 2026 | 41924263 | PubTator, text mining | PubMed |
1 to 10 of 2,162
See all 2,162 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8321
GET https://conductscience.org/api/genes/v1/8321/patents?page=2