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Gene · 8321

FZD1: frizzled class receptor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FZD1: frizzled class receptor 1. Genes, record 8321. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8321

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Gene

Symbol
FZD1
HGNC
Name
frizzled class receptor 1
HGNC
NCBI Gene ID
8321
NCBI Gene
HGNC ID
HGNC:4038
HGNC
Ensembl
ENSG00000157240
NCBI Gene
Aliases
DKFZp564G072, Hfz1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UP38Frizzled-16472Ensembl, GeneID, HGNC

Source UniProt

Patents84

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026219982 A12026-10-229Q9UP38Espacenet
WO 2026219984 A12026-10-229Q9UP38Espacenet
WO 2026219985 A12026-10-229Q9UP38Espacenet
WO 2026219987 A12026-10-229Q9UP38Espacenet
WO 2026219989 A12026-10-229Q9UP38Espacenet
WO 2026220051 A12026-10-229Q9UP38Espacenet
WO 2026183201 A12026-09-031Q9UP38Espacenet
WO 2026183314 A12026-09-031Q9UP38Espacenet
JP 2026120541 A2026-07-2257Q9UP38Espacenet
JP 2026082857 A2026-05-1957Q9UP38Espacenet

1 to 10 of 84

See all 84 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
VANTICTUMABCHEMBL2364652Frizzled-1 antagonistANTAGONIST

Source ChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02005315VANTICTUMABPHASE1ClinicalTrials.gov
NCT01973309VANTICTUMABPHASE1ClinicalTrials.gov
NCT01957007VANTICTUMABPHASE1ClinicalTrials.gov

NIH grants1,683

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFZD1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant122025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
P30CA008748Cancer Center Support Grant52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant42025
P30CA046934University of Colorado Cancer Center Support Grant42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
R01EY021797Development of Stem Cell-based Therapies for Limbal Stem Cell Deficiency42025
T32AG000181Training in the Epidemiology of Aging42025
ZIABC010891Development of antibody engineering-based cancer therapies42025

1 to 10 of 1,683Source NIH's project files

See all 1,683 nih grants

Papers2,162

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
RNF research trends and an RNF43-based prognostic model for colorectal cancer with immune microenvironment analysis.Discov Oncol202642671492PubTator, text miningPubMed
Heparan Sulfate Controls Nanoscale Assembly of GPC3-Wnt Receptor Complexes.bioRxiv202642538985PubTator, text miningPubMed
Single-cell and longitudinal transcriptomics-guided engineering of FZD1-targeting precision nanotherapy against osteosarcoma cancer stem cells.Bioact Mater202642472087PubTator, text miningPubMed
CSF proteome-wide study of neuropsychiatric symptoms of dementia.medRxiv202642428132PubTator, text miningPubMed
Autoencoder Denoising for Network-Based Spatial Transcriptomics Data with Applications for Cell Signaling Estimation.Complex Netw Appl202642181748PubTator, text miningPubMed
JOSD1 stabilizes SULF1 to activate Wnt7B-FZD1 signaling in gastric cancer.Transl Oncol202642140034PubTator, text miningPubMed
Midazolam and Dexmedetomidine Promoted Migration of Human Lung Adenocarcinoma A549 Cells.J Nippon Med Sch202642091510PubTator, text miningPubMed
Overexpression of IGF2 Alters the Transcriptional Profile of Goose Skeletal Muscle Satellite Cells.Biomolecules202642072686PubTator, text miningPubMed
Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.J Biomed Mater Res B Appl Biomater202642032797PubTator, text miningPubMed
Hsa-miR-99a deficiency contributes to MSI-H colorectal cancer progression by activating the mTOR pathway and inducing Th1/Th2 imbalance.Front Immunol202641924263PubTator, text miningPubMed

1 to 10 of 2,162

See all 2,162 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8321

GET https://conductscience.org/api/genes/v1/8321/patents?page=2