Gene · 8322
FZD4: frizzled class receptor 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. FZD4: frizzled class receptor 4. Genes, record 8322. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8322
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9ULV1 | Frizzled-4 | 537 | 11 | Ensembl, GeneID, HGNC |
Source UniProt
Patents56
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026183201 A1 | 2026-09-03 | 4 | Q9ULV1 | Espacenet |
| WO 2026183314 A1 | 2026-09-03 | 4 | Q9ULV1 | Espacenet |
| JP 2026120541 A | 2026-07-22 | 63 | Q9ULV1 | Espacenet |
| JP 2026082857 A | 2026-05-19 | 63 | Q9ULV1 | Espacenet |
| JP 2026515744 A | 2026-05-19 | 204 | Q9ULV1 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 46709 | Q9ULV1 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 15657 | Q9ULV1 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1641 | Q9ULV1 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1641 | Q9ULV1 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 15657 | Q9ULV1 | Espacenet |
1 to 10 of 56
See all 56 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,421
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | FZD4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| R01NS100904 | Mechanistic and Therapeutic Studies of GPR124/RECK/WNT7-Regulated Blood-Brain Barrier Function | 5 | 2025 |
| P30EY014801 | Miami Center for Vision Research | 4 | 2025 |
| R01EY015130 | Mechanisms of Angiogenesis in ROP | 4 | 2025 |
| R01EY017011 | Endothelial Transmigration in Neovascular Age-related Macular Degeneration | 4 | 2025 |
| R01EY021797 | Development of Stem Cell-based Therapies for Limbal Stem Cell Deficiency | 4 | 2025 |
| R35GM118082 | Signal transduction in development and disease | 4 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 3 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 3 | 2025 |
| P30CA054174 | Mays Cancer Center at UT Health SA | 3 | 2025 |
1 to 10 of 1,421Source NIH's project files
See all 1,421 nih grantsPapers2,273
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Clinical and Multimodal Imaging Features of Familial Exudative Vitreoretinopathy: The Genetic and Phenotypic Spectrum. | Clin Ophthalmol | 2026 | 42751639 | PubTator, text mining | PubMed |
| miR-424-5p Regulates Stem-like and Malignant Phenotypes in Osteosarcoma by Targeting FZD4. | Cancers (Basel) | 2026 | 42738367 | PubTator, text mining | PubMed |
| Progression in familial exudative vitreoretinopathy: Long-term clinical course and baseline predictors. | Graefes Arch Clin Exp Ophthalmol | 2026 | 42635748 | PubTator, text mining | PubMed |
| Loss of YY1 in Purkinje cells triggers cerebellar ataxia via Wnt10b-mediated impairment of dendrite development. | iScience | 2026 | 42572605 | PubTator, text mining | PubMed |
| Prenatal Etiology Diagnosis of Rare Compound Heterozygous PROC Gene Variants in a Fetus With Ocular Ultrasonic Anomaly Using Whole Exome Sequencing. | Mol Genet Genomic Med | 2026 | 42487276 | PubTator, text mining | PubMed |
| Tetraspanins bring Norrin into focus: Structural insights into ligand-specific Wnt signaling. | Structure | 2026 | 42392031 | PubTator, text mining | PubMed |
| Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modelling. | Nat Biomed Eng | 2026 | 42380331 | PubTator, text mining | PubMed |
| The calcium pump ATP2B1/PMCA1 regulates CNS vascular development by facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling. | Cell Rep | 2026 | 42348420 | PubTator, text mining | PubMed |
| Structural basis of the interaction between Norrin-Tspan12. | Structure | 2026 | 42155446 | PubTator, text mining | PubMed |
| Tenosynovial Giant Cell Tumor (TGCT) in the Hip Joint With an APOB Mutation. | Case Rep Orthop | 2026 | 42148342 | PubTator, text mining | PubMed |
1 to 10 of 2,273
See all 2,273 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8322
GET https://conductscience.org/api/genes/v1/8322/patents?page=2