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Gene · 8322

FZD4: frizzled class receptor 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FZD4: frizzled class receptor 4. Genes, record 8322. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8322

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Gene

Symbol
FZD4
HGNC
Name
frizzled class receptor 4
HGNC
NCBI Gene ID
8322
NCBI Gene
HGNC ID
HGNC:4042
HGNC
Ensembl
ENSG00000174804
NCBI Gene
Aliases
CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9ULV1Frizzled-453711Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026183201 A12026-09-034Q9ULV1Espacenet
WO 2026183314 A12026-09-034Q9ULV1Espacenet
JP 2026120541 A2026-07-2263Q9ULV1Espacenet
JP 2026082857 A2026-05-1963Q9ULV1Espacenet
JP 2026515744 A2026-05-19204Q9ULV1Espacenet
JP 2026004568 A2026-01-1446709Q9ULV1Espacenet
EP 4650780 A22025-11-1915657Q9ULV1Espacenet
JP 2025529142 A2025-09-041641Q9ULV1Espacenet
US 12371689 B22025-07-291641Q9ULV1Espacenet
JP 2025517970 A2025-06-1215657Q9ULV1Espacenet

1 to 10 of 56

See all 56 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,421

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFZD4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant52025
R01NS100904Mechanistic and Therapeutic Studies of GPR124/RECK/WNT7-Regulated Blood-Brain Barrier Function52025
P30EY014801Miami Center for Vision Research42025
R01EY015130Mechanisms of Angiogenesis in ROP42025
R01EY017011Endothelial Transmigration in Neovascular Age-related Macular Degeneration42025
R01EY021797Development of Stem Cell-based Therapies for Limbal Stem Cell Deficiency42025
R35GM118082Signal transduction in development and disease42025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025
P30CA006973Regional Oncology Research Center32025
P30CA054174Mays Cancer Center at UT Health SA32025

1 to 10 of 1,421Source NIH's project files

See all 1,421 nih grants

Papers2,273

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical and Multimodal Imaging Features of Familial Exudative Vitreoretinopathy: The Genetic and Phenotypic Spectrum.Clin Ophthalmol202642751639PubTator, text miningPubMed
miR-424-5p Regulates Stem-like and Malignant Phenotypes in Osteosarcoma by Targeting FZD4.Cancers (Basel)202642738367PubTator, text miningPubMed
Progression in familial exudative vitreoretinopathy: Long-term clinical course and baseline predictors.Graefes Arch Clin Exp Ophthalmol202642635748PubTator, text miningPubMed
Loss of YY1 in Purkinje cells triggers cerebellar ataxia via Wnt10b-mediated impairment of dendrite development.iScience202642572605PubTator, text miningPubMed
Prenatal Etiology Diagnosis of Rare Compound Heterozygous PROC Gene Variants in a Fetus With Ocular Ultrasonic Anomaly Using Whole Exome Sequencing.Mol Genet Genomic Med202642487276PubTator, text miningPubMed
Tetraspanins bring Norrin into focus: Structural insights into ligand-specific Wnt signaling.Structure202642392031PubTator, text miningPubMed
Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modelling.Nat Biomed Eng202642380331PubTator, text miningPubMed
The calcium pump ATP2B1/PMCA1 regulates CNS vascular development by facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling.Cell Rep202642348420PubTator, text miningPubMed
Structural basis of the interaction between Norrin-Tspan12.Structure202642155446PubTator, text miningPubMed
Tenosynovial Giant Cell Tumor (TGCT) in the Hip Joint With an APOB Mutation.Case Rep Orthop202642148342PubTator, text miningPubMed

1 to 10 of 2,273

See all 2,273 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8322

GET https://conductscience.org/api/genes/v1/8322/patents?page=2