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Gene · 8324

FZD7: frizzled class receptor 7

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FZD7: frizzled class receptor 7. Genes, record 8324. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8324

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Gene

Symbol
FZD7
HGNC
Name
frizzled class receptor 7
HGNC
NCBI Gene ID
8324
NCBI Gene
HGNC ID
HGNC:4045
HGNC
Ensembl
ENSG00000155760
NCBI Gene
Aliases
FzE3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75084Frizzled-757413Ensembl, GeneID, HGNC

Source UniProt

Patents97

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026183201 A12026-09-037O75084Espacenet
WO 2026183314 A12026-09-037O75084Espacenet
JP 2026120541 A2026-07-2269O75084Espacenet
JP 2026082857 A2026-05-1969O75084Espacenet
EP 4650780 A22025-11-193280O75084Espacenet
JP 2025529142 A2025-09-041644O75084Espacenet
US 12371689 B22025-07-291644O75084Espacenet
JP 2025517970 A2025-06-123280O75084Espacenet
JP 2025032204 A2025-03-1128653O75084Espacenet
EP 4461818 A22024-11-1328653O75084Espacenet

1 to 10 of 97

See all 97 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
VANTICTUMABCHEMBL2364652Frizzled-7 antagonistANTAGONIST

Source ChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02005315VANTICTUMABPHASE1ClinicalTrials.gov
NCT01973309VANTICTUMABPHASE1ClinicalTrials.gov
NCT01957007VANTICTUMABPHASE1ClinicalTrials.gov

NIH grants1,196

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFZD7 papersNewest fiscal year
R01EY021797Development of Stem Cell-based Therapies for Limbal Stem Cell Deficiency92025
R01AR044031Genetic Regulation of Skeletal Muscle Repair82025
P30EY000331Vision Research Core at UCLA62025
P30CA016672Cancer Center Support Grant52025
T32CA067754Cancer Biology, Informatics & Omics (CBIO) Training Program52025
P20GM103446Delaware INBRE42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
P30CA062203Cancer Center Support Grant42025
P30EY001792P30 Core Grant for Vision Research42025
R01EY013431Mechanisms of epithelial alterations in diabetic cornea42025

1 to 10 of 1,196Source NIH's project files

See all 1,196 nih grants

Papers1,967

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Midazolam Reduces Metabolic Viability and Induces Apoptosis in MIA PaCa-2 Pancreatic Cancer Cells with Selective Transcriptional Modulation of Wnt and Hedgehog Components: A Preliminary In Vitro Study.
Pharmaceuticals (Basel)202642797517PubTator, text miningPubMed
Non-canonical Wnt11/PCP/YAP signaling mediates epithelial-mesenchymal transition and immunosuppressive tumor microenvironment in colorectal cancer.Int Immunopharmacol202642760160PubTator, text miningPubMed
Genomic diversification between aposematic and cryptic phenotypes of Oophaga granulifera (Anura: Dendrobatidae).Sci Rep202642661044PubTator, text miningPubMed
FZD7 drives retinal ferroptosis in diabetic retinopathy via β-catenin-dependent suppression of the DHODH/FSP1 axis.J Pharmacol Sci202642632747PubTator, text miningPubMed
FZD7 Inhibitor SRI Attenuates High Glucose-Induced Retinal Pigment Epithelial Cell Injury Accompanied by Ferroptosis-Associated Changes via Suppression of the Wnt/β-Catenin Pathway.Endocrinol Diabetes Metab202642487268PubTator, text miningPubMed
NKD1 promotes the progression and 5-FU resistance of colorectal cancer via the Wnt/β-catenin signaling.Cell Death Dis202642431857PubTator, text miningPubMed
Analysis of Formimidoyltransferase Cyclodeaminase as a Potential Prognostic Biomarker and Therapeutic Target in Colorectal Cancer.Cancer Genomics Proteomics202642373224PubTator, text miningPubMed
Transcriptomic analysis identifies novel ferroptosis-related biomarkers and therapeutic targets in pulmonary arterial hypertension.J Hypertens202642267557PubTator, text miningPubMed
CircSPARC promotes esophageal squamous cell carcinoma through an HNRNPC-EPN2 splicing axis that activates Wnt/β-Catenin signaling.Mol Cancer202642210380PubTator, text miningPubMed
Enhancing the Antitumor Efficacy of Nisin Through Advanced Nanosystems: A Systematic Review of In Vitro Studies.Pharmaceuticals (Basel)202642075866PubTator, text miningPubMed

1 to 10 of 1,967

See all 1,967 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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