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Gene · 83464

APH1B: aph-1B gamma-secretase subunit

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. APH1B: aph-1B gamma-secretase subunit. Genes, record 83464. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/83464

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Gene

Symbol
APH1B
HGNC
Name
aph-1B gamma-secretase subunit
HGNC
NCBI Gene ID
83464
NCBI Gene
HGNC ID
HGNC:24080
HGNC
Ensembl
ENSG00000138613
NCBI Gene
Aliases
APH-1B, DKFZp564D0372, PRO1328, PSFL, TAAV688, aph-1beta
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8WW43Gamma-secretase subunit APH-1B2572Ensembl, GeneID, HGNC

Source UniProt

Patents50

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437619Q8WW43Espacenet
EP 4650780 A22025-11-191978Q8WW43Espacenet
EP 4640849 A22025-10-29238Q8WW43Espacenet
EP 4641201 A22025-10-291552Q8WW43Espacenet
JP 2025529142 A2025-09-04410Q8WW43Espacenet
US 12371689 B22025-07-29410Q8WW43Espacenet
JP 2025519096 A2025-06-24238Q8WW43Espacenet
JP 2025517969 A2025-06-121552Q8WW43Espacenet
JP 2025517970 A2025-06-121978Q8WW43Espacenet
JP 2025062604 A2025-04-145631Q8WW43Espacenet

1 to 10 of 50

See all 50 patents

Drugs7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AVAGACESTATCHEMBL1090771Gamma-secretase inhibitorINHIBITORChEMBL
BEGACESTATCHEMBL463981Gamma-secretase inhibitorINHIBITORChEMBL
NIROGACESTATCHEMBL1770916Gamma-secretase inhibitorINHIBITORChEMBL
NIROGACESTAT HYDROBROMIDECHEMBL4298153Gamma-secretase inhibitorINHIBITORChEMBL
RG-4733CHEMBL4297422Gamma-secretase inhibitorINHIBITORChEMBL
SEMAGACESTATCHEMBL520733Gamma-secretase inhibitorINHIBITORChEMBL
TARENFLURBILCHEMBL190083Gamma-secretase modulatorMODULATORChEMBL

Trials67

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07539454NIROGACESTATPHASE2ClinicalTrials.gov
NCT07176689NIROGACESTATPHASE4ClinicalTrials.gov
NCT07170644NIROGACESTATPHASE2ClinicalTrials.gov
NCT07150104NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT07150091NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT07084896NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT05949099NIROGACESTATPHASE2ClinicalTrials.gov
NCT05879146NIROGACESTATPHASE2ClinicalTrials.gov
NCT05573802NIROGACESTATPHASE1/PHASE2ClinicalTrials.gov
NCT05556798NIROGACESTATPHASE1ClinicalTrials.gov

1 to 10 of 67

See all 67 trials

NIH grants402

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleAPH1B papersNewest fiscal year
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)82025
P30AG066468Alzheimer Disease Research Center22025
P30CA008748Cancer Center Support Grant22025
P30CA016672Cancer Center Support Grant22025
R01AG050986Higher Order Chromatin and Genetic Risk for Alzheimer's Disease22025
U24AG072122National Alzheimer's Coordinating Center22025
ZIAAG000311ALZHEIMERS RESEARCH PROJECT: Design And Development Of Experimental Therapeutics ((Systemic & Neurodegenerative Disorders and Alzheimer's Disease)22025
I01BX004189Large-scale transcriptome and epigenome association analysis across multiple traits12025
K01AA030083Mass Multivariate Derivation and Validation of AUD Biotypes using Developmental Imaging and Genomic Approaches12025
OT2CA278635eDyNAmiC - UCSD12025

1 to 10 of 402Source NIH's project files

See all 402 nih grants

Papers390

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Molecular and genetic basis of alzheimer's disease and emerging treatment Modalities.Neurodegener Dis Manag202642825454PubTator, text miningPubMed
Genetically prioritized druggable targets for amyloid-β pathology highlight ACE as a therapeutic candidate in Alzheimer's disease.J Alzheimers Dis202642212431PubTator, text miningPubMed
Integrative analysis of lysosome-dependent cell death related molecular subtypes and prognosis prediction in papillary thyroid carcinoma.J Cancer202641869448PubTator, text miningPubMed
Distinct Regulatory Genomic Architectures Distinguish Early-Onset from Late-Onset Alzheimer's Disease.Genes (Basel)202641751570PubTator, text miningPubMed
Human papillomavirus16 E7 enhances cell stemness by regulating the APC2/SPIN4/β-catenin axis in cervical cancer.Oncogenesis202641730837PubTator, text miningPubMed
In Silico Phosphoproteomic Analysis Reveals Divergent Regulation of Presenilin 1 and Presenilin 2.Neuromolecular Med202641615513PubTator, text miningPubMed
Mitochondria dysfunction and increased expression of WNT5A and BNIP3 in tenocytes obtained from patients with tendinopathy.JSES Int202641550705PubTator, text miningPubMed
Radiotherapy induces YTHDF2 in dendritic cells impairing cross-presentation and T cell function.J Exp Med202641196643PubTator, text miningPubMed
Prioritizing missense mutations via a deep learning phosphorylation prediction model.Hum Genomics202541469746PubTator, text miningPubMed
Integration of multi-omics quantitative trait loci evidence reveals novel susceptibility genes for Alzheimer's disease.Sci Rep202540820167PubTator, text miningPubMed

1 to 10 of 390

See all 390 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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