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CASP1: caspase 1

1 protein, 146 patents, 3 drugs, 18 trials, 9,638 NIH grants and 28,217 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCASP1HGNC
Namecaspase 1HGNC
NCBI Gene ID834NCBI Gene
HGNC IDHGNC:1499HGNC
EnsemblENSG00000137752NCBI Gene
AliasesICE, IL1BC, P45NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29466Caspase-140442Ensembl, GeneID, HGNCUniProt

Patents 146

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4705273 A22026-03-11563P29466Espacenet
US 12539325 B22026-02-0318P29466Espacenet
EP 4667578 A22025-12-24250P29466Espacenet
EP 4641201 A22025-10-2915625P29466Espacenet
JP 2025131621 A2025-09-09250P29466Espacenet
JP 2025517969 A2025-06-1215625P29466Espacenet
JP 2025062604 A2025-04-1412219P29466Espacenet
JP 2025062604 A2025-04-1412222P29466Espacenet
JP 2025013347 A2025-01-24563P29466Espacenet
US 12133879 B22024-11-0518P29466Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BELNACASANCHEMBL2107819Caspase-1 inhibitorINHIBITORChEMBL
EMRICASANCHEMBL197672Caspase inhibitorINHIBITORChEMBL
NIVOCASANCHEMBL2105721Caspase-1 inhibitorINHIBITORChEMBL

Trials 18

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05164120BELNACASANPHASE22024-09-19ClinicalTrials.gov
NCT04803227EMRICASANPHASE1ClinicalTrials.gov
NCT03205345EMRICASANPHASE2ClinicalTrials.gov
NCT02686762EMRICASANPHASE2ClinicalTrials.gov
NCT02230683EMRICASANPHASE22016-12-21ClinicalTrials.gov
NCT02230670EMRICASANPHASE22017-07-05ClinicalTrials.gov
NCT02138253EMRICASANPHASE22019-12-11ClinicalTrials.gov
NCT02077374EMRICASANPHASE22016-07-21ClinicalTrials.gov
NCT01937130EMRICASANPHASE22016-04-11ClinicalTrials.gov
NCT01912404EMRICASANPHASE22016-11-04ClinicalTrials.gov

NIH grants 9638

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01AI015614Pathogenesis of Fever in Man722,025NIH's project files
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation712,025NIH's project files
R01AI124346Innate immune signaling and stress response682,025NIH's project files
P30CA008748Cancer Center Support Grant352,025NIH's project files
R35CA253095Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer332,025NIH's project files
R01AI124491NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing322,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award312,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)302,025NIH's project files
P30CA016672Cancer Center Support Grant282,025NIH's project files
R37AI063331Cryopyrin/NLRP3 Signaling in Inflammation and Innate Immunity262,025NIH's project files

Papers 28217

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820025PubTator, text miningPubMed
42819011PubTator, text miningPubMed
42815265PubTator, text miningPubMed
42815193PubTator, text miningPubMed
42812611PubTator, text miningPubMed
42807632PubTator, text miningPubMed
42807349PubTator, text miningPubMed
42806587PubTator, text miningPubMed
42806415PubTator, text miningPubMed
42806287PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license